Q8X8T3 · HISX_ECO57

Function

function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site130NAD+ (UniProtKB | ChEBI)
Binding site188NAD+ (UniProtKB | ChEBI)
Binding site211NAD+ (UniProtKB | ChEBI)
Binding site237substrate
Binding site259substrate
Binding site259Zn2+ (UniProtKB | ChEBI)
Binding site262substrate
Binding site262Zn2+ (UniProtKB | ChEBI)
Active site326Proton acceptor
Active site327Proton acceptor
Binding site327substrate
Binding site360substrate
Binding site360Zn2+ (UniProtKB | ChEBI)
Binding site414substrate
Binding site419substrate
Binding site419Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionhistidinol dehydrogenase activity
Molecular FunctionNAD binding
Molecular Functionzinc ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histidinol dehydrogenase
  • EC number
  • Short names
    HDH

Gene names

    • Name
      hisD
    • Ordered locus names
      Z3182, ECs2821

Organism names

  • Taxonomic identifier
  • Strains
    • O157:H- / 184 / EHEC
    • O157:H7 / EDL933 / ATCC 700927 / EHEC
    • O157:H7 / Sakai / RIMD 0509952 / EHEC
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    Q8X8T3
  • Secondary accessions
    • Q9WX45

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for initiator methionine, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00001357712-434Histidinol dehydrogenase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    434
  • Mass (Da)
    46,074
  • Last updated
    2007-01-23 v3
  • Checksum
    A280AE06E39689C8
MSFNTIIDWNSCTAKQQRQLLMRPAISASESITRTVNDILDSVKARGDDALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPARIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPDADMAHQVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDGITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKVGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB008676
EMBL· GenBank· DDBJ
BAA77745.1
EMBL· GenBank· DDBJ
Genomic DNA
AE005174
EMBL· GenBank· DDBJ
AAG57079.1
EMBL· GenBank· DDBJ
Genomic DNA
BA000007
EMBL· GenBank· DDBJ
BAB36244.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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