Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

Q8YQD7 · COAX_NOSS1

Function

function

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.

Catalytic activity

Cofactor

NH4+ (UniProtKB | Rhea| CHEBI:28938 )

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: A monovalent cation. Ammonium or potassium.

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.

Features

Showing features for binding site, active site.

127620406080100120140160180200220240260
Type
IDPosition(s)Description
Binding site18-25ATP (UniProtKB | ChEBI)
Binding site116substrate
Binding site120-123substrate
Active site122Proton acceptor
Binding site142K+ (UniProtKB | ChEBI)
Binding site145ATP (UniProtKB | ChEBI)
Binding site200substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpantothenate kinase activity
Biological Processcoenzyme A biosynthetic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Type III pantothenate kinase
  • EC number
  • Alternative names
    • PanK-III
    • Pantothenic acid kinase

Gene names

    • Name
      coaX
    • Ordered locus names
      alr3896

Organism names

Accessions

  • Primary accession
    Q8YQD7

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002708571-276Type III pantothenate kinase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the type III pantothenate kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    276
  • Mass (Da)
    30,272
  • Last updated
    2002-03-01 v1
  • MD5 Checksum
    D242EB0FA372E31E37043C2DDFDB884D
MISQQSAKHIENQWLALEIGNSRLHWALFMGESLEFTWDTEYLPESVIQQLGNGETKLEVGSEEKEIFFTFFPLPPAPCPLPLFIASVVPQQTVLWENYLNVRVITLDQIPLNNIYPTLGIDRALALWGAGMSWGFPVLVIDAGTALTFTAADGGKNLVGGAILPGVGLQFASLGQQTGQLPQVEMEAIKSLPPRFALNTTEAIQSGVIYTLIAGMRDFTEEWLSLFPDGKVAIKGGDRILLLNYLQALYPDLAARLIVEPNLIFWGMQTIVAGVA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000019
EMBL· GenBank· DDBJ
BAB75595.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help