Q91XD7 · CREL1_MOUSE

  • Protein
    Protein disulfide isomerase Creld1
  • Gene
    Creld1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Protein disulfide isomerase (By similarity).
Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (PubMed:30407909).

Catalytic activity

  • Catalyzes the rearrangement of -S-S- bonds in proteins.
    EC:5.3.4.1 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentglutamatergic synapse
Cellular Componentmembrane
Cellular Componentsynapse
Molecular Functioncalcium ion binding
Molecular Functionprotein disulfide isomerase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein disulfide isomerase Creld1
  • EC number
  • Alternative names
    • Cysteine-rich with EGF-like domain protein 1

Gene names

    • Name
      Creld1

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q91XD7
  • Secondary accessions
    • Q8BGJ8

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain30-362Extracellular
Transmembrane363-383Helical
Topological domain384Cytoplasmic
Transmembrane385-405Helical
Topological domain406-420Extracellular

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-29
ChainPRO_000004278230-420Protein disulfide isomerase Creld1
Disulfide bond46↔49Redox-active
Disulfide bond155↔169
Disulfide bond163↔181
Disulfide bond183↔192
Glycosylation205N-linked (GlcNAc...) asparagine
Disulfide bond278↔281Redox-active
Disulfide bond309↔321
Disulfide bond314↔330
Disulfide bond332↔343

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in myoblast C2C12 cells (at protein level).

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for motif, domain, repeat.

TypeIDPosition(s)Description
Motif46-49CXXC
Domain153-193EGF-like 1
Repeat208-255FU 1
Repeat268-315FU 2
Motif278-281CXXC
Domain305-342EGF-like 2; calcium-binding

Sequence similarities

Belongs to the CRELD family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    420
  • Mass (Da)
    45,718
  • Last updated
    2001-12-01 v1
  • Checksum
    4066BF2D739D3179
MAPLPPRGLVPSLLWCLSLFLSLPGPVWLQPSPPPHPSPRAEPHPCHTCRALVDNFNKGLERTIRDNFGGGNTAWEEEKLSKYKDSETRLVEVLEGVCSRSDFECHRLLELSEELVENWWFHRQQEAPDLFQWLCSDSLKLCCPSGTFGPSCLPCPGGTERPCGGYGQCEGEGTRGGSGHCDCQAGYGGEACGQCGLGYFEAERNSSHLVCSACFGPCARCTGPEESHCLQCKKGWALHHLKCVDIDECGTEQATCGADQFCVNTEGSYECRDCAKACLGCMGAGPGRCKKCSRGYQQVGSKCLDVDECETVVCPGENEKCENTEGGYRCVCAEGYRQEDGICVKEQVPESAGFFAEMTEDEMVVLQQMFFGVIICALATLAAKGDLVFTAIFIGAVAAMTGYWLSERSDRVLEGFIKGR

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0AA74KSI5A0AA74KSI5_MOUSECreld1240
A0A9L6KDX8A0A9L6KDX8_MOUSECreld1378
A0A9L6KDL3A0A9L6KDL3_MOUSECreld1337

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK050160
EMBL· GenBank· DDBJ
BAC34101.1
EMBL· GenBank· DDBJ
mRNA
AK050455
EMBL· GenBank· DDBJ
BAC34266.1
EMBL· GenBank· DDBJ
mRNA
AK155777
EMBL· GenBank· DDBJ
BAE33433.1
EMBL· GenBank· DDBJ
mRNA
BC010804
EMBL· GenBank· DDBJ
AAH10804.1
EMBL· GenBank· DDBJ
mRNA
BC023893
EMBL· GenBank· DDBJ
AAH23893.1
EMBL· GenBank· DDBJ
mRNA
BC025932
EMBL· GenBank· DDBJ
AAH25932.1
EMBL· GenBank· DDBJ
mRNA
BC029065
EMBL· GenBank· DDBJ
AAH29065.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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