Q8ZBY7 · GMHA_YERPE
- ProteinPhosphoheptose isomerase
- GenegmhA
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids193 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
Miscellaneous
The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.
Catalytic activity
- 2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.
Bacterial outer membrane biogenesis; LPS core biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 52-54 | substrate | |||
Binding site | 61 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 65 | substrate | |||
Binding site | 65 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 93-94 | substrate | |||
Binding site | 119-121 | substrate | |||
Binding site | 124 | substrate | |||
Binding site | 172 | substrate | |||
Binding site | 172 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 180 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | carbohydrate derivative binding | |
Molecular Function | D-sedoheptulose 7-phosphate isomerase activity | |
Molecular Function | zinc ion binding | |
Biological Process | D-glycero-D-manno-heptose 7-phosphate biosynthetic process | |
Biological Process | lipopolysaccharide core region biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoheptose isomerase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Yersinia
Accessions
- Primary accessionQ8ZBY7
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000136551 | 1-193 | Phosphoheptose isomerase | ||
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length193
- Mass (Da)20,987
- Last updated2002-03-01 v1
- MD5 ChecksumAA57B0A792AE74DF1BA7EA2DBF6E2262
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 109 | in Ref. 2 and 3 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL590842 EMBL· GenBank· DDBJ | CAL21837.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE009952 EMBL· GenBank· DDBJ | AAM84528.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE017042 EMBL· GenBank· DDBJ | AAS60955.1 EMBL· GenBank· DDBJ | Genomic DNA |