Q91677 · GATA4_XENLA
- ProteinTranscription factor GATA-4
- Genegata4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids392 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3'. Associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis. Activates the expression of cardiac MHC-alpha in vivo.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | transcription cis-regulatory region binding | |
Molecular Function | zinc ion binding | |
Biological Process | canonical Wnt signaling pathway | |
Biological Process | cardiac muscle tissue development | |
Biological Process | positive regulation of DNA-templated transcription | |
Biological Process | positive regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTranscription factor GATA-4
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus
Accessions
- Primary accessionQ91677
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000083417 | 1-392 | Transcription factor GATA-4 | |||
Sequence: MYQSIAMATNHGPSGYEGTGSFMHSATAATSPVYVPTTRVSSMIHSLPYLQTSGSSQQGSPVSGHNMWAQAGVESSAYNPGTSHPPVSPRFTFSSSPPITAPSSREVSYSSPLGISANGREQYSRGLGATYASPYPAYMSPDMGAAWTASPFDSSMLHNLQNRAVTSRHPNIEFFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCHTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMKKEGIQTRKRKPKNLSKSKTLTGQSGSDSLTPSTSSTNSMGEEMRPIKIEPGLSPPYDHSNSISQASALSTITSHGSSYYPMPSLKLSPQNHHSTFNPSPQANSKHDSWNNLVLA |
Expression
Tissue specificity
Expressed at high levels in heart, small intestine, stomach, ovary, and liver. Found at much lower levels in lung, spleen, pancreas and skin.
Developmental stage
Expressed in cardiac progenitors during embryogenesis and up-regulated during gastrulation.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, zinc finger, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 75-113 | Disordered | ||||
Sequence: SSAYNPGTSHPPVSPRFTFSSSPPITAPSSREVSYSSPL | ||||||
Zinc finger | 184-208 | GATA-type 1 | ||||
Sequence: CVNCGAMSTPLWRRDGTGHYLCNAC | ||||||
Zinc finger | 238-262 | GATA-type 2 | ||||
Sequence: CANCHTTTTTLWRRNAEGEPVCNAC | ||||||
Region | 279-339 | Disordered | ||||
Sequence: KEGIQTRKRKPKNLSKSKTLTGQSGSDSLTPSTSSTNSMGEEMRPIKIEPGLSPPYDHSNS | ||||||
Compositional bias | 294-319 | Polar residues | ||||
Sequence: KSKTLTGQSGSDSLTPSTSSTNSMGE | ||||||
Region | 359-392 | Disordered | ||||
Sequence: MPSLKLSPQNHHSTFNPSPQANSKHDSWNNLVLA |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length392
- Mass (Da)42,353
- Last updated1997-11-01 v1
- Checksum26BFD5AEBA57C2B6
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 294-319 | Polar residues | ||||
Sequence: KSKTLTGQSGSDSLTPSTSSTNSMGE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U45453 EMBL· GenBank· DDBJ | AAB05647.1 EMBL· GenBank· DDBJ | mRNA |