Q8ZAR7 · ACEK_YERPE

  • Protein
    Isocitrate dehydrogenase kinase/phosphatase
  • Gene
    aceK
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.

Catalytic activity

Features

Showing features for binding site, active site.

157550100150200250300350400450500550
Type
IDPosition(s)Description
Binding site315-321ATP (UniProtKB | ChEBI)
Binding site336ATP (UniProtKB | ChEBI)
Active site371

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function[isocitrate dehydrogenase (NADP+)] kinase activity
Molecular FunctionAMP binding
Molecular FunctionATP binding
Molecular Functionphosphoprotein phosphatase activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processglucose metabolic process
Biological Processglyoxylate cycle
Biological Processphosphorylation
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Isocitrate dehydrogenase kinase/phosphatase
  • EC number
  • Short names
    IDH kinase/phosphatase
    ; IDHK/P

Gene names

    • Name
      aceK
    • Ordered locus names
      YPO3724, y0018, YP_3086

Organism names

  • Taxonomic identifier
  • Strains
    • CO-92 / Biovar Orientalis
    • KIM10+ / Biovar Mediaevalis
    • 91001 / Biovar Mediaevalis
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Yersinia

Accessions

  • Primary accession
    Q8ZAR7
  • Secondary accessions
    • Q0WAT4

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000579121-575Isocitrate dehydrogenase kinase/phosphatase

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the AceK family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    575
  • Mass (Da)
    67,622
  • Last updated
    2002-03-01 v1
  • Checksum
    6D4F202AF6C584FA
MVAKLEQLIAQTILQGFDAQYGRFLEVTAGAQHRFEQADWHAVQQAMKKRIHLYDHHVGLVVEQLKYITDQRHFDVEFLARVKEIYTGLLPDYPRFEIAESFFNSVYCRLFKHRDLTPDKLFVFSSQPERRFREIPRPLARDFIPKGDLSGMLQMVLNDLSLRLHWENLSRDIDYIVMAIRQAFTDEQLASAHFQIANELFYRNKAAWLVGKLRLNGDIYPFLLPIHHNESGELFIDTCLTSKAEASIVFGFARSYFMVYVPLPAAMVEWLREILPGKSTAELYTAIGCQKHGKTESYREYLAFIHQSSEQFIIAPGVKGMVMLVFTLPSFDRVFKVIKDQFAPQKEVTQARVLECYQLVKEHDRVGRMADTQEYENFVIDKHRISPELLAELQHEVPEKLEDLGDKIVIKHLYMERRMTPLNLYMEQADDQQLKDAIEEYGNAIKQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTEVNFRDIPPPRYPEDEMASEPWYSVSPNDVFPEEFRHFLCSDRKVRHFFEEMHGDLFQASYWRGLQQRIRDGHVEDVFAYRRKQRFSQRALN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL590842
EMBL· GenBank· DDBJ
CAL22311.1
EMBL· GenBank· DDBJ
Genomic DNA
AE009952
EMBL· GenBank· DDBJ
AAM83613.1
EMBL· GenBank· DDBJ
Genomic DNA
AE017042
EMBL· GenBank· DDBJ
AAS63256.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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