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Q8ZAP9 · THIG_YERPE

  • Protein
    Thiazole synthase
  • Gene
    thiG
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H2S.

Catalytic activity

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

Features

Showing features for active site, binding site.

127120406080100120140160180200220240260
Type
IDPosition(s)Description
Active site95Schiff-base intermediate with DXP
Binding site1561-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site182-1831-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site204-2051-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionthiazole synthase activity
Biological Processthiamine diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thiazole synthase
  • EC number

Gene names

    • Name
      thiG
    • Ordered locus names
      YPO3742, y0488, YP_3106

Organism names

  • Taxonomic identifier
  • Strains
    • CO-92 / Biovar Orientalis
    • KIM10+ / Biovar Mediaevalis
    • 91001 / Biovar Mediaevalis
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Yersinia

Accessions

  • Primary accession
    Q8ZAP9
  • Secondary accessions
    • Q0WAR6
    • Q8D1H1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001628821-271Thiazole synthase

Proteomic databases

Interaction

Subunit

Homotetramer. Forms heterodimers with either ThiH or ThiS.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the ThiG family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    271
  • Mass (Da)
    28,873
  • Last updated
    2003-06-16 v2
  • MD5 Checksum
    125CE2E9F0BA625C7AABD43770EED9B5
MLKIADTTFTSRLFTGTGKFSSPELMLEALRASGSQLITMAMKRVDLQSGNDAILAPLRQLGVRLLPNTSGAKTAEEAIFAARLAREALNTHWVKLEVHPDVRYLLPDPIETLKAAEVLVKEGFVVLPYCGADPVLCKRLEEVGCAAVMPLGSPIGSNLGLRTRDFLQIIIEQSKVPVVVDAGIGAPSHALEALELGADAVLVNTAIAVAHSPVQMAHAFRLAVESGERARLAGLGASPFNPSQPDTLQLRATATSPLTGFLSQLEEQDHV

Sequence caution

The sequence AAM84077.1 differs from that shown. Reason: Erroneous initiation
The sequence AAS63276.1 differs from that shown. Reason: Erroneous initiation
The sequence CAL22329.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict98in Ref. 2 and 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL590842
EMBL· GenBank· DDBJ
CAL22329.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
AE009952
EMBL· GenBank· DDBJ
AAM84077.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
AE017042
EMBL· GenBank· DDBJ
AAS63276.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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