Q8YVR1 · PFKA2_NOSS1

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Subject to allosteric activation by ADP and other diphosphonucleosides, and inhibition by phosphoenolpyruvate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site12ATP (UniProtKB | ChEBI)
Binding site80-81ATP (UniProtKB | ChEBI)
Binding site107-110ATP (UniProtKB | ChEBI)
Binding site108Mg2+ (UniProtKB | ChEBI); catalytic
Site109Important for substrate specificity; cannot use PPi as phosphoryl donor
Binding site131-133substrate; ligand shared between dimeric partners; in other chain
Active site133Proton acceptor
Binding site168substrate; ligand shared between dimeric partners
Binding site175-177substrate; ligand shared between dimeric partners; in other chain
Binding site229substrate; ligand shared between dimeric partners; in other chain
Binding site272substrate; ligand shared between dimeric partners
Binding site278-281substrate; ligand shared between dimeric partners; in other chain

GO annotations

AspectTerm
Cellular Component6-phosphofructokinase complex
Molecular Function6-phosphofructokinase activity
Molecular FunctionAMP binding
Molecular FunctionATP binding
Molecular Functiondiphosphate-fructose-6-phosphate 1-phosphotransferase activity
Molecular Functionfructose-6-phosphate binding
Molecular Functionidentical protein binding
Molecular Functionmetal ion binding
Molecular Functionmonosaccharide binding
Biological Processcanonical glycolysis
Biological Processfructose 1,6-bisphosphate metabolic process
Biological Processfructose 6-phosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent 6-phosphofructokinase 2
  • EC number
  • Short names
    ATP-PFK 2
    ; Phosphofructokinase 2
  • Alternative names
    • Phosphohexokinase 2

Gene names

    • Name
      pfkA2
    • Ordered locus names
      alr1913

Organism names

Accessions

  • Primary accession
    Q8YVR1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001119301-357ATP-dependent 6-phosphofructokinase 2

Interaction

Subunit

Homodimer or homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    357
  • Mass (Da)
    38,007
  • Last updated
    2002-03-01 v1
  • Checksum
    40A6C3C266A6E5D0
MRKRIGILTSGGDCPGLNCVIRAVVSHATLTYDWEVLGIPYATQGLRERQAIALNMHGWDLRGIDPLLNMGGTILGTINKGDTLAHVDEMLASYQALALDALIVIGGDGSLGILHELASRGNWNLVAIPKTIDNDVALTERAVGFDTAVNTIVDALNRLTFTAASHDRVMIVEVMGRSAGHLALHAGIAGGADVILIPEISYTISGLCQHIAELRDRWQRKFAIVVVAEGAKLCLEDVQENIASSCAPSKCGRGQYIADQIAQCSKNLIDTRVSVLGHIQRGGIPSALDRLTATVFGKTAVDLIAQGKFGQMVAWQNGEAIPVPIQDVVAQSPLHVNPQGSLVQSARCLGIYVGEKT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000019
EMBL· GenBank· DDBJ
BAB73612.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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