Q91287 · FGFR3_PLEWA

Function

function

Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity).

Catalytic activity

Activity regulation

Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity).

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site463-471ATP (UniProtKB | ChEBI)
Binding site493ATP (UniProtKB | ChEBI)
Active site602Proton acceptor

GO annotations

AspectTerm
Cellular Componentplasma membrane
Cellular Componentreceptor complex
Molecular FunctionATP binding
Molecular Functionfibroblast growth factor binding
Molecular Functionfibroblast growth factor receptor activity
Biological Processapoptotic process
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of kinase activity
Biological Processpositive regulation of MAPK cascade
Biological Processprotein phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fibroblast growth factor receptor 3
  • EC number
  • Short names
    FGFR-3
  • Alternative names
    • PFR3

Gene names

    • Name
      FGFR3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Caudata > Salamandroidea > Salamandridae > Pleurodelinae > Pleurodeles

Accessions

  • Primary accession
    Q91287

Subcellular Location

Cell membrane
; Single-pass type I membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain20-358Extracellular
Transmembrane359-379Helical
Topological domain380-796Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, modified residue.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_000024921820-796Fibroblast growth factor receptor 3
Disulfide bond56↔102
Glycosylation91N-linked (GlcNAc...) asparagine
Glycosylation113N-linked (GlcNAc...) asparagine
Disulfide bond165↔217
Glycosylation214N-linked (GlcNAc...) asparagine
Glycosylation251N-linked (GlcNAc...) asparagine
Disulfide bond264↔328
Glycosylation283N-linked (GlcNAc...) asparagine
Glycosylation304N-linked (GlcNAc...) asparagine
Glycosylation317N-linked (GlcNAc...) asparagine
Modified residue632Phosphotyrosine; by autocatalysis
Modified residue633Phosphotyrosine; by autocatalysis
Modified residue709Phosphotyrosine; by autocatalysis
Modified residue745Phosphotyrosine; by autocatalysis

Post-translational modification

Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer (By similarity).

Keywords

PTM databases

Expression

Tissue specificity

Undetectable in the adult skeletal muscle. Low levels of expression were detected in the liver, lung and kidney. Medium levels of expression were detected in the heart, spleen, intestine and eye. Highest expression is observed in the testis.

Developmental stage

Maternally transcript whose a low level of expression persists during the cleavage and gastrula stages and a significant increase was observed at the end of the gastrula stage. Mainly localized to the ectoderm at the early gastrula stage and then shifted to the embryonic neural tissues, whereas adult brain had decreased levels of expression. Strong expression in the germinal epithelium of the embryonic brain (especially the diencephalon and rhombencephalon) and neural tube, in the lens and the cranial ganglia. The epithelium of the developing gut, like the pharynx and esophagus, also prominently expressed it. Other sites of expression were found in the liver and in the mesenchymal condensation sites of branchial arches.

Interaction

Subunit

Monomer. Homodimer after ligand binding (By similarity).

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain21-119Ig-like C2-type 1
Region117-142Disordered
Domain140-233Ig-like C2-type 2
Domain239-344Ig-like C2-type 3
Domain457-746Protein kinase

Domain

The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans.

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    796
  • Mass (Da)
    88,289
  • Last updated
    1996-11-01 v1
  • Checksum
    226D99A0B6D1D92D
MLVWLCGLCLVTLAGGRSAARLPLTEGRPTADFLPGDASLVEELLFGTGDTIELSCTTPGSSVSVVWFKDGISVDPPTWSHTGQKLLKIINVSYDDSGVYSCKARQSSEVLRNVTVRVTDSPSSGDDEDDDEESESANAPKFTRPEWMEKKLLAVPAANTVRFRCPAAGKPTPSITWLKNGKEFKGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVANKYGTIRETYTLDVLERTPHRPILQAGFRSNKTVVVGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKFGPDGNPYVTVLKTAGVNTSDKELEIQFLRNVTFEDAGEYTCLAGNSIGYSHHSAWLTVLPPAEPVPDVDTSVSILAAAGCVAVVILVVIIIFTYKMKMPSKKTMNTATVHKVSKFPLKRQVSLESNSSMNSNTPLVRITRLSSSDGPMLANVSELELPADPKWELSRSRLTLGKPLGEGCFGQVVMADAVGIEKDKPNKATSVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKLPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTDDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSVPFEQYSPACPDSHSSCSSGDDSVFAHDLPEEPCLPKHQQYNGVIRT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X75603
EMBL· GenBank· DDBJ
CAA53271.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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