Q90617 · LAMP2_CHICK

  • Protein
    Lysosome-associated membrane glycoprotein 2
  • Gene
    LAMP2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy. Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. In the chaperone-mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2 (By similarity).
Plays a role in lysosomal protein degradation in response to starvation (By similarity).
Required for the fusion of autophagosomes with lysosomes during autophagy (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentautophagosome membrane
Cellular Componentlate endosome membrane
Cellular Componentlysosomal membrane
Cellular Componentlysosome
Cellular Componentplasma membrane
Molecular Functionion channel inhibitor activity
Biological Processautophagosome maturation
Biological Processcellular response to starvation
Biological Processchaperone-mediated autophagy
Biological Processlysosomal lumen acidification
Biological Processlysosomal protein catabolic process
Biological Processprotein targeting
Biological Processprotein targeting to lysosome involved in chaperone-mediated autophagy

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosome-associated membrane glycoprotein 2
  • Short names
    LAMP-2; Lysosome-associated membrane protein 2

Gene names

    • Name
      LAMP2

Organism names

  • Taxonomic identifier
  • Strain
    • White leghorn
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    Q90617
  • Secondary accessions
    • Q90616
    • Q90618

Proteomes

Organism-specific databases

Subcellular Location

Lysosome membrane
; Single-pass type I membrane protein
Endosome membrane
; Single-pass type I membrane protein
Cell membrane
; Single-pass type I membrane protein
Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain28-389Lumenal
Transmembrane390-414Helical
Topological domain415-425Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-27
ChainPRO_000001711428-425Lysosome-associated membrane glycoprotein 2
Glycosylation37N-linked (GlcNAc...) asparagine
Disulfide bond40↔78
Glycosylation56N-linked (GlcNAc...) asparagine
Glycosylation62N-linked (GlcNAc...) asparagine
Glycosylation74N-linked (GlcNAc...) asparagine
Glycosylation100N-linked (GlcNAc...) asparagine
Glycosylation105N-linked (GlcNAc...) asparagine
Glycosylation120N-linked (GlcNAc...) asparagine
Disulfide bond153↔189
Glycosylation163N-linked (GlcNAc...) asparagine
Glycosylation170N-linked (GlcNAc...) asparagine
Glycosylation179N-linked (GlcNAc...) asparagine
Glycosylation206N-linked (GlcNAc...) asparagine
Glycosylation232N-linked (GlcNAc...) asparagine
Glycosylation239N-linked (GlcNAc...) asparagine
Disulfide bond242↔274
Glycosylation252N-linked (GlcNAc...) asparagine
Glycosylation276N-linked (GlcNAc...) asparagine
Glycosylation287N-linked (GlcNAc...) asparagine
Glycosylation298N-linked (GlcNAc...) asparagine
Glycosylation312N-linked (GlcNAc...) asparagine
Glycosylation320N-linked (GlcNAc...) asparagine
Glycosylation331N-linked (GlcNAc...) asparagine
Disulfide bond345↔382

Post-translational modification

Extensively N-glycosylated. Contains a minor proportion of O-linked glycans.

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Monomer. Forms large homooligomers.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region28-192First lumenal domain
Region193-238Hinge
Region239-390Second lumenal domain
Region416-419Important for binding and subsequent lysosomal degradation of target proteins

Sequence similarities

Belongs to the LAMP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 3 isoforms produced by Alternative splicing.

Q90617-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    LAMP-2B
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    425
  • Mass (Da)
    46,715
  • Last updated
    1996-11-01 v1
  • Checksum
    AC16730A98FDB359
MAPPRCPAGLALLLLLLGACGFFQSYAVEVDVKDASNFTCLYAQWMMKFLIKYETNSSDYKNASLDLTSTVTHNGSICGSDTQAALLAVQFGDGHSWSINFTKNNETYRAEFITFTYNTNDTAVFPDARRQGPVTIVVKDAMHPIQLNNVFVCHHTTSLEAENVTQIFWNVTMQPFVQNGTISKKESRCYADTPTAAPTVLPTVANVTTASTTISPAPTTAPKPAENPVTGNYSLKTGNKTCLLATVGLQLNISQDKPLLINIDPKTTHADGTCGNTSATLKLNDGNRTLIDFTFIVNASASVQKFYLREVNVTLLNYQNGSVILSADNNNLSKWDASLGNSYMCRKEQTLEINENLQVHTFNLWVQPFLVKENKFSIAEECFADSDLNFLIPVAVGMALGFLIILVFISYIIGRRKSRTGYQSV

Q90617-2

  • Name
    LAMP-2A
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 381-425: ECFADSDLNFLIPVAVGMALGFLIILVFISYIIGRRKSRTGYQSV → DCSPEVDYFIVPIAVGAALGGLVVLVIMAYFLGHKKHHNTGYEQF

Q90617-3

  • Name
    LAMP-2C
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 380-425: EECFADSDLNFLIPVAVGMALGFLIILVFISYIIGRRKSRTGYQSV → QECSLDDDTILIPIVVGAALAGLIVIIVIAYIIGRRKSYAGYQTL

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict261in Ref. 1; AAA99539/AAA99541
Sequence conflict277in Ref. 1; AAA99539/AAA99541
Alternative sequenceVSP_003047380-425in isoform LAMP-2C
Alternative sequenceVSP_003048381-425in isoform LAMP-2A

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U10547
EMBL· GenBank· DDBJ
AAA99540.1
EMBL· GenBank· DDBJ
mRNA
U10546
EMBL· GenBank· DDBJ
AAA99539.1
EMBL· GenBank· DDBJ
mRNA
U10548
EMBL· GenBank· DDBJ
AAA99541.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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