Q90476 · LHX1_DANRE
- ProteinLIM/homeobox protein Lhx1
- Genelhx1a
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids405 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Seems to play a role in dorsal axis formation.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 179-238 | Homeobox | ||||
Sequence: RRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMK |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameLIM/homeobox protein Lhx1
- Short namesLIM homeobox protein 1
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ90476
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000075776 | 1-405 | LIM/homeobox protein Lhx1 | |||
Sequence: MVHCAGCERPILDRFLLNVLDRAWHIKCVQCCECKCNLTEKCFSREGKLYCKNDFFRRFGTKCAGCAQGISPNDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKDDYLSNTNGKDSNLLSVTACSDPSLSPDSQDQLQDDVKDAEIANLSDKETGNNENDDQNLGGKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRTLVDRLEPGELIPNGPFSYYGDYQSEYYGPGGNYDFFPQGPPSSQAQTPVDLPFVPSSGPTGTPLGGMDHPIPGHHPSSEVQRFSDIMSHHPGDSPSPEPGIPGPLHSMSSDVFGPSPSFTSLSLNGSGYSNHLSHPPSEMNEGTVW |
Proteomic databases
Expression
Developmental stage
Detected 4 hours after fertilization with maximum levels seen in 6 hours embryos. Expression then declines during gastrulation (6-10 hours), but is still detectable in 24 and 30 hours embryos. The spatial distribution also varies during embryogenesis: at the beginning, expression is localized in deep cells and is absent from the enveloping layer. The pattern then becomes asymmetric, restricting to the forming embryonic shield. By the shield stage, it is highly localized in the axial hypoblast. As gastrulation proceeds, expression continues in the involuting cells, extending from the margin towards the anterior.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-54 | LIM zinc-binding 1 | ||||
Sequence: CAGCERPILDRFLLNVLDRAWHIKCVQCCECKCNLTEKCFSREGKLYCKND | ||||||
Domain | 63-117 | LIM zinc-binding 2 | ||||
Sequence: CAGCAQGISPNDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKDD | ||||||
Compositional bias | 158-178 | Basic and acidic residues | ||||
Sequence: ANLSDKETGNNENDDQNLGGK | ||||||
Region | 158-184 | Disordered | ||||
Sequence: ANLSDKETGNNENDDQNLGGKRRGPRT | ||||||
Compositional bias | 296-312 | Polar residues | ||||
Sequence: PQGPPSSQAQTPVDLPF | ||||||
Region | 296-373 | Disordered | ||||
Sequence: PQGPPSSQAQTPVDLPFVPSSGPTGTPLGGMDHPIPGHHPSSEVQRFSDIMSHHPGDSPSPEPGIPGPLHSMSSDVFG |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length405
- Mass (Da)45,154
- Last updated1996-11-01 v1
- Checksum186EEBEB59C88123
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 158-178 | Basic and acidic residues | ||||
Sequence: ANLSDKETGNNENDDQNLGGK | ||||||
Compositional bias | 296-312 | Polar residues | ||||
Sequence: PQGPPSSQAQTPVDLPF |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L37802 EMBL· GenBank· DDBJ | AAA92157.1 EMBL· GenBank· DDBJ | mRNA |