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Q90964 · FOXG1_CHICK

  • Protein
    Forkhead box protein G1
  • Gene
    FOXG1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes.

Features

Showing features for dna binding.

145150100150200250300350400450
TypeIDPosition(s)Description
DNA binding142-233Fork-head

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionsequence-specific double-stranded DNA binding
Biological Processaxon midline choice point recognition
Biological Processdorsal/ventral pattern formation
Biological Processinner ear morphogenesis
Biological Processnegative regulation of neuron differentiation
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processneuroblast proliferation
Biological Processneuron fate determination
Biological Processpositive regulation of cell cycle
Biological Processpositive regulation of neuroblast proliferation
Biological Processpositive regulation of neuron differentiation
Biological Processpyramidal neuron migration to cerebral cortex
Biological Processregulation of mitotic cell cycle
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Forkhead box protein G1
  • Short names
    FoxG1
  • Alternative names
    • Brain factor 1 (BF-1; BF1; cBF-1)
    • CEQ 3-1
    • Forkhead-related protein FKHL1
    • N-62-5
    • Proto-oncogene C-QIN

Gene names

    • Name
      FOXG1
    • Synonyms
      FKHL1, FOXG1B, QIN

Organism names

  • Taxonomic identifier
  • Strain
    • White leghorn
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    Q90964

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 24 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000918391-451Forkhead box protein G1

Proteomic databases

Expression

Tissue specificity

Retina and brain.

Developmental stage

Can be detected in regions including primordial retina and neuroepithelium by embryonic day 2 (2dpc). At 3 dpc, expressed in the nasal retina and pigment epithelium as well as in the telencephalon, and at 7 dpc is expressed in retinal ganglion cells. Levels begin to decline from 4 dpc and almost disappear by 10 dpc.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region29-80Disordered
Compositional bias38-57Basic residues
Region101-143Disordered
Compositional bias104-142Basic and acidic residues
Region389-417Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    451
  • Mass (Da)
    48,857
  • Last updated
    1996-11-01 v1
  • MD5 Checksum
    8BC92558434C5AEE590C59ED48E6163C
MLDMGDRKEVKMLPKSSFSINSLVPEAVQSDNHSGHSHHNSHHPHHHHHHHHHHPPPPQQPQRAAAAEEEDEEKAPLLLPPPAAGALEAAKAEALAGKGEAGAAAAELEEKEKAAEEKKGAAEGGKDGESGKEGEKKNGKYEKPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRSTTSRAKLAFKRGARLTSTGLTFMDRAGSLYWPMSPFLSLHHPRASSTLSYNGTASAYPSHPMPYSSVLTQNSLGNNHSFSTSNGLSVDRLVNGEIPYATHHLTAAALAASVPCGLSVPCSGTYSLNPCSVNLLAGQTSYFFPHVPHPSMTSQSSTSMTARAASSSTSPQAPSTLPCESLRPSLPSFTTGLSGGLSDYFTHQNQGSSSNPLIH

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias38-57Basic residues
Compositional bias104-142Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L36814
EMBL· GenBank· DDBJ
AAA66954.1
EMBL· GenBank· DDBJ
mRNA
U47275
EMBL· GenBank· DDBJ
AAB08466.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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