Q8WXI3 · ASB10_HUMAN
- ProteinAnkyrin repeat and SOCS box protein 10
- GeneASB10
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids467 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Pathway
Protein modification; protein ubiquitination.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Biological Process | intracellular signal transduction | |
Biological Process | protein ubiquitination |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAnkyrin repeat and SOCS box protein 10
- Short namesASB-10
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8WXI3
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Involvement in disease
Glaucoma 1, open angle, F (GLC1F)
- Note
- DescriptionA form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
- See alsoMIM:603383
Natural variants in GLC1F
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_082796 | 19 | P>S | In isoform Q8WXI3-3; in GLC1F; uncertain significance; dbSNP:rs104886462 | |
VAR_082797 | 32 | R>S | In isoform Q8WXI3-3; in GLC1F; uncertain significance; dbSNP:rs104886465 | |
VAR_082798 | 39 | R>Q | In isoform Q8WXI3-3; in GLC1F; uncertain significance; dbSNP:rs104886467 | |
VAR_069867 | 48 | T>S | in GLC1F; uncertain significance; dbSNP:rs151344615 | |
VAR_069868 | 65 | G>E | in GLC1F; uncertain significance; dbSNP:rs104886491 | |
VAR_069869 | 67 | V>M | in GLC1F; uncertain significance; dbSNP:rs151344616 | |
VAR_069870 | 72 | R>H | in GLC1F; uncertain significance; dbSNP:rs104886488 | |
VAR_069873 | 94 | R>Q | in GLC1F; uncertain significance; dbSNP:rs147737381 | |
VAR_069874 | 97 | D>E | in GLC1F; uncertain significance; dbSNP:rs151344619 | |
VAR_069876 | 183 | R>C | in GLC1F; uncertain significance; dbSNP:rs151344605 | |
VAR_069878 | 197 | A>V | in GLC1F; uncertain significance; dbSNP:rs151344607 | |
VAR_069879 | 207 | V>L | in GLC1F; uncertain significance; dbSNP:rs104886474 | |
VAR_069881 | 272 | R>H | in GLC1F; uncertain significance; dbSNP:rs140602973 | |
VAR_069882 | 295 | Q>L | in GLC1F; uncertain significance; dbSNP:rs151344609 | |
VAR_069884 | 320 | A>T | in GLC1F; uncertain significance; dbSNP:rs151344610 | |
VAR_069886 | 332 | H>Q | in GLC1F; uncertain significance; dbSNP:rs104886482 | |
VAR_069887 | 356 | H>Y | in GLC1F; uncertain significance; dbSNP:rs151344611 | |
VAR_069888 | 360 | R>H | in GLC1F; uncertain significance; dbSNP:rs151344612 | |
VAR_069891 | 440 | S>G | in GLC1F; uncertain significance; dbSNP:rs104886487 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_082796 | 19 | In isoform Q8WXI3-3; in GLC1F; uncertain significance; dbSNP:rs104886462 | |||
Sequence: P → S | ||||||
Natural variant | VAR_082797 | 32 | In isoform Q8WXI3-3; in GLC1F; uncertain significance; dbSNP:rs104886465 | |||
Sequence: R → S | ||||||
Natural variant | VAR_082798 | 39 | In isoform Q8WXI3-3; in GLC1F; uncertain significance; dbSNP:rs104886467 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_069867 | 48 | in GLC1F; uncertain significance; dbSNP:rs151344615 | |||
Sequence: T → S | ||||||
Natural variant | VAR_069868 | 65 | in GLC1F; uncertain significance; dbSNP:rs104886491 | |||
Sequence: G → E | ||||||
Natural variant | VAR_069869 | 67 | in GLC1F; uncertain significance; dbSNP:rs151344616 | |||
Sequence: V → M | ||||||
Natural variant | VAR_069870 | 72 | in GLC1F; uncertain significance; dbSNP:rs104886488 | |||
Sequence: R → H | ||||||
Natural variant | VAR_069871 | 88 | in dbSNP:rs151344617 | |||
Sequence: D → V | ||||||
Natural variant | VAR_069872 | 91 | in dbSNP:rs104886490 | |||
Sequence: D → Y | ||||||
Natural variant | VAR_069873 | 94 | in GLC1F; uncertain significance; dbSNP:rs147737381 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_069874 | 97 | in GLC1F; uncertain significance; dbSNP:rs151344619 | |||
Sequence: D → E | ||||||
Natural variant | VAR_069875 | 172 | in dbSNP:rs151344604 | |||
Sequence: A → V | ||||||
Natural variant | VAR_069876 | 183 | in GLC1F; uncertain significance; dbSNP:rs151344605 | |||
Sequence: R → C | ||||||
Natural variant | VAR_069877 | 189 | in dbSNP:rs104886473 | |||
Sequence: R → W | ||||||
Natural variant | VAR_069878 | 197 | in GLC1F; uncertain significance; dbSNP:rs151344607 | |||
Sequence: A → V | ||||||
Natural variant | VAR_069879 | 207 | in GLC1F; uncertain significance; dbSNP:rs104886474 | |||
Sequence: V → L | ||||||
