Q90855 · Q90855_CHICK

  • Protein
    Glutamate receptor
  • Gene
    GluR1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

Features

Showing features for site, binding site.

1902100200300400500600700800900
Type
IDPosition(s)Description
Site467Interaction with the cone snail toxin Con-ikot-ikot
Binding site492L-glutamate (UniProtKB | ChEBI)
Binding site494L-glutamate (UniProtKB | ChEBI)
Binding site499L-glutamate (UniProtKB | ChEBI)
Site647Crucial to convey clamshell closure to channel opening
Binding site668L-glutamate (UniProtKB | ChEBI)
Binding site669L-glutamate (UniProtKB | ChEBI)
Site674Interaction with the cone snail toxin Con-ikot-ikot
Binding site719L-glutamate (UniProtKB | ChEBI)
Site766Interaction with the cone snail toxin Con-ikot-ikot

GO annotations

AspectTerm
Cellular ComponentAMPA glutamate receptor complex
Cellular Componentaxonal spine
Cellular Componentcell surface
Cellular Componentdendritic spine membrane
Cellular Componentendoplasmic reticulum
Cellular Componentexcitatory synapse
Cellular Componentglutamatergic synapse
Cellular Componentneuronal cell body
Cellular Componentperisynaptic space
Cellular Componentpostsynaptic density
Cellular Componentpostsynaptic density membrane
Cellular Componentrecycling endosome
Cellular Componentsynaptic membrane
Cellular Componentsynaptic vesicle membrane
Molecular FunctionAMPA glutamate receptor activity
Molecular Functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
Molecular Functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Processcellular response to ammonium ion
Biological Processconditioned taste aversion
Biological Processlong-term memory
Biological Processlong-term synaptic depression
Biological Processmemory
Biological Processreceptor internalization
Biological Processsynapse assembly

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Glutamate receptor

Gene names

    • Name
      GluR1
    • Synonyms
      A
      , GRIA1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Broiler
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    Q90855
  • Secondary accessions
    • F1NW92

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane535-557Helical
Transmembrane618-640Helical
Transmembrane808-830Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-18
ChainPRO_501431241819-902Glutamate receptor
Disulfide bond75↔323
Disulfide bond732↔787

Keywords

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain408-783Ionotropic glutamate receptor C-terminal
Domain418-483Ionotropic glutamate receptor L-glutamate and glycine-binding

Sequence similarities

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    902
  • Mass (Da)
    101,689
  • Last updated
    1996-11-01 v1
  • Checksum
    D1487E544D8B4CB4
MQHIFAFFCTSFLGVVLGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEMTYTFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVETSNQFVLQLRPELQDALISVIEHYSWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEGYRVLFQELQKKKERLVVVDCESERLNIILSKIIKLEKNGNGYHYILANMGFMDIDLTKFRESGANVTGFQLVNYTDTVPARIMQQWRNNDARELPRVDWKRPKYTSALTYDGVRVMAEAFQNLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLSGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDEKLVPVAIDTQTGNESTSLQNRTYIVTTILEDPYVMLKKNANQFEGNERYEGYCVELAAEIAKHVGYHYRLEIVRDGKYGARDPDTKTWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEEGRDQPANDQTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSINEAIRTSTLPRPAAAGGSGENGRVVSHDFPKSMQTIPCMSHSTGMSLGATGL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1D5PIW7A0A1D5PIW7_CHICKGRIA1902

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X89510
EMBL· GenBank· DDBJ
CAA61681.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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