Q8YQ14 · IACT_NOSS1
- ProteinIron and copper transporter IacT
- GeneiacT
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids854 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Involved in the TonB-dependent uptake of copper and iron under conditions in which the concentration of copper exceeds that of the iron.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell outer membrane | |
Molecular Function | copper ion transmembrane transporter activity | |
Molecular Function | iron ion transmembrane transporter activity | |
Biological Process | cellular response to copper ion | |
Biological Process | cellular response to nitrogen starvation | |
Biological Process | copper ion transmembrane transport | |
Biological Process | iron ion transmembrane transport |
Keywords
- Biological process
- Ligand
Community annotation
Involved in metal sensitivity.
Source | Submission date | Contributor |
---|---|---|
PubMed:20647000 | 0000-0002-8506-7364 |
Names & Taxonomy
Protein names
- Recommended nameIron and copper transporter IacT
- Alternative names
Gene names
Community suggested name: Iron and copper transporter IacT; all4026; iacT.
Source | Submission date | Contributor |
---|---|---|
PubMed:20647000 | 0000-0002-8506-7364 |
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Nostocales > Nostocaceae > Nostoc
Accessions
- Primary accessionQ8YQ14
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell outer membrane ; Multi-pass membrane protein
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Viable. Less sensitive to high iron and copper levels than wild-type. Secretes schizokinen even in the presence of iron when grown in BG11 medium or in BG11 without iron and copper as opposed to no secretion of schizokinen in wild-type under these conditions. Secretes schizokinen under iron-limiting conditions similarly to the wild-type. No effect on schizokinen-complexed iron uptake. Contrary to the wild-type, iron uptake is increased when grown in BG11 without iron and copper as well as in BG11 without iron, but addition of copper decreases iron uptake. Decreased copper content compared to wild-type when grown in BG11 medium without iron. Iron uptake is stimulated by copper similarly to the wild-type, but the rate of uptake of both metals is decreased compared to wild-type. Increased survival on high iron concentrations supplied as ferric ammonium citrate (FeACi) compared to wild-type.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000458439 | 1-854 | Iron and copper transporter IacT | ||
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for motif, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Motif | 187-194 | TonB box | |||
Domain | 199-315 | TBDR plug | |||
Domain | 320-854 | TBDR beta-barrel | |||
Motif | 839-854 | TonB C-terminal box | |||
Sequence similarities
Belongs to the TonB-dependent receptor family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length854
- Mass (Da)95,094
- Last updated2002-03-01 v1
- ChecksumA3F03C2A14C90BF0
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BA000019 EMBL· GenBank· DDBJ | BAB75725.1 EMBL· GenBank· DDBJ | Genomic DNA |