Q90WY4 · ADA2A_DANRE
- ProteinAlpha-2A adrenergic receptor
- Geneadra2a
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids388 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is dexmedetomidine > oxymetazoline = epinephrine > norepinephrine.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 102 | Implicated in ligand binding | ||||
Sequence: D | ||||||
Site | 181 | Implicated in catechol agonist binding and receptor activation | ||||
Sequence: S | ||||||
Site | 185 | Implicated in catechol agonist binding and receptor activation | ||||
Sequence: S |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | alpha2-adrenergic receptor activity | |
Molecular Function | epinephrine binding | |
Biological Process | adenylate cyclase-activating adrenergic receptor signaling pathway | |
Biological Process | adenylate cyclase-inhibiting adrenergic receptor signaling pathway | |
Biological Process | G protein-coupled receptor signaling pathway | |
Biological Process | positive regulation of MAPK cascade |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlpha-2A adrenergic receptor
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ90WY4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-22 | Extracellular | ||||
Sequence: MICGANATNGTNATKEYTLLVA | ||||||
Transmembrane | 23-48 | Helical; Name=1 | ||||
Sequence: LPLSIAVGLLILLIIFGNVLVIIAVF | ||||||
Topological domain | 49-59 | Cytoplasmic | ||||
Sequence: TSRALRAPQNL | ||||||
Transmembrane | 60-85 | Helical; Name=2 | ||||
Sequence: FLVSLASADILVATLVMPFSLANELM | ||||||
Topological domain | 86-95 | Extracellular | ||||
Sequence: GMWTFGGVWC | ||||||
Transmembrane | 96-118 | Helical; Name=3 | ||||
Sequence: EIYLALDVLFCTASITHLCAISL | ||||||
Topological domain | 119-138 | Cytoplasmic | ||||
Sequence: DRYWSITQAIEYNLKRTPQR | ||||||
Transmembrane | 139-162 | Helical; Name=4 | ||||
Sequence: IKRIIFIVWIIAAVISCPPLITMK | ||||||
Topological domain | 163-173 | Extracellular | ||||
Sequence: KSEGDICDINK | ||||||
Transmembrane | 174-198 | Helical; Name=5 | ||||
Sequence: EKWYIVSSCIGSFFLPCIIMVLVYI | ||||||
Topological domain | 199-311 | Cytoplasmic | ||||
Sequence: RIYQIAKKRTRAPPGDHRKNEVGKKENDPHEKLNGIQNAEPDDKDEINGVDMEESSSSDHKVSNPCSLKKKSSKGKTKLSQIKPGDGDKTEACQTTKASRWKGRQNREKRFTF | ||||||
Transmembrane | 312-337 | Helical; Name=6 | ||||
Sequence: VLAVVIGVFVICWFPFFFTYTFTAFC | ||||||
Topological domain | 338-344 | Extracellular | ||||
Sequence: DCCVPET | ||||||
Transmembrane | 345-368 | Helical; Name=7 | ||||
Sequence: LFKFFFWFGYCNSSLNPIIYTIFN | ||||||
Topological domain | 369-388 | Cytoplasmic | ||||
Sequence: NDFRRSFKKILCRRDKRRVV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, lipidation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000069084 | 1-388 | Alpha-2A adrenergic receptor | |||
Sequence: MICGANATNGTNATKEYTLLVALPLSIAVGLLILLIIFGNVLVIIAVFTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGMWTFGGVWCEIYLALDVLFCTASITHLCAISLDRYWSITQAIEYNLKRTPQRIKRIIFIVWIIAAVISCPPLITMKKSEGDICDINKEKWYIVSSCIGSFFLPCIIMVLVYIRIYQIAKKRTRAPPGDHRKNEVGKKENDPHEKLNGIQNAEPDDKDEINGVDMEESSSSDHKVSNPCSLKKKSSKGKTKLSQIKPGDGDKTEACQTTKASRWKGRQNREKRFTFVLAVVIGVFVICWFPFFFTYTFTAFCDCCVPETLFKFFFWFGYCNSSLNPIIYTIFNNDFRRSFKKILCRRDKRRVV | ||||||
Glycosylation | 6 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 9 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 12 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 95↔169 | |||||
Sequence: CEIYLALDVLFCTASITHLCAISLDRYWSITQAIEYNLKRTPQRIKRIIFIVWIIAAVISCPPLITMKKSEGDIC | ||||||
Lipidation | 380 | S-palmitoyl cysteine | ||||
Sequence: C |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 208-256 | Basic and acidic residues | ||||
Sequence: TRAPPGDHRKNEVGKKENDPHEKLNGIQNAEPDDKDEINGVDMEESSSS | ||||||
Region | 208-291 | Disordered | ||||
Sequence: TRAPPGDHRKNEVGKKENDPHEKLNGIQNAEPDDKDEINGVDMEESSSSDHKVSNPCSLKKKSSKGKTKLSQIKPGDGDKTEAC |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length388
- Mass (Da)43,997
- Last updated2001-12-01 v1
- Checksum431965A04E1986DD
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q1L8Y8 | Q1L8Y8_DANRE | adra2a | 388 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 208-256 | Basic and acidic residues | ||||
Sequence: TRAPPGDHRKNEVGKKENDPHEKLNGIQNAEPDDKDEINGVDMEESSSS |
Keywords
- Technical term