Q90617 · LAMP2_CHICK
- ProteinLysosome-associated membrane glycoprotein 2
- GeneLAMP2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids425 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy. Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. In the chaperone-mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2 (By similarity).
Plays a role in lysosomal protein degradation in response to starvation (By similarity).
Required for the fusion of autophagosomes with lysosomes during autophagy (By similarity).
Plays a role in lysosomal protein degradation in response to starvation (By similarity).
Required for the fusion of autophagosomes with lysosomes during autophagy (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | autophagosome membrane | |
Cellular Component | late endosome membrane | |
Cellular Component | lysosomal membrane | |
Cellular Component | lysosome | |
Cellular Component | plasma membrane | |
Molecular Function | ion channel inhibitor activity | |
Biological Process | autophagosome maturation | |
Biological Process | cellular response to starvation | |
Biological Process | chaperone-mediated autophagy | |
Biological Process | lysosomal lumen acidification | |
Biological Process | lysosomal protein catabolic process | |
Biological Process | protein targeting | |
Biological Process | protein targeting to lysosome involved in chaperone-mediated autophagy |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameLysosome-associated membrane glycoprotein 2
- Short namesLAMP-2; Lysosome-associated membrane protein 2
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionQ90617
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Lysosome membrane ; Single-pass type I membrane protein
Endosome membrane ; Single-pass type I membrane protein
Cell membrane ; Single-pass type I membrane protein
Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 28-389 | Lumenal | ||||
Sequence: VEVDVKDASNFTCLYAQWMMKFLIKYETNSSDYKNASLDLTSTVTHNGSICGSDTQAALLAVQFGDGHSWSINFTKNNETYRAEFITFTYNTNDTAVFPDARRQGPVTIVVKDAMHPIQLNNVFVCHHTTSLEAENVTQIFWNVTMQPFVQNGTISKKESRCYADTPTAAPTVLPTVANVTTASTTISPAPTTAPKPAENPVTGNYSLKTGNKTCLLATVGLQLNISQDKPLLINIDPKTTHADGTCGNTSATLKLNDGNRTLIDFTFIVNASASVQKFYLREVNVTLLNYQNGSVILSADNNNLSKWDASLGNSYMCRKEQTLEINENLQVHTFNLWVQPFLVKENKFSIAEECFADSDLN | ||||||
Transmembrane | 390-414 | Helical | ||||
Sequence: FLIPVAVGMALGFLIILVFISYIIG | ||||||
Topological domain | 415-425 | Cytoplasmic | ||||
Sequence: RRKSRTGYQSV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-27 | |||||
Sequence: MAPPRCPAGLALLLLLLGACGFFQSYA | ||||||
Chain | PRO_0000017114 | 28-425 | Lysosome-associated membrane glycoprotein 2 | |||
Sequence: VEVDVKDASNFTCLYAQWMMKFLIKYETNSSDYKNASLDLTSTVTHNGSICGSDTQAALLAVQFGDGHSWSINFTKNNETYRAEFITFTYNTNDTAVFPDARRQGPVTIVVKDAMHPIQLNNVFVCHHTTSLEAENVTQIFWNVTMQPFVQNGTISKKESRCYADTPTAAPTVLPTVANVTTASTTISPAPTTAPKPAENPVTGNYSLKTGNKTCLLATVGLQLNISQDKPLLINIDPKTTHADGTCGNTSATLKLNDGNRTLIDFTFIVNASASVQKFYLREVNVTLLNYQNGSVILSADNNNLSKWDASLGNSYMCRKEQTLEINENLQVHTFNLWVQPFLVKENKFSIAEECFADSDLNFLIPVAVGMALGFLIILVFISYIIGRRKSRTGYQSV | ||||||
Glycosylation | 37 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 40↔78 | |||||
Sequence: CLYAQWMMKFLIKYETNSSDYKNASLDLTSTVTHNGSIC | ||||||
Glycosylation | 56 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 62 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 74 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 100 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 105 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 120 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 153↔189 | |||||
Sequence: CHHTTSLEAENVTQIFWNVTMQPFVQNGTISKKESRC | ||||||
Glycosylation | 163 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 170 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 179 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 206 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 232 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 239 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 242↔274 | |||||
Sequence: CLLATVGLQLNISQDKPLLINIDPKTTHADGTC | ||||||
Glycosylation | 252 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 276 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 287 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 298 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 312 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 320 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 331 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 345↔382 | |||||
Sequence: CRKEQTLEINENLQVHTFNLWVQPFLVKENKFSIAEEC |
Post-translational modification
Extensively N-glycosylated. Contains a minor proportion of O-linked glycans.
