Q8Y9G6 · HIS3_LISMO

Function

function

Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site72Mg2+ (UniProtKB | ChEBI)
Binding site73Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site74Mg2+ (UniProtKB | ChEBI)
Binding site76Mg2+ (UniProtKB | ChEBI)
Binding site89Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site96Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmagnesium ion binding
Molecular Functionphosphoribosyl-AMP cyclohydrolase activity
Molecular Functionzinc ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosyl-AMP cyclohydrolase
  • EC number
  • Short names
    PRA-CH

Gene names

    • Name
      hisI
    • Ordered locus names
      lmo0562

Organism names

Accessions

  • Primary accession
    Q8Y9G6

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001364831-105Phosphoribosyl-AMP cyclohydrolase

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the PRA-CH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    105
  • Mass (Da)
    12,046
  • Last updated
    2002-03-01 v1
  • MD5 Checksum
    D8F81C443B3A55F20327B5F2FE97D113
MISVDFSKGLVPTIILDDQNGDVLMLAYMNEESYQKTLETGYTWFFSRSRNELWNKGATSGHTQKVKQIWTDCDNDTLLIRVTQIGPACHTGKKSCFFNLIKEDF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL591975
EMBL· GenBank· DDBJ
CAC98641.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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