Q8ZBK7 · PANC_YERPE
- ProteinPantothenate synthetase
- GenepanC
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids284 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Miscellaneous
The reaction proceeds by a bi uni uni bi ping pong mechanism.
Catalytic activity
- (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H+
Pathway
Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 30-37 | ATP (UniProtKB | ChEBI) | ||||
Sequence: MGNLHEGH | ||||||
Active site | 37 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 61 | (R)-pantoate (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 61 | beta-alanine (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 149-152 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GEKD | ||||||
Binding site | 155 | (R)-pantoate (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 178 | ATP (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 186-189 | ATP (UniProtKB | ChEBI) | ||||
Sequence: LSSR |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | pantoate-beta-alanine ligase activity | |
Biological Process | pantothenate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePantothenate synthetase
- EC number
- Short namesPS
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Yersinia
Accessions
- Primary accessionQ8ZBK7
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000128295 | 1-284 | Pantothenate synthetase | |||
Sequence: MLIIETLPLLRQQIRRWRQEGKRIALVPTMGNLHEGHMTLVDEAKTRADVVVVTIFVNPLQFERPDDLAHYPRTLQEDCEKLTRHGADLVFAPAAADIYPAGLEKQTYVDVPALSTILEGASRPGHFRGVSTIVSKLFNLIQPDVACFGEKDYQQLALIRKMVADMGYDINIVGVPTVRAKDGLALSSRNGYLTEEERQIAPQLSKIMWALAEKMALGERQIDALLEEAAAQLLRVGFTPDELFIRDAETLQPLTVDSQQAVILMAAWLGKARLIDNQLVDLRH |
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length284
- Mass (Da)31,772
- Last updated2002-03-01 v1
- Checksum6F589341B134FA7F
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL590842 EMBL· GenBank· DDBJ | CAL21991.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE009952 EMBL· GenBank· DDBJ | AAM84372.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE017042 EMBL· GenBank· DDBJ | AAS60558.1 EMBL· GenBank· DDBJ | Genomic DNA |