Natural variant | VAR_069880 | 237 | in dbSNP:rs61735708 | |||
Sequence: R → G | ||||||
Natural variant | VAR_069881 | 272 | in GLC1F; uncertain significance; dbSNP:rs140602973 | |||
Sequence: R → H | ||||||
Natural variant | VAR_069882 | 295 | in GLC1F; uncertain significance; dbSNP:rs151344609 | |||
Sequence: Q → L | ||||||
Natural variant | VAR_069883 | 304 | in dbSNP:rs61735130 | |||
Sequence: R → C | ||||||
Natural variant | VAR_069884 | 320 | in GLC1F; uncertain significance; dbSNP:rs151344610 | |||
Sequence: A → T | ||||||
Natural variant | VAR_069885 | 329 | in dbSNP:rs104886481 | |||
Sequence: T → M | ||||||
Natural variant | VAR_069886 | 332 | in GLC1F; uncertain significance; dbSNP:rs104886482 | |||
Sequence: H → Q | ||||||
Natural variant | VAR_069887 | 356 | in GLC1F; uncertain significance; dbSNP:rs151344611 | |||
Sequence: H → Y | ||||||
Natural variant | VAR_069888 | 360 | in GLC1F; uncertain significance; dbSNP:rs151344612 | |||
Sequence: R → H | ||||||
Natural variant | VAR_069889 | 372 | in dbSNP:rs62489646 | |||
Sequence: R → C | ||||||
Natural variant | VAR_069890 | 402 | in dbSNP:rs919533 | |||
Sequence: P → T | ||||||
Natural variant | VAR_069891 | 440 | in GLC1F; uncertain significance; dbSNP:rs104886487 | |||
Sequence: S → G | ||||||
Natural variant | VAR_022090 | 453 | in dbSNP:rs3800791 | |||
Sequence: R → C |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 638 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000066942 | 1-467 | Ankyrin repeat and SOCS box protein 10 | |||
Sequence: MLMSWSPEECKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the eye. The highest expression is observed in the iris, with moderate levels in the trabecular meshwork (TM), the lamina, and the optic nerve; slightly lower levels in the ciliary body, retina, and choroid; and very low levels in the lens.
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8WXI3 | LCN2 P80188 | 3 | EBI-3923154, EBI-11911016 | |
BINARY | Q8WXI3 | MEOX2 Q6FHY5 | 3 | EBI-3923154, EBI-16439278 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for repeat, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 115-144 | ANK 1 | ||||
Sequence: ELTTPLHVAASRGHTEVLRLLLRRRARPDS | ||||||
Repeat | 147-176 | ANK 2 | ||||
Sequence: GGRTALHEACAAGHTACVHVLLVAGADPNI | ||||||
Repeat | 180-209 | ANK 3 | ||||
Sequence: DGKRPLHLCRGPGTLECAELLLRFGARVDG | ||||||
Repeat | 214-243 | ANK 4 | ||||
Sequence: EEETPLHVAARLGHVELADLLLRRGACPDA | ||||||
Repeat | 247-289 | ANK 5 | ||||
Sequence: EGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADA | ||||||
Repeat | 293-322 | ANK 6 | ||||
Sequence: DKQRPLHLACRRGHAAVVELLLSCGVSANT | ||||||
Repeat | 326-361 | ANK 7 | ||||
Sequence: GGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRV | ||||||
Domain | 412-464 | SOCS box | ||||
Sequence: YSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEG |
Domain
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Sequence similarities
Belongs to the ankyrin SOCS box (ASB) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q8WXI3-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length467
- Mass (Da)50,894
- Last updated2007-02-20 v2
- Checksum7C92C07B154479DE
Q8WXI3-2
- Name2
- Differences from canonical
- 369-406: Missing
Q8WXI3-3
- Name3
- Differences from canonical
- 1-106: MLMSWSPEECKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALR → MPWGKNSSPHWGHHLGCLPSAPACRIWRPHSRPAWEPPRPSPLLCQDMALQNALYTGDLARLQELFPPHSTADLLLESRAAEPRWSSHQRG
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F8WB38 | F8WB38_HUMAN | ASB10 | 115 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_038997 | 1-106 | in isoform 3 | |||
Sequence: MLMSWSPEECKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALR → MPWGKNSSPHWGHHLGCLPSAPACRIWRPHSRPAWEPPRPSPLLCQDMALQNALYTGDLARLQELFPPHSTADLLLESRAAEPRWSSHQRG | ||||||
Alternative sequence | VSP_023357 | 369-406 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 421 | in Ref. 2; BAC86204 | ||||
Sequence: Q → R | ||||||
Sequence conflict | 433 | in Ref. 2; BAC86204 | ||||
Sequence: L → P |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF417920 EMBL· GenBank· DDBJ | AAL59159.1 EMBL· GenBank· DDBJ | mRNA | ||
AK125565 EMBL· GenBank· DDBJ | BAC86204.1 EMBL· GenBank· DDBJ | mRNA | ||
AC010973 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC126351 EMBL· GenBank· DDBJ | AAI26352.1 EMBL· GenBank· DDBJ | mRNA |