Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L.[...], Ponting C.P.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainC57BL/6JCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPLoS Biol. 7:E1000112-E1000112 (2009)Cited in99+99+
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 219-354StrainFVB/NTissueMammary tumorCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
The HIN-200 family: more than interferon-inducible genes?Ludlow L.E.A., Johnstone R.W., Clarke C.J.P.View abstractCited forIDENTIFICATIONSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCExp. Cell Res. 308:1-17 (2005)Cited in2Mapped to3
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.Fernandes-Alnemri T., Yu J.W., Datta P., Wu J., Alnemri E.S.View abstractCited forFUNCTION, ACTIVITY REGULATIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 458:509-513 (2009)Cited in3Mapped to5
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.Hornung V., Ablasser A., Charrel-Dennis M., Bauernfeind F., Horvath G., Caffrey D.R., Latz E., Fitzgerald K.A.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 458:514-518 (2009)Cited in3Mapped to24
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.Burckstummer T., Baumann C., Bluml S., Dixit E., Durnberger G., Jahn H., Planyavsky M., Bilban M., Colinge J.[...], Superti-Furga G.View abstractCited forFUNCTION, SUBCELLULAR LOCATIONCategoriesFunction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Immunol. 10:266-272 (2009)Cited in2Mapped to72
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA.Roberts T.L., Idris A., Dunn J.A., Kelly G.M., Burnton C.M., Hodgson S., Hardy L.L., Garceau V., Sweet M.J.[...], Stacey K.J.View abstractCited forFUNCTION, ACTIVITY REGULATIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 323:1057-1060 (2009)Cited in2Mapped to12
Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol.Sauer J.D., Witte C.E., Zemansky J., Hanson B., Lauer P., Portnoy D.A.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell Host Microbe 7:412-419 (2010)Cited in1Mapped to3
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis.Fernandes-Alnemri T., Yu J.W., Juliana C., Solorzano L., Kang S., Wu J., Datta P., McCormick M., Huang L.[...], Alnemri E.S.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Immunol. 11:385-393 (2010)Cited in1Mapped to9
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.Rathinam V.A., Jiang Z., Waggoner S.N., Sharma S., Cole L.E., Waggoner L., Vanaja S.K., Monks B.G., Ganesan S.[...], Fitzgerald K.A.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Immunol. 11:395-402 (2010)Cited in1Mapped to25
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.Jones J.W., Kayagaki N., Broz P., Henry T., Newton K., O'Rourke K., Chan S., Dong J., Qu Y.[...], Monack D.M.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 107:9771-9776 (2010)Cited in1Mapped to30
AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages.Pierini R., Juruj C., Perret M., Jones C.L., Mangeot P., Weiss D.S., Henry T.View abstractCited forFUNCTION, SUBCELLULAR LOCATIONCategoriesFunction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell Death Differ. 19:1709-1721 (2012)Cited in2Mapped to28
Francisella infection triggers activation of the AIM2 inflammasome in murine dendritic cells.Belhocine K., Monack D.M.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell. Microbiol. 14:71-80 (2012)Cited in1Mapped to14
Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation.Yin Q., Sester D.P., Tian Y., Hsiao Y.S., Lu A., Cridland J.A., Sagulenko V., Thygesen S.J., Choubey D.[...], Wu H.View abstractCited forACTIVITY REGULATION, INTERACTION WITH IFI202CategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell Rep. 4:327-339 (2013)Cited in2Mapped to6
Critical role for the DNA sensor AIM2 in stem cell proliferation and cancer.Man S.M., Zhu Q., Zhu L., Liu Z., Karki R., Malik A., Sharma D., Li L., Malireddi R.K.[...], Kanneganti T.D.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 162:45-58 (2015)Cited in2Mapped to36
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.Wilson J.E., Petrucelli A.S., Chen L., Koblansky A.A., Truax A.D., Oyama Y., Rogers A.B., Brickey W.J., Wang Y.[...], Ting J.P.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Med. 21:906-913 (2015)Cited in2Mapped to28
AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity.Di Micco A., Frera G., Lugrin J., Jamilloux Y., Hsu E.T., Tardivel A., De Gassart A., Zaffalon L., Bujisic B.[...], Martinon F.View abstractCited forACTIVITY REGULATIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 113:E4671-E4680 (2016)Cited in2Mapped to19
The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.Hu B., Jin C., Li H.B., Tong J., Ouyang X., Cetinbas N.M., Zhu S., Strowig T., Lam F.C.[...], Flavell R.A.View abstractCited forFUNCTION, ACTIVITY REGULATION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & Variants, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 354:765-768 (2016)Cited in1Mapped to27
AIM 2 inflammasomes regulate neuronal morphology and influence anxiety and memory in mice.Wu P.J., Liu H.Y., Huang T.N., Hsueh Y.P.View abstractCited forTISSUE SPECIFICITY, DISRUPTION PHENOTYPECategoriesExpression, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCSci. Rep. 6:32405-32405 (2016)Cited in1Mapped to1
Oxysterol restraint of cholesterol synthesis prevents AIM2 inflammasome activation.Dang E.V., McDonald J.G., Russell D.W., Cyster J.G.View abstractCited forACTIVITY REGULATIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 171:1057-1071 (2017)Cited in2Mapped to25
AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment.Lammert C.R., Frost E.L., Bellinger C.E., Bolte A.C., McKee C.A., Hurt M.E., Paysour M.J., Ennerfelt H.E., Lukens J.R.View abstractCited forFUNCTION, ACTIVITY REGULATION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 580:647-652 (2020)Cited in2Mapped to6
AIM2 in regulatory T cells restrains autoimmune diseases.Chou W.C., Guo Z., Guo H., Chen L., Zhang G., Liang K., Xie L., Tan X., Gibson S.A.[...], Ting J.P.View abstractCited forFUNCTION, INTERACTION WITH RACK1, TISSUE SPECIFICITY, INDUCTIONCategoriesFunction, Expression, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 591:300-305 (2021)Cited in4Mapped to5
Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome.Wang L.Q., Liu T., Yang S., Sun L., Zhao Z.Y., Li L.Y., She Y.C., Zheng Y.Y., Ye X.Y.[...], Cui J.View abstractCited forFUNCTION, ACTIVITY REGULATIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Commun. 12:2915-2915 (2021)Cited in1Mapped to9
AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.Lee S., Karki R., Wang Y., Nguyen L.N., Kalathur R.C., Kanneganti T.D.View abstractCited forFUNCTION, IDENTIFICATION IN THE AIM2 PANOPTOSOME COMPLEXCategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 597:415-419 (2021)Cited in9Mapped to16
Structural basis for termination of AIM2-mediated signaling by p202.Ru H., Ni X., Zhao L., Crowley C., Ding W., Hung L.W., Shaw N., Cheng G., Liu Z.J.Cited forX-RAY CRYSTALLOGRAPHY (2.22 ANGSTROMS) OF 158-349 IN COMPLEX WITH DNA, FUNCTION, DOMAIN, DNA-BINDINGCategoriesFunction, Family & Domains, Interaction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell Res. 23:855-858 (2013)Cited in2Mapped to6