Q91XL9 · OSBL1_MOUSE
- ProteinOxysterol-binding protein-related protein 1
- GeneOsbpl1a
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids950 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | late endosome | |
Cellular Component | organelle membrane contact site | |
Molecular Function | lipid binding | |
Biological Process | lipid transport |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOxysterol-binding protein-related protein 1
- Short namesORP-1; OSBP-related protein 1
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ91XL9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000100368 | 1-950 | Oxysterol-binding protein-related protein 1 | ||
Modified residue | 499 | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Interacts (via FFAT motif) with VAPA and VAPB (By similarity).
Interacts with the GTP-bound form of RAB7A (By similarity).
Interacts with OAS1B (PubMed:22623793).
Interacts (via FFAT motif) with MOSPD2 (via MSP domain) (By similarity).
Interacts with the GTP-bound form of RAB7A (By similarity).
Interacts with OAS1B (PubMed:22623793).
Interacts (via FFAT motif) with MOSPD2 (via MSP domain) (By similarity).
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, repeat, domain, coiled coil, motif, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-237 | Interaction with RAB7A | |||
Repeat | 47-76 | ANK 1 | |||
Repeat | 80-109 | ANK 2 | |||
Repeat | 175-204 | ANK 3 | |||
Domain | 235-334 | PH | |||
Coiled coil | 430-463 | ||||
Motif | 469-483 | FFAT | |||
Region | 502-530 | Disordered | |||
Compositional bias | 505-519 | Basic and acidic residues | |||
Compositional bias | 795-809 | Basic and acidic residues | |||
Region | 795-821 | Disordered | |||
Coiled coil | 879-913 | ||||
Domain
The FFAT motif is required for interaction with MOSPD2.
The FFAT motif is required for interaction with MOSPD2, VAPA and VAPB.
Sequence similarities
Belongs to the OSBP family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q91XL9-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsOsbpl1b
- Length950
- Mass (Da)107,795
- Last updated2006-03-21 v2
- ChecksumAA4F5678999B0EB5
Q91XL9-2
- Name2
- SynonymsOsbpl1a
- Differences from canonical
- 1-513: Missing
Q91XL9-3
- Name3
- Differences from canonical
- 1-540: Missing
Computationally mapped potential isoform sequences
There are 11 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q8K2D2 | Q8K2D2_MOUSE | Osbpl1a | 338 | ||
A0A3Q4L372 | A0A3Q4L372_MOUSE | Osbpl1a | 37 | ||
A0A3Q4L2S6 | A0A3Q4L2S6_MOUSE | Osbpl1a | 200 | ||
A0A3Q4EG54 | A0A3Q4EG54_MOUSE | Osbpl1a | 528 | ||
A0A3Q4EG41 | A0A3Q4EG41_MOUSE | Osbpl1a | 51 | ||
D3YZ66 | D3YZ66_MOUSE | Osbpl1a | 187 | ||
D3Z754 | D3Z754_MOUSE | Osbpl1a | 281 | ||
Q3V156 | Q3V156_MOUSE | Osbpl1a | 558 | ||
D3Z7I9 | D3Z7I9_MOUSE | Osbpl1a | 184 | ||
D6RDE4 | D6RDE4_MOUSE | Osbpl1a | 66 | ||
A0A3Q4EI24 | A0A3Q4EI24_MOUSE | Osbpl1a | 547 |
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_017724 | 1-513 | in isoform 2 | ||
Alternative sequence | VSP_017723 | 1-540 | in isoform 3 | ||
Compositional bias | 505-519 | Basic and acidic residues | |||
Sequence conflict | 572 | in Ref. 5; AAH76637 | |||
Sequence conflict | 599 | in Ref. 3; BAA33012 | |||
Sequence conflict | 685 | in Ref. 1; AAK71661 | |||
Sequence conflict | 697-698 | in Ref. 1; AAK71661 | |||
Sequence conflict | 713 | in Ref. 1; AAK71661 | |||
Sequence conflict | 732 | in Ref. 1; AAK71661 | |||
Sequence conflict | 744 | in Ref. 1; AAK71661 | |||
Sequence conflict | 759 | in Ref. 1; AAK71661 | |||
Compositional bias | 795-809 | Basic and acidic residues | |||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF394063 EMBL· GenBank· DDBJ | AAK71661.2 EMBL· GenBank· DDBJ | mRNA | ||
AY536214 EMBL· GenBank· DDBJ | AAT06024.1 EMBL· GenBank· DDBJ | mRNA | ||
AB017026 EMBL· GenBank· DDBJ | BAA33012.1 EMBL· GenBank· DDBJ | mRNA | ||
AK168366 EMBL· GenBank· DDBJ | BAE40301.1 EMBL· GenBank· DDBJ | mRNA | ||
BC076637 EMBL· GenBank· DDBJ | AAH76637.1 EMBL· GenBank· DDBJ | mRNA |