Q8XQC5 · SPEE2_RALN1

Function

function

Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.

Catalytic activity

Pathway

Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.

Features

Showing features for binding site, active site.

151050100150200250300350400450500
TypeIDPosition(s)Description
Binding site244S-methyl-5'-thioadenosine (UniProtKB | ChEBI)
Binding site274spermidine (UniProtKB | ChEBI)
Binding site298spermidine (UniProtKB | ChEBI)
Binding site318S-methyl-5'-thioadenosine (UniProtKB | ChEBI)
Binding site352-353S-methyl-5'-thioadenosine (UniProtKB | ChEBI)
Active site370Proton acceptor

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionspermidine synthase activity
Biological Processspermidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Polyamine aminopropyltransferase 2
  • Alternative names
    • Putrescine aminopropyltransferase 2
      (PAPT 2
      )
    • Spermidine synthase 2
      (SPDS 2
      ; SPDSY 2
      ) (EC:2.5.1.16
      ) . EC:2.5.1.16 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      speE2
    • Synonyms
      speE1
    • ORF names
      RS04762
    • Ordered locus names
      RSp1337

Encoded on

  • Plasmid megaplasmid Rsp

Organism names

Accessions

  • Primary accession
    Q8XQC5

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-26Helical
Transmembrane38-58Helical
Transmembrane74-94Helical
Transmembrane102-122Helical
Transmembrane140-160Helical
Transmembrane165-185Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001565001-510Polyamine aminopropyltransferase 2

Interaction

Subunit

Homodimer or homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain205-449PABS
Region207-456Spermidine synthase

Sequence similarities

Belongs to the spermidine/spermine synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    510
  • Mass (Da)
    56,611
  • Last updated
    2002-03-01 v1
  • Checksum
    1814AE8BDA2A56AB
MNRGNALLVLAVFVVASCGLAYELIAGALASYLLGDSILQFSSIIGAYLFAMGIGSWVSRYVADDALLARFVDLELLVGLFGGVSAAALFLLFALESAPFRLVLYALVTVIGVLVGMEIPLVMRMLHRRQAKFSDLVSRVLTFDYLGALAVSLLFPLVLAPRLGLVRTGFLFGLCNTAIAVWTLWHFRAELGLSARLRGAMAWRAGMVGAALLAGFAASDRLTHWSERALFGDEIIHAISSPYQRLVVTRWKDDLRLYINGNLQFSSRDEYRYHEALVLPALESVRGARRVLVLGGGDGLALRQILKYPQVEHVTLVDLDPRMTSLFSHAEALVALNQHAFSDPRVTVVNADAGQWLQTAADMFDVAIVDFPDPSNFSIGKLYSVPFYRLLSRHVADTGLVVIQATSPYFAPRSYWCVDATLKEAGYRTWPYHALVPSFGEWGFILAAPGRADFRPPTTYRVPTRFLDADTTHQMFSFAPDMPRPQVEPNRLNNQSLVRYFEEDWHGVLR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL646053
EMBL· GenBank· DDBJ
CAD18488.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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