Q91225 · Q91225_ORENI

Function

function

Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

Catalytic activity

Features

Showing features for site, binding site.

1895100200300400500600700800
Type
IDPosition(s)Description
Site478Interaction with the cone snail toxin Con-ikot-ikot
Binding site503L-glutamate (UniProtKB | ChEBI)
Binding site505L-glutamate (UniProtKB | ChEBI)
Binding site510L-glutamate (UniProtKB | ChEBI)
Site658Crucial to convey clamshell closure to channel opening
Binding site679L-glutamate (UniProtKB | ChEBI)
Binding site680L-glutamate (UniProtKB | ChEBI)
Site685Interaction with the cone snail toxin Con-ikot-ikot
Binding site730L-glutamate (UniProtKB | ChEBI)
Site777Interaction with the cone snail toxin Con-ikot-ikot

GO annotations

AspectTerm
Cellular ComponentAMPA glutamate receptor complex
Cellular Componentdendritic spine
Cellular Componentpostsynaptic density membrane
Molecular FunctionAMPA glutamate receptor activity
Molecular Functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Processmodulation of chemical synaptic transmission
Biological Processsynaptic transmission, glutamatergic

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Glutamate receptor

Gene names

    • Name
      fGluR2A

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Cichlomorphae > Cichliformes > Cichlidae > African cichlids > Pseudocrenilabrinae > Oreochromini > Oreochromis

Accessions

  • Primary accession
    Q91225

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Postsynaptic cell membrane
Postsynaptic density membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane548-568Helical
Transmembrane629-651Helical
Transmembrane819-841Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-28
ChainPRO_502713334329-895Glutamate receptor
Disulfide bond84↔335
Disulfide bond743↔798

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain419-794Ionotropic glutamate receptor C-terminal
Domain429-494Ionotropic glutamate receptor L-glutamate and glycine-binding

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    895
  • Mass (Da)
    100,564
  • Last updated
    1996-11-01 v1
  • MD5 Checksum
    76B02D4C09A0EBE2987608DFCCA14B75
MLWCCARILNTTMKLLFLVALLWRGALCGSPSVQIGGLFPRGADQEYSAFRVGMVQFGMADFRLTPHIDNLEVANSFAVTNCFCSQFSRGVYAIFGFYDKKSVNTITSFCETLHVSFITPSFPAEGMNQFVLQMRPDIKGALVSLVEYYKWEKFAYLYDSDRGLSTLQVILDTAAEKKWVVTAINVGNLKDERKDEAYRSLFQDLEIRKERRIILDCEQDKVKDIMEQVITIGRHVKGYHYIIANLGFVDGDLSKIQYGGANVSGFQIVDFDDPVVAKFDQRWEALEEKEYPGADTRIRYPSALTYNAVHVMTEAFRFLHKQRTDISRRGNSGDCLANPAVPWATGVEIERALKQVHVDGLTGNIQFDQYGKRINYSVTIMELKNNGPVKIGYWNEVDKMVLTKSDLYPNDTMGMENKTVIVTTILEAPYVMLKKNAELFQDNDRYEGYCVDLAAEIAKHCGIRYQLRIVGDGKYGARDAETKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPQAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWTLEEPEDGALPLTTESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIALFDKMWQYMKNAEPSVFVKKTSEGVQRVRKCKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSPLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGESKEKTSALSLSNVAGVFYILVGGLGLAMMVALVEFCYKSRAEAKKMKMKFTDAMRSKARLSITGSTSENGRVPVAYLRPGLPMSLSMSDLS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L34080
EMBL· GenBank· DDBJ
AAB37744.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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