Nucleotide sequence and peptide motifs of mouse uromodulin (Tamm-Horsfall protein) -- the most abundant protein in mammalian urine.Prasadan K., Bates J., Badgett A., Dell M., Sukhatme V., Yu H., Kumar S.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA]CategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochim. Biophys. Acta 1260:328-332 (1995)Cited in1Mapped to3
The transcriptional landscape of the mammalian genome.Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B.[...], Hayashizaki Y.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]StrainC57BL/6JTissueKidneyCategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 309:1559-1563 (2005)Cited in99+16Mapped to99+
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]StrainFVB/NTissueLiverCategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin Ia and Ib receptors.Pak J., Pu Y., Zhang Z.T., Hasty D.L., Wu X.R.View abstractCited forFUNCTIONCategoryFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 276:9924-9930 (2001)Cited in2Mapped to1
The ZP domain is a conserved module for polymerization of extracellular proteins.Jovine L., Qi H., Williams Z., Litscher E., Wassarman P.M.View abstractCited forGLYCOSYLATION, DOMAIN ZPCategoriesPTM / Processing, Family & DomainsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Cell Biol. 4:457-461 (2002)Cited in1Mapped to4
Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication.Bates J.M., Raffi H.M., Prasadan K., Mascarenhas R., Laszik Z., Maeda N., Hultgren S.J., Kumar S.View abstractCited forDISRUPTION PHENOTYPE, FUNCTIONCategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCKidney Int. 65:791-797 (2004)Cited in1Mapped to5
Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation.Mo L., Huang H.Y., Zhu X.H., Shapiro E., Hasty D.L., Wu X.R.View abstractCited forDISRUPTION PHENOTYPE, FUNCTIONCategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCKidney Int. 66:1159-1166 (2004)Cited in1Mapped to5
Urinary uromodulin carries an intact ZP domain generated by a conserved C- terminal proteolytic cleavage.Santambrogio S., Cattaneo A., Bernascone I., Schwend T., Jovine L., Bachi A., Rampoldi L.View abstractCited forPROTEIN SEQUENCE OF 573-587, PROTEOLYTIC CLEAVAGE, IDENTIFICATION BY MASS SPECTROMETRYCategoriesPTM / Processing, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochem. Biophys. Res. Commun. 370:410-413 (2008)Cited in2Mapped to7
A tissue-specific atlas of mouse protein phosphorylation and expression.Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.View abstractCited forIDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]TissueKidneyCategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 143:1174-1189 (2010)Cited in99+99+Mapped to6
The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin.Brunati M., Perucca S., Han L., Cattaneo A., Consolato F., Andolfo A., Schaeffer C., Olinger E., Peng J.[...], Rampoldi L.View abstractCited forSUBUNIT, SUBCELLULAR LOCATION, GLYCOSYLATION, IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY, DOMAINCategoriesPTM / Processing, Family & Domains, Sequences, Expression, Interaction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCElife 4:0-0 (2015)Cited in4Mapped to21
Assignment of the Tamm-Horsfall protein/uromodulin gene (Umod) to mouse chromosome bands 7F1-F2 and rat chromosome bands 1q36-->q37 by in situ hybridization.Fukuoka S., Matsuda Y.CategorySequencesSourceMGI: 102674PubMedEurope PMCCytogenet Cell Genet 79:241-242 (1997)Mapped to4
Report and abstracts of the third international workshop on human chromosome 16 mapping 1994. Pittsburgh, Pennsylvania, May 7-9, 1994.Doggett N.A., Callen D.F.CategorySequencesSourceMGI: 102674PubMedEurope PMCCytogenet Cell Genet 68:165-184 (1995)Mapped to38
Cloning, embryonic expression, and alternative splicing of a murine kidney-specific Na-K-Cl cotransporter.Igarashi P., Vanden Heuvel G.B., Payne J.A., Forbush B. IIIView abstractCategoriesSequences, ExpressionSourceMGI: 102674PubMedEurope PMCAm. J. Physiol. 269:F405-F418 (1995)Cited in1Mapped to15
