Q90ZZ6 · NANO1_XENTR

Function

function

Acts as a translational repressor. Can mediate repression affecting different steps in the translation process: cap-driven, IRES-driven, polyadenylated RNAs or nonpolyadenylated RNAs. Essential for the development of primordial germ cells (PGCs) by ensuring their proper migration and survival (By similarity).

Features

Showing features for binding site.

1128102030405060708090100110120
TypeIDPosition(s)Description
Binding site61Zn2+ 1 (UniProtKB | ChEBI)
Binding site64Zn2+ 1 (UniProtKB | ChEBI)
Binding site77Zn2+ 1 (UniProtKB | ChEBI)
Binding site88Zn2+ 1 (UniProtKB | ChEBI)
Binding site96Zn2+ 2 (UniProtKB | ChEBI)
Binding site99Zn2+ 2 (UniProtKB | ChEBI)
Binding site107Zn2+ 2 (UniProtKB | ChEBI)
Binding site112Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentgerm plasm
Cellular Componentperinuclear region of cytoplasm
Molecular FunctionRNA binding
Molecular Functiontranslation repressor activity
Molecular Functionzinc ion binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nanos homolog 1
  • Alternative names
    • Xcat-2 protein

Gene names

    • Name
      nanos1
    • Synonyms
      xcat-2

Organism names

Accessions

  • Primary accession
    Q90ZZ6
  • Secondary accessions
    • B7ZTT7

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Note: During early cleavage and blastula stages found close to the cell periphery in a germ plasm-like pattern. From gastrula stage on, detected predominantly in a perinuclear region (By similarity).

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004109791-128Nanos homolog 1

Proteomic databases

Interaction

Subunit

Interacts with ccnb1.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, zinc finger, motif.

Type
IDPosition(s)Description
Region7-23Essential for its translational repressor activity
Region23-58Disordered
Zinc finger60-114Nanos-type
Motif61-88C2HC 1
Motif96-112C2HC 2

Domain

The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.

Sequence similarities

Belongs to the nanos family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    128
  • Mass (Da)
    14,140
  • Last updated
    2001-12-01 v1
  • Checksum
    E79556DEF1C0880B
MDGGLCFNSWSDYLGLSSLISRGLQPREGGESPRPRWKASSPTPAEPLPSKAAEAHGHKGCGFCRSNREAQSLYSSHRLRAPDGRVLCPVLRGYTCPLCGANGDWAHTMRYCPLRHFLRHPHSPRDGQ

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict41in Ref. 2; AAI70990

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF256086
EMBL· GenBank· DDBJ
AAK49295.1
EMBL· GenBank· DDBJ
mRNA
BC160384
EMBL· GenBank· DDBJ
AAI60384.1
EMBL· GenBank· DDBJ
mRNA
BC170990
EMBL· GenBank· DDBJ
AAI70990.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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