Q91989 · P5F13_XENLA
- ProteinPOU domain, class 5, transcription factor 1.3
- Genepou5f1.3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids426 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Antagonizes the activity of nodal/activin signaling during gastrulation to suppress mesendoderm formation. Acts maternally to inhibit vegt and beta-catenin-activated gene transcription, probably by forming a transcriptional repression complex on the promoters of target genes. Binds to an octamer motif in interspersed RNA.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 296-355 | Homeobox | ||||
Sequence: KRKMRTCFDTVLKGQLEGHFMCNQKPGARELTEIAKELSLEKDVVRVWFCNRRQKEKSKF |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | transcription regulator complex | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | DNA-binding transcription factor binding | |
Molecular Function | RNA binding | |
Molecular Function | sequence-specific DNA binding | |
Molecular Function | transcription cis-regulatory region binding | |
Biological Process | cell differentiation | |
Biological Process | negative regulation of activin receptor signaling pathway | |
Biological Process | negative regulation of DNA-templated transcription |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended namePOU domain, class 5, transcription factor 1.3
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus
Accessions
- Primary accessionQ91989
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000390934 | 1-426 | POU domain, class 5, transcription factor 1.3 | |||
Sequence: MDQPILYSQTSFPNFTYSPGVVQDGGNYQYLGNYNAPSYPQPFFHVPVIKSEFGAHEEETPGSCHAASFDWNLYPHFQISNQAASNSSGDPSPEGRTEEDGSVSEGRSSSSPSPNSPLVPSFAQYWHYPSWQQGNLTNQAHTLFDGGDEKPQQSRHSPTASLGSGASNTEDEEVPSAISSRAERGLCSPSPNNASCGPGTEEDGMTLEEMEEFAKELKQKRVALGYTQGDIGHALGILYGKMFSQTTICRFESLQLTFKNMCKLKPLLEQWLGEAENNDNLQEMIHKAQIEEQNRKRKMRTCFDTVLKGQLEGHFMCNQKPGARELTEIAKELSLEKDVVRVWFCNRRQKEKSKFRMSKGHEFVGGASPGSIQSEHISFTPIPANSQDYGLASLHPNRAPFYPPPFPRNELFPHMAPGISMGVLTG |
Expression
Tissue specificity
Expressed in the animal half of oocytes and remains localized to the animal cap and marginal zone of blastula embryos. Expressed in the adult ovary and at a very low level in the adult kidney. Absent from primordial germ cells (PGCs).
Developmental stage
Expressed maternally. Most abundant in oocytes and fertilized eggs, with expression maintained through the cleavage stages of development until early gastrulation. Expression levels drop abruptly during gastrulation (stage 11) but remain at very low levels through larval stages.
Gene expression databases
Interaction
Subunit
Interacts with the transcription factors tcf7l1/tcf3 and vegt.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 82-118 | Disordered | ||||
Sequence: QAASNSSGDPSPEGRTEEDGSVSEGRSSSSPSPNSPL | ||||||
Compositional bias | 104-118 | Polar residues | ||||
Sequence: SEGRSSSSPSPNSPL | ||||||
Region | 140-203 | Disordered | ||||
Sequence: AHTLFDGGDEKPQQSRHSPTASLGSGASNTEDEEVPSAISSRAERGLCSPSPNNASCGPGTEED | ||||||
Compositional bias | 153-175 | Polar residues | ||||
Sequence: QSRHSPTASLGSGASNTEDEEVP | ||||||
Compositional bias | 183-199 | Polar residues | ||||
Sequence: ERGLCSPSPNNASCGPG | ||||||
Domain | 202-276 | POU-specific | ||||
Sequence: EDGMTLEEMEEFAKELKQKRVALGYTQGDIGHALGILYGKMFSQTTICRFESLQLTFKNMCKLKPLLEQWLGEAE |
Sequence similarities
Belongs to the POU transcription factor family. Class-5 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length426
- Mass (Da)47,253
- Last updated1996-11-01 v1
- ChecksumD8C2D596B3BD56C7
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 104-118 | Polar residues | ||||
Sequence: SEGRSSSSPSPNSPL | ||||||
Sequence conflict | 140 | in Ref. 1; AAA49997 | ||||
Sequence: A → P | ||||||
Compositional bias | 153-175 | Polar residues | ||||
Sequence: QSRHSPTASLGSGASNTEDEEVP | ||||||
Compositional bias | 183-199 | Polar residues | ||||
Sequence: ERGLCSPSPNNASCGPG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M60075 EMBL· GenBank· DDBJ | AAA49997.1 EMBL· GenBank· DDBJ | mRNA | ||
X86377 EMBL· GenBank· DDBJ | CAA60136.1 EMBL· GenBank· DDBJ | mRNA | ||
BC070557 EMBL· GenBank· DDBJ | AAH70557.1 EMBL· GenBank· DDBJ | mRNA |