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Q8ZBY7 · GMHA_YERPE

  • Protein
    Phosphoheptose isomerase
  • Gene
    gmhA
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.
Bacterial outer membrane biogenesis; LPS core biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site52-54substrate
Binding site61Zn2+ (UniProtKB | ChEBI)
Binding site65substrate
Binding site65Zn2+ (UniProtKB | ChEBI)
Binding site93-94substrate
Binding site119-121substrate
Binding site124substrate
Binding site172substrate
Binding site172Zn2+ (UniProtKB | ChEBI)
Binding site180Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncarbohydrate derivative binding
Molecular FunctionD-sedoheptulose 7-phosphate isomerase activity
Molecular Functionzinc ion binding
Biological ProcessD-glycero-D-manno-heptose 7-phosphate biosynthetic process
Biological Processlipopolysaccharide core region biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoheptose isomerase
  • EC number
  • Alternative names
    • Sedoheptulose 7-phosphate isomerase

Gene names

    • Name
      gmhA
    • Synonyms
      lpcA
    • Ordered locus names
      YPO3243, y0947, YP_0689

Organism names

  • Taxonomic identifier
  • Strains
    • CO-92 / Biovar Orientalis
    • KIM10+ / Biovar Mediaevalis
    • 91001 / Biovar Mediaevalis
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Yersinia

Accessions

  • Primary accession
    Q8ZBY7
  • Secondary accessions
    • Q0WC43

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001365511-193Phosphoheptose isomerase

Proteomic databases

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain37-193SIS

Sequence similarities

Belongs to the SIS family. GmhA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    193
  • Mass (Da)
    20,987
  • Last updated
    2002-03-01 v1
  • MD5 Checksum
    AA57B0A792AE74DF1BA7EA2DBF6E2262
MYHDLIRSELNEAADTLANFLKDDSNIDAIQRAAILLADSFKAGGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAIAISDVSHLSCVSNDFGYDYVFSRYVEAVDREGDVLLGISTSGNSGNIIKAIEAARAKGMKVITLTGKDGGKMAGSADIEIRVPHFGYADRIQEIHIKVIHILIQLIEKEMVKA

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict109in Ref. 2 and 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL590842
EMBL· GenBank· DDBJ
CAL21837.1
EMBL· GenBank· DDBJ
Genomic DNA
AE009952
EMBL· GenBank· DDBJ
AAM84528.1
EMBL· GenBank· DDBJ
Genomic DNA
AE017042
EMBL· GenBank· DDBJ
AAS60955.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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