Q8Y7I9 · LUXS_LISMO

Function

function

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

Catalytic activity

Cofactor

Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Note: Binds 1 Fe cation per subunit.

Features

Showing features for binding site.

115520406080100120140
TypeIDPosition(s)Description
Binding site57Fe cation (UniProtKB | ChEBI)
Binding site61Fe cation (UniProtKB | ChEBI)
Binding site124Fe cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioniron ion binding
Molecular FunctionS-ribosylhomocysteine lyase activity
Biological Processnegative regulation of single-species biofilm formation on inanimate substrate
Biological Processquorum sensing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-ribosylhomocysteine lyase
  • EC number
  • Alternative names
    • AI-2 synthesis protein
    • Autoinducer-2 production protein LuxS

Gene names

    • Name
      luxS
    • Ordered locus names
      lmo1288

Organism names

Accessions

  • Primary accession
    Q8Y7I9
  • Secondary accessions
    • Q8KYA8

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001722371-155S-ribosylhomocysteine lyase

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the LuxS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    155
  • Mass (Da)
    17,368
  • Last updated
    2002-03-01 v1
  • Checksum
    EC7003D5C9F22248
MAEKMNVESFNLDHTKVKAPFVRLAGTKVGVHGDEIYKYDVRFKQPNKEHMEMPALHSLEHLMAELARNHTDKLVDISPMGCQTGFYVSFINHSDYDDALEIIATTLTDVLVATEVPACNEVQCGWAASHSLEGAKALAEEFLAKRSEWKNVFGE

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict131in Ref. 1; AAM48492

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF084044
EMBL· GenBank· DDBJ
AAM48492.1
EMBL· GenBank· DDBJ
Genomic DNA
AL591978
EMBL· GenBank· DDBJ
CAC99366.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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