Q8XL08 · OGA_CLOPE
- ProteinO-GlcNAcase NagJ
- GenenagJ
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1001 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Binds carbohydrates. Capable of hydrolyzing the glycosidic link of O-GlcNAcylated proteins. Can bind and deglycosylate O-glycosylated peptides from mammals. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates (in vitro).
Catalytic activity
- 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-glucosamine
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 187 | a protein (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 218 | a protein (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 297 | a protein (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 298 | Proton donor | ||||
Sequence: D | ||||||
Binding site | 335 | a protein (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 394-396 | a protein (UniProtKB | ChEBI) | ||||
Sequence: WWN | ||||||
Binding site | 401 | a protein (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 429 | a protein (UniProtKB | ChEBI) | ||||
Sequence: N |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity | |
Molecular Function | beta-N-acetylglucosaminidase activity | |
Molecular Function | carbohydrate binding | |
Biological Process | carbohydrate derivative metabolic process | |
Biological Process | polysaccharide catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameO-GlcNAcase NagJ
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium
Accessions
- Primary accessionQ8XL08
Proteomes
Phenotypes & Variants
Chemistry
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-30 | |||||
Sequence: MKRKMLKRLLTSAFACMFIANGLITTTVRA | ||||||
Chain | PRO_0000257986 | 31-1001 | O-GlcNAcase NagJ | |||
Sequence: VGPKTGEENQVLVPNLNPTPENLEVVGDGFKITSSINLVGEEEADENAVNALREFLTANNIEINSENDPNSTTLIIGEVDDDIPELDEALNGTTAENLKEEGYALVSNDGKIAIEGKDGDGTFYGVQTFKQLVKESNIPEVNITDYPTVSARGIVEGFYGTPWTHKDRLDQIKFYGENKLNTYIYAPKDDPYHREKWREPYPENEMQRMQELIDASAENKVDFVFGISPGIDIRFDGEAGEEDFNHLIAKAESLYDMGVRSFAIYWDDIQDKSAAKHAQVLNRFNEEFVKAKGDVKPLITVPTEYDTGAMVSNGQPRTYTRIFAETVDPSIEVMWTGPGVVTNEIPLSDAQLISGIYNRNMAVWWNYPVTDYFKGKLALGPMHGLDKGLNQYVDFFTVNPMEHAELSKISIHTAADYSWNMDNYDYDKAWNRAIDMLYGDLAEDMKVFANHSTRMDNKTWAKSGREDAPELRAKMDELWNKLSSKEDASALIEELYGEFARMEEACNNLKANLPEVALEECSRQLDELITLAQGDKASLDMIVAQLNEDTEAYESAKEIAQNKLNTALSSFAVISEKVAQSFIQEALSFDLTLINPRTVKITASSEETSGENAPASFASDGDMNTFWHSKWSSPAHEGPHHLTLELDNVYEINKVKYAPRQDSKNGRITGYKVSVSLDGENFTEVKTGTLEDNAAIKFIEFDSVDAKYVRLDVTDSVSDQANGRGKFATAAEVNVHGKLKEAAEVTGSVSLEALEEVQVGENIEVGVGIDELVNAEAFAYDFTLNYDENAFEYVEAISDDGVFVNAKKIEDGKVRVLVSSLTGEPLPAKEVLAKVVLRAEAKTEGSNLSVTNSSVGDGEGLVHEIAGTEKTVNIIEGTSPEIVVNPVRDFKASEINKKNVTVTWTEPETTEGLEGYILYKDGKKVAEIGKDETSYTFKKLNRHTIYNFKIAAKYSNGEVSSKESLTLRTAR |
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8XL08 | nagH P26831 | 3 | EBI-15722628, EBI-15722600 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 179-469 | Catalytic domain | ||||
Sequence: VSARGIVEGFYGTPWTHKDRLDQIKFYGENKLNTYIYAPKDDPYHREKWREPYPENEMQRMQELIDASAENKVDFVFGISPGIDIRFDGEAGEEDFNHLIAKAESLYDMGVRSFAIYWDDIQDKSAAKHAQVLNRFNEEFVKAKGDVKPLITVPTEYDTGAMVSNGQPRTYTRIFAETVDPSIEVMWTGPGVVTNEIPLSDAQLISGIYNRNMAVWWNYPVTDYFKGKLALGPMHGLDKGLNQYVDFFTVNPMEHAELSKISIHTAADYSWNMDNYDYDKAWNRAIDMLYG | ||||||
Domain | 180-452 | GH84 | ||||
Sequence: SARGIVEGFYGTPWTHKDRLDQIKFYGENKLNTYIYAPKDDPYHREKWREPYPENEMQRMQELIDASAENKVDFVFGISPGIDIRFDGEAGEEDFNHLIAKAESLYDMGVRSFAIYWDDIQDKSAAKHAQVLNRFNEEFVKAKGDVKPLITVPTEYDTGAMVSNGQPRTYTRIFAETVDPSIEVMWTGPGVVTNEIPLSDAQLISGIYNRNMAVWWNYPVTDYFKGKLALGPMHGLDKGLNQYVDFFTVNPMEHAELSKISIHTAADYSWNMD | ||||||
Coiled coil | 515-543 | |||||
Sequence: KEDASALIEELYGEFARMEEACNNLKANL | ||||||
Coiled coil | 573-597 | |||||
Sequence: VAQLNEDTEAYESAKEIAQNKLNTA | ||||||
Domain | 916-1001 | Fibronectin type-III | ||||
Sequence: PVRDFKASEINKKNVTVTWTEPETTEGLEGYILYKDGKKVAEIGKDETSYTFKKLNRHTIYNFKIAAKYSNGEVSSKESLTLRTAR |
Sequence similarities
Belongs to the glycosyl hydrolase 84 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length1,001
- Mass (Da)111,109
- Last updated2002-03-01 v1
- ChecksumE0C0A1575073946E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BA000016 EMBL· GenBank· DDBJ | BAB80940.1 EMBL· GenBank· DDBJ | Genomic DNA |