Q8ZAR7 · ACEK_YERPE
- ProteinIsocitrate dehydrogenase kinase/phosphatase
- GeneaceK
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids575 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
Catalytic activity
- L-seryl-[isocitrate dehydrogenase] + ATP = O-phospho-L-seryl-[isocitrate dehydrogenase] + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 315-321 | ATP (UniProtKB | ChEBI) | |||
Binding site | 336 | ATP (UniProtKB | ChEBI) | |||
Active site | 371 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | [isocitrate dehydrogenase (NADP+)] kinase activity | |
Molecular Function | AMP binding | |
Molecular Function | ATP binding | |
Molecular Function | phosphoprotein phosphatase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | glucose metabolic process | |
Biological Process | glyoxylate cycle | |
Biological Process | phosphorylation | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameIsocitrate dehydrogenase kinase/phosphatase
- EC number
- Short namesIDH kinase/phosphatase ; IDHK/P
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Yersinia
Accessions
- Primary accessionQ8ZAR7
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000057912 | 1-575 | Isocitrate dehydrogenase kinase/phosphatase | ||
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length575
- Mass (Da)67,622
- Last updated2002-03-01 v1
- Checksum6D4F202AF6C584FA
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL590842 EMBL· GenBank· DDBJ | CAL22311.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE009952 EMBL· GenBank· DDBJ | AAM83613.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE017042 EMBL· GenBank· DDBJ | AAS63256.1 EMBL· GenBank· DDBJ | Genomic DNA |