Q8X9B6 · ACCC_ECO57

Function

function

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 magnesium or manganese ions per subunit.

Pathway

Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site116ATP (UniProtKB | ChEBI)
Binding site159ATP (UniProtKB | ChEBI)
Binding site165-166ATP (UniProtKB | ChEBI)
Binding site201-204ATP (UniProtKB | ChEBI)
Binding site209ATP (UniProtKB | ChEBI)
Binding site236ATP (UniProtKB | ChEBI)
Binding site238hydrogencarbonate (UniProtKB | ChEBI)
Binding site276ATP (UniProtKB | ChEBI)
Binding site276Mg2+ 1 (UniProtKB | ChEBI)
Binding site276Mn2+ 1 (UniProtKB | ChEBI)
Binding site288ATP (UniProtKB | ChEBI)
Binding site288Mg2+ 1 (UniProtKB | ChEBI)
Binding site288Mg2+ 2 (UniProtKB | ChEBI)
Binding site288Mn2+ 1 (UniProtKB | ChEBI)
Binding site288Mn2+ 2 (UniProtKB | ChEBI)
Binding site290Mg2+ 2 (UniProtKB | ChEBI)
Binding site290Mn2+ 2 (UniProtKB | ChEBI)
Active site292
Binding site292hydrogencarbonate (UniProtKB | ChEBI)
Binding site295hydrogencarbonate (UniProtKB | ChEBI)
Binding site338biotin (UniProtKB | ChEBI)
Binding site338hydrogencarbonate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionacetyl-CoA carboxylase activity
Molecular FunctionATP binding
Molecular Functionbiotin carboxylase activity
Molecular Functionmetal ion binding
Biological Processfatty acid biosynthetic process
Biological Processmalonyl-CoA biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Biotin carboxylase
  • EC number
  • Alternative names
    • Acetyl-coenzyme A carboxylase biotin carboxylase subunit A

Gene names

    • Name
      accC
    • Ordered locus names
      Z4616, ECs4128

Organism names

  • Taxonomic identifier
  • Strains
    • O157:H7 / EDL933 / ATCC 700927 / EHEC
    • O157:H7 / Sakai / RIMD 0509952 / EHEC
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    Q8X9B6

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001467921-449Biotin carboxylase

Interaction

Subunit

Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-445Biotin carboxylation
Domain120-317ATP-grasp

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    449
  • Mass (Da)
    49,337
  • Last updated
    2002-03-05 v1
  • Checksum
    BC5716323F6233ED
MLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETVCIGPAPSVKSYLNIPAIISAAEITGAVAIHPGYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAIAAMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKASGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYMEKYLENPRHVEIQVLADGQGNSIYLAERDCSMQRRHQKVVEEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQPLSIKQEEVHVRGHAVECRINAEDPNTFLPSPGKITRFHAPGGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIARMKNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYLEKKLGLQEK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE005174
EMBL· GenBank· DDBJ
AAG58384.1
EMBL· GenBank· DDBJ
Genomic DNA
BA000007
EMBL· GenBank· DDBJ
BAB37551.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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