Q90678 · PAFA_CHICK

  • Protein
    Platelet-activating factor acetylhydrolase
  • Gene
    PLA2G7
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

Catalytic activity

Features

Showing features for active site.

142250100150200250300350400
TypeIDPosition(s)Description
Active site266Nucleophile
Active site289Charge relay system
Active site345Charge relay system

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Function1-alkyl-2-acetylglycerophosphocholine esterase activity
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Platelet-activating factor acetylhydrolase
  • EC number
  • Short names
    PAF acetylhydrolase
  • Alternative names
    • 1-alkyl-2-acetylglycerophosphocholine esterase
    • 2-acetyl-1-alkylglycerophosphocholine esterase
    • LDL-associated phospholipase A2 (LDL-PLA(2))
    • PAF 2-acylhydrolase

Gene names

    • Name
      PLA2G7

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    Q90678

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_000001783522-422Platelet-activating factor acetylhydrolase
Glycosylation331N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Plasma.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    422
  • Mass (Da)
    47,046
  • Last updated
    1997-11-01 v1
  • Checksum
    15A5C794376E9141
MASLWVRARRVFMKSRASGFSAKAATEMGSGGAEKGYRIPAGKGPHAVGCTDLMTGDAAEGSFLRLYYLSCDDTDTEETPWIPDKEYYQGLSDFLNVYRALGERLFQYYVGSVTCPAKSNAAFKPGEKYPLLVFSHGLGAFRTIYSAICIEMASQGFLVAAVEHRDESASATYFCKKKADSEPEEDQTSGVEKEWIYYRKLRAGEEERCLRHKQVQQRAQECIKALNLILKISSGEEVMNVLNSDFDWNHLKDSVDTSRIAVMGHSFGGATVIESLSKEIRFRCGIALDAWMLPVGDDTYQSSVQQPLLFINSEKFQWAANILKMKKLSSNDTNKKMITIKGSVHQSFPDFTFVSGEIIGKFFKLKGEIDPNEAIDICNHASLAFLQKHLSLKRDFDKWDSLVDGIGPNVISGTNIDLSPTE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U34278
EMBL· GenBank· DDBJ
AAC59717.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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