Q90687 · PTN11_CHICK
- ProteinTyrosine-protein phosphatase non-receptor type 11
- GenePTPN11
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids593 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation (By similarity).
The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (By similarity).
May play a positive role during the stages of erythroid cell proliferation (PubMed:8921851).
The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (By similarity).
May play a positive role during the stages of erythroid cell proliferation (PubMed:8921851).
Catalytic activity
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 425 | substrate | ||||
Sequence: D | ||||||
Active site | 459 | Phosphocysteine intermediate | ||||
Sequence: C | ||||||
Binding site | 459-465 | substrate | ||||
Sequence: CSAGIGR | ||||||
Binding site | 506 | substrate | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | cell adhesion molecule binding | |
Molecular Function | non-membrane spanning protein tyrosine phosphatase activity | |
Molecular Function | protein tyrosine phosphatase activity | |
Molecular Function | receptor tyrosine kinase binding | |
Biological Process | cellular response to epidermal growth factor stimulus | |
Biological Process | negative regulation of chondrocyte differentiation | |
Biological Process | positive regulation of ERK1 and ERK2 cascade | |
Biological Process | positive regulation of ossification |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein phosphatase non-receptor type 11
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionQ90687
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000094770 | 1-593 | Tyrosine-protein phosphatase non-receptor type 11 | |||
Sequence: MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRTGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGREAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIHCQDLKYDVGGGEKFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYSLKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESISDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLSDQTSGDQSPLPPCTPTPTCPEMREDSARVYENVGLMQQQKSFR |
Post-translational modification
Phosphorylated by tyrosine-protein kinases.
Keywords
- PTM
Proteomic databases
Expression
Tissue specificity
Expressed in embryonic fibroblast, hematopoietic, erythroid, myeloid and lymphoid cells.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-102 | SH2 1 | ||||
Sequence: WFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRTGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL | ||||||
Domain | 112-216 | SH2 2 | ||||
Sequence: WFHGHLSGREAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIHCQDLKYDVGGGEKFDSLTDLVEHYKKNPMVETLGTVLQLKQPL | ||||||
Domain | 247-521 | Tyrosine-protein phosphatase | ||||
Sequence: FWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYSLKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESISDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHY | ||||||
Region | 548-575 | Disordered | ||||
Sequence: SLSDQTSGDQSPLPPCTPTPTCPEMRED |
Sequence similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length593
- Mass (Da)67,983
- Last updated1996-11-01 v1
- Checksum415231144BB43DDA
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8V0ZFN3 | A0A8V0ZFN3_CHICK | PTPN11 | 593 | ||
A0A8V0ZEA4 | A0A8V0ZEA4_CHICK | PTPN11 | 590 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U38620 EMBL· GenBank· DDBJ | AAC60049.1 EMBL· GenBank· DDBJ | mRNA |