t3gal2-null mice display a reduced respiratory exchange ratio compared to WT mice indicating a preference for lipid oxidation as an energy source. Despite their altered metabolism St3gal2-null mice were hyperactive. We conclude that altered ganglioside expression in adipose tissue results in diminished IR sensitivity and late-onset obesity.
St3gal2/3 double-null mice displayed dysmyelination marked by a reduction in major myelin proteins fewer myelinated axons a decrease in myelin thickness possibly by dysregulation of ganglioside-mediated oligodendroglial precursor cell proliferation.
was not found to play a role in regulating synthesis of selectin ligands nor in vitro rolling of marrow-derived neutrophils on E- or P-selectins presented by Chinese hamster ovary cells
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