Q90476 · LHX1_DANRE

Function

function

Seems to play a role in dorsal axis formation.

Features

Showing features for dna binding.

140550100150200250300350400
TypeIDPosition(s)Description
DNA binding179-238Homeobox

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Cellular Componentprotein-containing complex
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Functionzinc ion binding
Biological Processanatomical structure formation involved in morphogenesis
Biological Processanatomical structure morphogenesis
Biological Processanterior/posterior axis specification
Biological Processanterior/posterior pattern specification
Biological Processcell-cell signaling
Biological Processcerebellar Purkinje cell differentiation
Biological Processcerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
Biological Processcerebellum development
Biological Processcomma-shaped body morphogenesis
Biological Processdorsal spinal cord interneuron posterior axon guidance
Biological Processdorsal/ventral pattern formation
Biological Processectoderm formation
Biological Processembryonic pattern specification
Biological Processembryonic retina morphogenesis in camera-type eye
Biological Processendoderm formation
Biological Processepithelium development
Biological Processforebrain regionalization
Biological Processgastrulation with mouth forming second
Biological Processhead development
Biological Processkidney development
Biological Processlateral motor column neuron migration
Biological Processmotor neuron axon guidance
Biological Processnegative regulation of DNA-templated transcription
Biological Processnephric duct morphogenesis
Biological Processneuron differentiation
Biological Processparamesonephric duct development
Biological Processpattern specification process
Biological Processpositive regulation of anterior head development
Biological Processpositive regulation of branching involved in ureteric bud morphogenesis
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of embryonic development
Biological Processpositive regulation of gastrulation
Biological Processpositive regulation of nephron tubule epithelial cell differentiation
Biological Processpost-embryonic development
Biological Processprimitive streak formation
Biological Processregulation of gene expression
Biological Processregulation of transcription by RNA polymerase II
Biological Processrenal vesicle morphogenesis
Biological Processretina layer formation
Biological ProcessS-shaped body morphogenesis
Biological Processspinal cord association neuron differentiation
Biological Processtranscription by RNA polymerase II
Biological Processureteric bud development
Biological Processurogenital system development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    LIM/homeobox protein Lhx1
  • Short names
    LIM homeobox protein 1
  • Alternative names
    • Homeobox protein Lim-1

Gene names

    • Name
      lhx1a
    • Synonyms
      lhx1, lim1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q90476

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000757761-405LIM/homeobox protein Lhx1

Proteomic databases

Expression

Developmental stage

Detected 4 hours after fertilization with maximum levels seen in 6 hours embryos. Expression then declines during gastrulation (6-10 hours), but is still detectable in 24 and 30 hours embryos. The spatial distribution also varies during embryogenesis: at the beginning, expression is localized in deep cells and is absent from the enveloping layer. The pattern then becomes asymmetric, restricting to the forming embryonic shield. By the shield stage, it is highly localized in the axial hypoblast. As gastrulation proceeds, expression continues in the involuting cells, extending from the margin towards the anterior.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain4-54LIM zinc-binding 1
Domain63-117LIM zinc-binding 2
Compositional bias158-178Basic and acidic residues
Region158-184Disordered
Compositional bias296-312Polar residues
Region296-373Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    405
  • Mass (Da)
    45,154
  • Last updated
    1996-11-01 v1
  • Checksum
    186EEBEB59C88123
MVHCAGCERPILDRFLLNVLDRAWHIKCVQCCECKCNLTEKCFSREGKLYCKNDFFRRFGTKCAGCAQGISPNDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKDDYLSNTNGKDSNLLSVTACSDPSLSPDSQDQLQDDVKDAEIANLSDKETGNNENDDQNLGGKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRTLVDRLEPGELIPNGPFSYYGDYQSEYYGPGGNYDFFPQGPPSSQAQTPVDLPFVPSSGPTGTPLGGMDHPIPGHHPSSEVQRFSDIMSHHPGDSPSPEPGIPGPLHSMSSDVFGPSPSFTSLSLNGSGYSNHLSHPPSEMNEGTVW

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias158-178Basic and acidic residues
Compositional bias296-312Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L37802
EMBL· GenBank· DDBJ
AAA92157.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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