Q90687 · PTN11_CHICK

  • Protein
    Tyrosine-protein phosphatase non-receptor type 11
  • Gene
    PTPN11
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation (By similarity).
The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (By similarity).
May play a positive role during the stages of erythroid cell proliferation (PubMed:8921851).

Catalytic activity

Features

Showing features for binding site, active site.

159350100150200250300350400450500550
TypeIDPosition(s)Description
Binding site425substrate
Active site459Phosphocysteine intermediate
Binding site459-465substrate
Binding site506substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functioncell adhesion molecule binding
Molecular Functionnon-membrane spanning protein tyrosine phosphatase activity
Molecular Functionprotein tyrosine phosphatase activity
Molecular Functionreceptor tyrosine kinase binding
Biological Processcellular response to epidermal growth factor stimulus
Biological Processnegative regulation of chondrocyte differentiation
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of ossification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein phosphatase non-receptor type 11
  • EC number
  • Alternative names
    • SH-PTP2 (cSH-PTP2)

Gene names

    • Name
      PTPN11

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    Q90687

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000947701-593Tyrosine-protein phosphatase non-receptor type 11

Post-translational modification

Phosphorylated by tyrosine-protein kinases.

Keywords

Proteomic databases

Expression

Tissue specificity

Expressed in embryonic fibroblast, hematopoietic, erythroid, myeloid and lymphoid cells.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain6-102SH2 1
Domain112-216SH2 2
Domain247-521Tyrosine-protein phosphatase
Region548-575Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    593
  • Mass (Da)
    67,983
  • Last updated
    1996-11-01 v1
  • Checksum
    415231144BB43DDA
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRTGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGREAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIHCQDLKYDVGGGEKFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYSLKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESISDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLSDQTSGDQSPLPPCTPTPTCPEMREDSARVYENVGLMQQQKSFR

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8V0ZFN3A0A8V0ZFN3_CHICKPTPN11593
A0A8V0ZEA4A0A8V0ZEA4_CHICKPTPN11590

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U38620
EMBL· GenBank· DDBJ
AAC60049.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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