Q91225 · Q91225_ORENI
- ProteinGlutamate receptor
- GenefGluR2A
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids895 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Catalytic activity
- Ca2+(in) = Ca2+(out)
- Na+(in) = Na+(out)
Features
Showing features for site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 478 | Interaction with the cone snail toxin Con-ikot-ikot | |||
Binding site | 503 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 505 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 510 | L-glutamate (UniProtKB | ChEBI) | |||
Site | 658 | Crucial to convey clamshell closure to channel opening | |||
Binding site | 679 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 680 | L-glutamate (UniProtKB | ChEBI) | |||
Site | 685 | Interaction with the cone snail toxin Con-ikot-ikot | |||
Binding site | 730 | L-glutamate (UniProtKB | ChEBI) | |||
Site | 777 | Interaction with the cone snail toxin Con-ikot-ikot | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | AMPA glutamate receptor complex | |
Cellular Component | dendritic spine | |
Cellular Component | postsynaptic density membrane | |
Molecular Function | AMPA glutamate receptor activity | |
Molecular Function | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | |
Biological Process | modulation of chemical synaptic transmission | |
Biological Process | synaptic transmission, glutamatergic |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameGlutamate receptor
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Cichlomorphae > Cichliformes > Cichlidae > African cichlids > Pseudocrenilabrinae > Oreochromini > Oreochromis
Accessions
- Primary accessionQ91225
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Postsynaptic density membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 548-568 | Helical | |||
Transmembrane | 629-651 | Helical | |||
Transmembrane | 819-841 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-28 | ||||
Chain | PRO_5027133343 | 29-895 | Glutamate receptor | ||
Disulfide bond | 84↔335 | ||||
Disulfide bond | 743↔798 | ||||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 419-794 | Ionotropic glutamate receptor C-terminal | |||
Domain | 429-494 | Ionotropic glutamate receptor L-glutamate and glycine-binding | |||
Sequence similarities
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length895
- Mass (Da)100,564
- Last updated1996-11-01 v1
- MD5 Checksum76B02D4C09A0EBE2987608DFCCA14B75
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L34080 EMBL· GenBank· DDBJ | AAB37744.1 EMBL· GenBank· DDBJ | mRNA |