Q8ZJP7 · PYRE_YERPE
- ProteinOrotate phosphoribosyltransferase
- GenepyrE
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids215 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Catalytic activity
- orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
Cofactor
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 26 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | ||||
Sequence: K | ||||||
Binding site | 34-35 | orotate (UniProtKB | ChEBI) | ||||
Sequence: FF | ||||||
Binding site | 72-73 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | ||||
Sequence: YK | ||||||
Binding site | 99 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners | ||||
Sequence: R | ||||||
Binding site | 100 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | ||||
Sequence: K | ||||||
Binding site | 103 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners | ||||
Sequence: K | ||||||
Binding site | 105 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners | ||||
Sequence: H | ||||||
Binding site | 124-132 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | ||||
Sequence: DDVITAGTA | ||||||
Binding site | 128 | orotate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 156 | orotate (UniProtKB | ChEBI) | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | magnesium ion binding | |
Molecular Function | orotate phosphoribosyltransferase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process | |
Biological Process | pyrimidine nucleotide biosynthetic process | |
Biological Process | pyrimidine ribonucleoside biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOrotate phosphoribosyltransferase
- EC number
- Short namesOPRT ; OPRTase
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Yersinia
Accessions
- Primary accessionQ8ZJP7
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000110774 | 1-215 | Orotate phosphoribosyltransferase | |||
Sequence: MKAYQREFIEFALNKQVLKFGEFTLKSGRISPYFFNAGLFNTGLDLAKLGRFYAAALMDCGVEFDLLFGPAYKGIPIATTTAVALAEHHERDVPYCFNRKEAKTHGEGGNLVGSPLQGRVMLVDDVITAGTAIRESMEIINAQGATLAGVMISLDRQERGRGEISAIQEVERDYHCKVIAIVTLNDVIRYLEDKPEMAEHLVAVRQYREQYGVTL |
Proteomic databases
Structure
Sequence
- Sequence statusComplete
- Length215
- Mass (Da)23,954
- Last updated2002-03-01 v1
- ChecksumFAD81854CA2EDF3D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL590842 EMBL· GenBank· DDBJ | CAL18735.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE009952 EMBL· GenBank· DDBJ | AAM83690.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE017042 EMBL· GenBank· DDBJ | AAS60327.1 EMBL· GenBank· DDBJ | Genomic DNA |