Role of NF-kappa B in the regulation of inducible nitric oxide synthase in an MTAL cell line.Kone B.C., Schwoebel J., Turner P., Mohaupt M.G., Cangro C.B.View abstractCategoriesFunction, ExpressionSourceMGI: 102674PubMedEurope PMCAm. J. Physiol. 269:F718-F729 (1995)Cited in11Mapped to14
Increased water intake dilutes protective uromodulin levels in urine and results in increased rates of pyelonephritis in a murine model.Hamilton A.D.K., Sparsoe L.V., Skov M., Johnsen N., Chreistensen M.H., Corydon T.J., Praetorius H.View abstractAnnotationIncreased water intake dilutes protective uromodulin levels in urine and results in increased rates of pyelonephritis in a murine model.SourceGeneRif: 22242PubMedEurope PMCActa Physiol (Oxf) 240:e14204-e14204 (2024)Mapped to3
Expression pattern of Runt-related transcription factor (RUNX) family members and the role of RUNX1 during kidney development.Yano-Sakamoto K., Kitai Y., Toriu N., Yamamoto S., Mizuta K., Saitou M., Tsukiyama T., Taniuchi I., Osato M., Yanagita M.View abstractCategoryFunctionSourceMGI: 102674PubMedEurope PMCBiochem Biophys Res Commun 722:150155-150155 (2024)Mapped to99+
Genetic determinants of micronucleus formation in vivo.Adams D.J., Barlas B., McIntyre R.E., Salguero I., van der Weyden L., Barros A., Vicente J.R., Karimpour N., Haider A.[...], White J.K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 102674PubMedEurope PMCNature 627:130-136 (2024)Mapped to99+
Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease.Schiano G., Lake J., Mariniello M., Schaeffer C., Harvent M., Rampoldi L., Olinger E., Devuyst O.View abstractAnnotationAllelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease.CategoryFunctionSourceGeneRif: 22242, MGI: 102674PubMedEurope PMCEMBO Mol Med 15:e18242-e18242 (2023)Mapped to6
MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice.Kim Y., Li C., Gu C., Fang Y., Tycksen E., Puri A., Pietka T.A., Sivapackiam J., Kidd K.[...], Chen Y.M.View abstractCategoryFunctionSourceMGI: 102674PubMedEurope PMCNat Commun 14:6493-6493 (2023)Mapped to10
Smarca4 deficiency induces Pttg1 oncogene upregulation and hyperproliferation of tubular and interstitial cells during kidney development.Xu J., Zhou X., Zhang T., Zhang B., Xu P.X.View abstractCategoryFunctionSourceMGI: 102674PubMedEurope PMCFront Cell Dev Biol 11:1233317-1233317 (2023)Mapped to99+
Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment.Liang X., Aranyi T., Zhou J., Guan Y., Hu H., Liu H., Susztak K.View abstractCategoryFunctionSourceMGI: 102674PubMedEurope PMCJ Am Soc Nephrol 34:572-589 (2023)Mapped to99+
ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis.Kumar S., Fan X., Rasouly H.M., Sharma R., Salant D.J., Lu W.View abstractCategoryFunctionSourceMGI: 102674PubMedEurope PMCJCI Insight 8:e158418-e158418 (2023)Mapped to99+
Uromodulin Regulates Murine Aquaporin-2 Activity via Thick Ascending Limb- Collecting Duct Cross-Talk during Water Deprivation.Takata T., Hamada S., Mae Y., Iyama T., Ogihara R., Seno M., Nakamura K., Takata M., Sugihara T., Isomoto H.View abstractAnnotationUromodulin Regulates Murine Aquaporin-2 Activity via Thick Ascending Limb-Collecting Duct Cross-Talk during Water Deprivation.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 22242, MGI: 102674PubMedEurope PMCInt J Mol Sci 23:9410-9410 (2022)Mapped to8
NHE3 in the thick ascending limb is required for sustained but not acute furosemide-induced urinary acidification.Xue J., Thomas L., Dominguez Rieg J.A., Fenton R.A., Rieg T.View abstractSourceMGI: 102674PubMedEurope PMCAm J Physiol Renal Physiol 323:F141-F155 (2022)Mapped to7
High-resolution Slide-seqV2 spatial transcriptomics enables discovery of disease-specific cell neighborhoods and pathways.Marshall J.L., Noel T., Wang Q.S., Chen H., Murray E., Subramanian A., Vernon K.A., Bazua-Valenti S., Liguori K.[...], Greka A.View abstractCategoriesFunction, ExpressionSourceMGI: 102674PubMedEurope PMCiScience 25:104097-104097 (2022)Mapped to9