Q91XD7 · CREL1_MOUSE
- ProteinProtein disulfide isomerase Creld1
- GeneCreld1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids420 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Protein disulfide isomerase (By similarity).
Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (PubMed:30407909).
Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (PubMed:30407909).
Catalytic activity
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | glutamatergic synapse | |
Cellular Component | membrane | |
Cellular Component | synapse | |
Molecular Function | calcium ion binding | |
Molecular Function | protein disulfide isomerase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein disulfide isomerase Creld1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ91XD7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 30-362 | Extracellular | ||||
Sequence: QPSPPPHPSPRAEPHPCHTCRALVDNFNKGLERTIRDNFGGGNTAWEEEKLSKYKDSETRLVEVLEGVCSRSDFECHRLLELSEELVENWWFHRQQEAPDLFQWLCSDSLKLCCPSGTFGPSCLPCPGGTERPCGGYGQCEGEGTRGGSGHCDCQAGYGGEACGQCGLGYFEAERNSSHLVCSACFGPCARCTGPEESHCLQCKKGWALHHLKCVDIDECGTEQATCGADQFCVNTEGSYECRDCAKACLGCMGAGPGRCKKCSRGYQQVGSKCLDVDECETVVCPGENEKCENTEGGYRCVCAEGYRQEDGICVKEQVPESAGFFAEMTEDE | ||||||
Transmembrane | 363-383 | Helical | ||||
Sequence: MVVLQQMFFGVIICALATLAA | ||||||
Topological domain | 384 | Cytoplasmic | ||||
Sequence: K | ||||||
Transmembrane | 385-405 | Helical | ||||
Sequence: GDLVFTAIFIGAVAAMTGYWL | ||||||
Topological domain | 406-420 | Extracellular | ||||
Sequence: SERSDRVLEGFIKGR |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-29 | |||||
Sequence: MAPLPPRGLVPSLLWCLSLFLSLPGPVWL | ||||||
Chain | PRO_0000042782 | 30-420 | Protein disulfide isomerase Creld1 | |||
Sequence: QPSPPPHPSPRAEPHPCHTCRALVDNFNKGLERTIRDNFGGGNTAWEEEKLSKYKDSETRLVEVLEGVCSRSDFECHRLLELSEELVENWWFHRQQEAPDLFQWLCSDSLKLCCPSGTFGPSCLPCPGGTERPCGGYGQCEGEGTRGGSGHCDCQAGYGGEACGQCGLGYFEAERNSSHLVCSACFGPCARCTGPEESHCLQCKKGWALHHLKCVDIDECGTEQATCGADQFCVNTEGSYECRDCAKACLGCMGAGPGRCKKCSRGYQQVGSKCLDVDECETVVCPGENEKCENTEGGYRCVCAEGYRQEDGICVKEQVPESAGFFAEMTEDEMVVLQQMFFGVIICALATLAAKGDLVFTAIFIGAVAAMTGYWLSERSDRVLEGFIKGR | ||||||
Disulfide bond | 46↔49 | Redox-active | ||||
Sequence: CHTC | ||||||
Disulfide bond | 155↔169 | |||||
Sequence: CPGGTERPCGGYGQC | ||||||
Disulfide bond | 163↔181 | |||||
Sequence: CGGYGQCEGEGTRGGSGHC | ||||||
Disulfide bond | 183↔192 | |||||
Sequence: CQAGYGGEAC | ||||||
Glycosylation | 205 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 278↔281 | Redox-active | ||||
Sequence: CLGC | ||||||
Disulfide bond | 309↔321 | |||||
Sequence: CETVVCPGENEKC | ||||||
Disulfide bond | 314↔330 | |||||
Sequence: CPGENEKCENTEGGYRC | ||||||
Disulfide bond | 332↔343 | |||||
Sequence: CAEGYRQEDGIC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in myoblast C2C12 cells (at protein level).
Gene expression databases
Structure
Family & Domains
Features
Showing features for motif, domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 46-49 | CXXC | ||||
Sequence: CHTC | ||||||
Domain | 153-193 | EGF-like 1 | ||||
Sequence: LPCPGGTERPCGGYGQCEGEGTRGGSGHCDCQAGYGGEACG | ||||||
Repeat | 208-255 | FU 1 | ||||
Sequence: HLVCSACFGPCARCTGPEESHCLQCKKGWALHHLKCVDIDECGTEQAT | ||||||
Repeat | 268-315 | FU 2 | ||||
Sequence: SYECRDCAKACLGCMGAGPGRCKKCSRGYQQVGSKCLDVDECETVVCP | ||||||
Motif | 278-281 | CXXC | ||||
Sequence: CLGC | ||||||
Domain | 305-342 | EGF-like 2; calcium-binding | ||||
Sequence: DVDECETVVCPGENEKCENTEGGYRCVCAEGYRQEDGI |
Sequence similarities
Belongs to the CRELD family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length420
- Mass (Da)45,718
- Last updated2001-12-01 v1
- Checksum4066BF2D739D3179
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AA74KSI5 | A0AA74KSI5_MOUSE | Creld1 | 240 | ||
A0A9L6KDX8 | A0A9L6KDX8_MOUSE | Creld1 | 378 | ||
A0A9L6KDL3 | A0A9L6KDL3_MOUSE | Creld1 | 337 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK050160 EMBL· GenBank· DDBJ | BAC34101.1 EMBL· GenBank· DDBJ | mRNA | ||
AK050455 EMBL· GenBank· DDBJ | BAC34266.1 EMBL· GenBank· DDBJ | mRNA | ||
AK155777 EMBL· GenBank· DDBJ | BAE33433.1 EMBL· GenBank· DDBJ | mRNA | ||
BC010804 EMBL· GenBank· DDBJ | AAH10804.1 EMBL· GenBank· DDBJ | mRNA | ||
BC023893 EMBL· GenBank· DDBJ | AAH23893.1 EMBL· GenBank· DDBJ | mRNA | ||
BC025932 EMBL· GenBank· DDBJ | AAH25932.1 EMBL· GenBank· DDBJ | mRNA | ||
BC029065 EMBL· GenBank· DDBJ | AAH29065.1 EMBL· GenBank· DDBJ | mRNA |