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 28-192 | First lumenal domain | ||||
Sequence: VEVDVKDASNFTCLYAQWMMKFLIKYETNSSDYKNASLDLTSTVTHNGSICGSDTQAALLAVQFGDGHSWSINFTKNNETYRAEFITFTYNTNDTAVFPDARRQGPVTIVVKDAMHPIQLNNVFVCHHTTSLEAENVTQIFWNVTMQPFVQNGTISKKESRCYAD | ||||||
Region | 193-238 | Hinge | ||||
Sequence: TPTAAPTVLPTVANVTTASTTISPAPTTAPKPAENPVTGNYSLKTG | ||||||
Region | 239-390 | Second lumenal domain | ||||
Sequence: NKTCLLATVGLQLNISQDKPLLINIDPKTTHADGTCGNTSATLKLNDGNRTLIDFTFIVNASASVQKFYLREVNVTLLNYQNGSVILSADNNNLSKWDASLGNSYMCRKEQTLEINENLQVHTFNLWVQPFLVKENKFSIAEECFADSDLNF | ||||||
Region | 416-419 | Important for binding and subsequent lysosomal degradation of target proteins | ||||
Sequence: RKSR |
Sequence similarities
Belongs to the LAMP family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 3 isoforms produced by Alternative splicing.
Q90617-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameLAMP-2B
- Length425
- Mass (Da)46,715
- Last updated1996-11-01 v1
- ChecksumAC16730A98FDB359
Q90617-2
- NameLAMP-2A
- Differences from canonical
- 381-425: ECFADSDLNFLIPVAVGMALGFLIILVFISYIIGRRKSRTGYQSV → DCSPEVDYFIVPIAVGAALGGLVVLVIMAYFLGHKKHHNTGYEQF
Q90617-3
- NameLAMP-2C
- Differences from canonical
- 380-425: EECFADSDLNFLIPVAVGMALGFLIILVFISYIIGRRKSRTGYQSV → QECSLDDDTILIPIVVGAALAGLIVIIVIAYIIGRRKSYAGYQTL
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 261 | in Ref. 1; AAA99539/AAA99541 | ||||
Sequence: I → L | ||||||
Sequence conflict | 277 | in Ref. 1; AAA99539/AAA99541 | ||||
Sequence: T → A | ||||||
Alternative sequence | VSP_003047 | 380-425 | in isoform LAMP-2C | |||
Sequence: EECFADSDLNFLIPVAVGMALGFLIILVFISYIIGRRKSRTGYQSV → QECSLDDDTILIPIVVGAALAGLIVIIVIAYIIGRRKSYAGYQTL | ||||||
Alternative sequence | VSP_003048 | 381-425 | in isoform LAMP-2A | |||
Sequence: ECFADSDLNFLIPVAVGMALGFLIILVFISYIIGRRKSRTGYQSV → DCSPEVDYFIVPIAVGAALGGLVVLVIMAYFLGHKKHHNTGYEQF |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U10547 EMBL· GenBank· DDBJ | AAA99540.1 EMBL· GenBank· DDBJ | mRNA | ||
U10546 EMBL· GenBank· DDBJ | AAA99539.1 EMBL· GenBank· DDBJ | mRNA | ||
U10548 EMBL· GenBank· DDBJ | AAA99541.1 EMBL· GenBank· DDBJ | mRNA |