Q91V57 · CHIN_MOUSE

  • Protein
    N-chimaerin
  • Gene
    Chn1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

GTPase-activating protein for p21-rac and a phorbol ester receptor. May play an important role in neuronal signal-transduction mechanisms (By similarity).
Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionephrin receptor binding
Molecular FunctionGTPase activator activity
Molecular Functionmetal ion binding
Biological Processephrin receptor signaling pathway
Biological Processmotor neuron axon guidance
Biological Processregulation of axonogenesis
Biological Processregulation of GTPase activity
Biological Processregulation of small GTPase mediated signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-chimaerin
  • Alternative names
    • A-chimaerin
    • Alpha-chimerin
    • N-chimerin (NC)
    • Rho GTPase-activating protein 2

Gene names

    • Name
      Chn1
    • Synonyms
      Arhgap2

Organism names

  • Taxonomic identifier
  • Strains
    • ILS
    • ISS
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q91V57
  • Secondary accessions
    • A2ATM0
    • Q3UGY3
    • Q7TQE5
    • Q8BWU6
    • Q9D9B3

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

Mice are viable and fertile but display a loss of coordination of limb movement which phenocopies the one of Epha4 mutant mice.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 13 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylalanine
ChainPRO_00000566952-459N-chimaerin
Modified residue192Phosphothreonine
Modified residue340Phosphothreonine

Post-translational modification

Phosphorylated. Phosphorylation is EPHA4 kinase activity-dependent.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation. May also interact with EPHB1 and EPHB2.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q91V57-1Epha4 Q031372EBI-1539203, EBI-1539152

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, zinc finger.

TypeIDPosition(s)Description
Domain49-135SH2
Zinc finger205-255Phorbol-ester/DAG-type
Domain268-459Rho-GAP

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q91V57-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    459
  • Mass (Da)
    53,193
  • Last updated
    2006-09-05 v2
  • Checksum
    EE10CCDA8229C0B0
MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRVTCTCEVENRPKYYGREYHGMISREETDQLLSVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHIGYTTLNREPAYKQHMAVLKETHDEKEATGQDGVSEKRLTSLVRRATLKENEQIPKYEKVHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHITKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALRSLPPAHCETLRYLMAHLKRVTLHEKENLMSAENLGIVFGPTLMRSPELDPMAALNDIRYQRLVVELLIKNEDILF

Q91V57-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-183: MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRVTCTCEVENRPKYYGREYHGMISREETDQLLSVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHIGYTTLNREPAYKQHMAVLKETHDEKEATGQDGVSEKR → MPSKESWSGRKANRATVHKAKPEGRQQGLLIAALGMKLGSQKSSVTIWQPLKLFAYSQ

Q91V57-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A7VK13A7VK13_MOUSEChn1401
B2FDI0B2FDI0_MOUSEChn195
B2FDI1B2FDI1_MOUSEChn181
B2FDI2B2FDI2_MOUSEChn1128
D6RCX8D6RCX8_MOUSEChn187
F7C3N6F7C3N6_MOUSEChn129

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0201451-183in isoform 2
Alternative sequenceVSP_0201461-249in isoform 3
Sequence conflict253in Ref. 4; AAH54770
Sequence conflict275in Ref. 2; BAE28074
Sequence conflict331in Ref. 2; BAC33996

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF332069
EMBL· GenBank· DDBJ
AAK56097.1
EMBL· GenBank· DDBJ
mRNA
AF332070
EMBL· GenBank· DDBJ
AAK56098.1
EMBL· GenBank· DDBJ
mRNA
AK049943
EMBL· GenBank· DDBJ
BAC33996.1
EMBL· GenBank· DDBJ
mRNA
AK007182
EMBL· GenBank· DDBJ
BAB24888.1
EMBL· GenBank· DDBJ
mRNA
AK075606
EMBL· GenBank· DDBJ
BAC35853.1
EMBL· GenBank· DDBJ
mRNA
AK147686
EMBL· GenBank· DDBJ
BAE28074.1
EMBL· GenBank· DDBJ
mRNA
AL928889
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC010825
EMBL· GenBank· DDBJ
AAH10825.1
EMBL· GenBank· DDBJ
mRNA
BC024796
EMBL· GenBank· DDBJ
AAH24796.1
EMBL· GenBank· DDBJ
mRNA
BC025023
EMBL· GenBank· DDBJ
AAH25023.1
EMBL· GenBank· DDBJ
mRNA
BC054770
EMBL· GenBank· DDBJ
AAH54770.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp