Q90678 · PAFA_CHICK
- ProteinPlatelet-activating factor acetylhydrolase
- GenePLA2G7
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids422 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
Catalytic activity
- a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H+
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 266 | Nucleophile | ||||
Sequence: S | ||||||
Active site | 289 | Charge relay system | ||||
Sequence: D | ||||||
Active site | 345 | Charge relay system | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | 1-alkyl-2-acetylglycerophosphocholine esterase activity | |
Biological Process | lipid catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended namePlatelet-activating factor acetylhydrolase
- EC number
- Short namesPAF acetylhydrolase
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionQ90678
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MASLWVRARRVFMKSRASGFS | ||||||
Chain | PRO_0000017835 | 22-422 | Platelet-activating factor acetylhydrolase | |||
Sequence: AKAATEMGSGGAEKGYRIPAGKGPHAVGCTDLMTGDAAEGSFLRLYYLSCDDTDTEETPWIPDKEYYQGLSDFLNVYRALGERLFQYYVGSVTCPAKSNAAFKPGEKYPLLVFSHGLGAFRTIYSAICIEMASQGFLVAAVEHRDESASATYFCKKKADSEPEEDQTSGVEKEWIYYRKLRAGEEERCLRHKQVQQRAQECIKALNLILKISSGEEVMNVLNSDFDWNHLKDSVDTSRIAVMGHSFGGATVIESLSKEIRFRCGIALDAWMLPVGDDTYQSSVQQPLLFINSEKFQWAANILKMKKLSSNDTNKKMITIKGSVHQSFPDFTFVSGEIIGKFFKLKGEIDPNEAIDICNHASLAFLQKHLSLKRDFDKWDSLVDGIGPNVISGTNIDLSPTE | ||||||
Glycosylation | 331 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Plasma.
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the AB hydrolase superfamily. Lipase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length422
- Mass (Da)47,046
- Last updated1997-11-01 v1
- Checksum15A5C794376E9141
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U34278 EMBL· GenBank· DDBJ | AAC59717.1 EMBL· GenBank· DDBJ | mRNA |