Q91989 · P5F13_XENLA

Function

function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Antagonizes the activity of nodal/activin signaling during gastrulation to suppress mesendoderm formation. Acts maternally to inhibit vegt and beta-catenin-activated gene transcription, probably by forming a transcriptional repression complex on the promoters of target genes. Binds to an octamer motif in interspersed RNA.

Features

Showing features for dna binding.

142650100150200250300350400
TypeIDPosition(s)Description
DNA binding296-355Homeobox

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Cellular Componenttranscription regulator complex
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor binding
Molecular FunctionRNA binding
Molecular Functionsequence-specific DNA binding
Molecular Functiontranscription cis-regulatory region binding
Biological Processcell differentiation
Biological Processnegative regulation of activin receptor signaling pathway
Biological Processnegative regulation of DNA-templated transcription

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    POU domain, class 5, transcription factor 1.3
  • Alternative names
    • POU class V protein oct-60
      (XOct-60
      ; XlPOU-60)

Gene names

    • Name
      pou5f1.3
    • Synonyms
      oct-60

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    Q91989
  • Secondary accessions
    • Q03916

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003909341-426POU domain, class 5, transcription factor 1.3

Expression

Tissue specificity

Expressed in the animal half of oocytes and remains localized to the animal cap and marginal zone of blastula embryos. Expressed in the adult ovary and at a very low level in the adult kidney. Absent from primordial germ cells (PGCs).

Developmental stage

Expressed maternally. Most abundant in oocytes and fertilized eggs, with expression maintained through the cleavage stages of development until early gastrulation. Expression levels drop abruptly during gastrulation (stage 11) but remain at very low levels through larval stages.

Gene expression databases

    • 397936Expressed in blastula and 9 other cell types or tissues

Interaction

Subunit

Interacts with the transcription factors tcf7l1/tcf3 and vegt.

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region82-118Disordered
Compositional bias104-118Polar residues
Region140-203Disordered
Compositional bias153-175Polar residues
Compositional bias183-199Polar residues
Domain202-276POU-specific

Sequence similarities

Belongs to the POU transcription factor family. Class-5 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    426
  • Mass (Da)
    47,253
  • Last updated
    1996-11-01 v1
  • Checksum
    D8C2D596B3BD56C7
MDQPILYSQTSFPNFTYSPGVVQDGGNYQYLGNYNAPSYPQPFFHVPVIKSEFGAHEEETPGSCHAASFDWNLYPHFQISNQAASNSSGDPSPEGRTEEDGSVSEGRSSSSPSPNSPLVPSFAQYWHYPSWQQGNLTNQAHTLFDGGDEKPQQSRHSPTASLGSGASNTEDEEVPSAISSRAERGLCSPSPNNASCGPGTEEDGMTLEEMEEFAKELKQKRVALGYTQGDIGHALGILYGKMFSQTTICRFESLQLTFKNMCKLKPLLEQWLGEAENNDNLQEMIHKAQIEEQNRKRKMRTCFDTVLKGQLEGHFMCNQKPGARELTEIAKELSLEKDVVRVWFCNRRQKEKSKFRMSKGHEFVGGASPGSIQSEHISFTPIPANSQDYGLASLHPNRAPFYPPPFPRNELFPHMAPGISMGVLTG

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias104-118Polar residues
Sequence conflict140in Ref. 1; AAA49997
Compositional bias153-175Polar residues
Compositional bias183-199Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M60075
EMBL· GenBank· DDBJ
AAA49997.1
EMBL· GenBank· DDBJ
mRNA
X86377
EMBL· GenBank· DDBJ
CAA60136.1
EMBL· GenBank· DDBJ
mRNA
BC070557
EMBL· GenBank· DDBJ
AAH70557.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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