Q8ZQN7 · DING_SALTY
- ProteinATP-dependent DNA helicase DinG
- GenedinG
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids714 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
DNA-dependent ATPase and 5'-3' DNA helicase. Unwinds D-loops, R-loops, forked DNA and G-quadruplex DNA.
Catalytic activity
- Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.
- ATP + H2O = ADP + H+ + phosphate
Cofactor
Note: Binds 1 [4Fe-4S] cluster.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 54-61 | ATP (UniProtKB | ChEBI) | ||||
Sequence: APTGVGKT | ||||||
Binding site | 120 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 194 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 199 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 205 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | DNA binding | |
Molecular Function | DNA helicase activity | |
Molecular Function | DNA/RNA helicase activity | |
Molecular Function | isomerase activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA duplex unwinding | |
Biological Process | DNA repair | |
Biological Process | SOS response |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent DNA helicase DinG
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionQ8ZQN7
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000102001 | 1-714 | ATP-dependent DNA helicase DinG | |||
Sequence: MALTAALKAQIAAWYKALQDQIPDFIPRAPQRQMIADVARTLAGEEGRHLAIEAPTGVGKTLSYLIPGIAIAREEQKTLVVSTANVALQDQIFSKDLPLLRKIIPDLRFTAAFGRGRYVCPRNLAALASSEPTQQDLLAFLDDELTPNNQEEQKRCARLKGDLDGYKWDGLRDHTDIAIDDDLWRRLSTDKASCLNRNCHYYRECPFFVARREIQEAEVVVANHALVMAAMESEAVLPEPKHLLLVLDEGHHLPDVARDALEMSAEITASWYRLQLDLFSKLVATCMEQFRPKTTPPLANPERLNAHCEEVYELIASLNAILNLYMPAAQEAEHRFAMGELPDEVMEICQRLAKLTETLRGLAESFLNDLSEKTGSHDIVRLHRVILQMNRALGMFEAQSKLWRLASMAQSSGAPVSKWATREIREGQLHVWFHCVGIRVSDQLERLLWRSVPHIIVTSATLRSLNSFSRLQEMSGLKEKAGDRFVALDSPFNHVEQGKLVIPQMRYEPTIDNEEQHIAEMAAYFREQLESKKHHGMLVLFASGRAMQRFLEHVADVRLLLLVQGDQPRYRLVELHRKRVESGERSVLVGLQSFAEGLDLKGELLTQVHIHKIAFPPIDSPVVITEGEWLKSLNRYPFEVQSLPSASFNLIQQVGRLIRSHACRGEVVIYDKRLLTKNYGQRLLNALPVFPIEQPAVPDVIVKPKAKPARRRRR |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 17-294 | Helicase ATP-binding | ||||
Sequence: ALQDQIPDFIPRAPQRQMIADVARTLAGEEGRHLAIEAPTGVGKTLSYLIPGIAIAREEQKTLVVSTANVALQDQIFSKDLPLLRKIIPDLRFTAAFGRGRYVCPRNLAALASSEPTQQDLLAFLDDELTPNNQEEQKRCARLKGDLDGYKWDGLRDHTDIAIDDDLWRRLSTDKASCLNRNCHYYRECPFFVARREIQEAEVVVANHALVMAAMESEAVLPEPKHLLLVLDEGHHLPDVARDALEMSAEITASWYRLQLDLFSKLVATCMEQFRPKT | ||||||
Motif | 248-251 | DEAH box | ||||
Sequence: DEGH | ||||||
Domain | 517-698 | Helicase C-terminal | ||||
Sequence: HIAEMAAYFREQLESKKHHGMLVLFASGRAMQRFLEHVADVRLLLLVQGDQPRYRLVELHRKRVESGERSVLVGLQSFAEGLDLKGELLTQVHIHKIAFPPIDSPVVITEGEWLKSLNRYPFEVQSLPSASFNLIQQVGRLIRSHACRGEVVIYDKRLLTKNYGQRLLNALPVFPIEQPAVP |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length714
- Mass (Da)80,979
- Last updated2002-03-01 v1
- ChecksumA4DFA8847073C57C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE006468 EMBL· GenBank· DDBJ | AAL19758.1 EMBL· GenBank· DDBJ | Genomic DNA |