Q8WXI2 · CNKR2_HUMAN

  • Protein
    Connector enhancer of kinase suppressor of ras 2
  • Gene
    CNKSR2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May function as an adapter protein or regulator of Ras signaling pathways.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular exosome
Cellular Componentextrinsic component of postsynaptic density membrane
Cellular Componentglutamatergic synapse
Cellular Componentneuronal cell body
Cellular Componentplasma membrane
Molecular Functionidentical protein binding
Molecular Functionprotein kinase binding
Biological Processintracellular signal transduction
Biological Processpostsynapse organization
Biological Processregulation of signal transduction

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Connector enhancer of kinase suppressor of ras 2
  • Short names
    Connector enhancer of KSR 2
  • Alternative names
    • CNK homolog protein 2 (CNK2)

Gene names

    • Name
      CNKSR2
    • Synonyms
      CNK2, KIAA0902, KSR2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8WXI2
  • Secondary accessions
    • B4DGR4
    • B7ZLJ1
    • B9EG83
    • E7ESA4
    • O94976

Proteomes

Organism-specific databases

Disease & Variants

Involvement in disease

Intellectual developmental disorder, X-linked, syndromic, Houge type (MRXSHG)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    A disorder characterized by delayed development, intellectual disability, speech and language delay, and early-onset seizures. Carrier females may be mildly affected.
  • See also
    MIM:301008
Natural variants in MRXSHG
Variant IDPosition(s)ChangeDescription
VAR_080600712-1034missingin MRXSHG

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_03568146in a colorectal cancer sample; somatic mutation; dbSNP:rs771705122
Natural variantVAR_080600712-1034in MRXSHG

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 720 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00000899701-1034UniProtConnector enhancer of kinase suppressor of ras 2
Modified residue12UniProtPhosphoserine
Modified residue (large scale data)248PRIDEPhosphoserine
Modified residue (large scale data)325PRIDEPhosphoserine
Modified residue338UniProtPhosphoserine
Modified residue (large scale data)388PRIDEPhosphoserine
Modified residue390UniProtPhosphoserine
Modified residue (large scale data)390PRIDEPhosphoserine
Modified residue683UniProtPhosphotyrosine
Modified residue685UniProtPhosphoserine
Modified residue (large scale data)685PRIDEPhosphoserine
Modified residue687UniProtPhosphoserine
Modified residue (large scale data)687PRIDEPhosphoserine
Modified residue756UniProtPhosphoserine
Modified residue767UniProtPhosphoserine
Modified residue908UniProtPhosphoserine
Modified residue (large scale data)908PRIDEPhosphoserine

Post-translational modification

Phosphorylated on tyrosine.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with RAF1, RAB2L and RAL GTPase proteins.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
XENO Q8WXI2ave Q8ML925EBI-1045119, EBI-2563975
BINARY Q8WXI2EGFR P005332EBI-1045119, EBI-297353

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, compositional bias, region, coiled coil.

TypeIDPosition(s)Description
Domain11-76SAM
Domain84-178CRIC
Domain215-297PDZ
Compositional bias324-346Polar residues
Region324-349Disordered
Domain332-515DUF1170
Region480-510Disordered
Region539-559Disordered
Compositional bias543-559Basic residues
Domain570-669PH
Compositional bias682-696Basic and acidic residues
Region682-766Disordered
Compositional bias698-712Pro residues
Compositional bias726-766Polar residues
Region864-905Disordered
Compositional bias871-890Acidic residues
Coiled coil875-904
Compositional bias891-905Basic and acidic residues

Sequence similarities

Belongs to the CNKSR family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q8WXI2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    CNK2A, KSR2A
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    1,034
  • Mass (Da)
    117,535
  • Last updated
    2002-03-01 v1
  • Checksum
    E43DB0D8D72D954C
MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLAHTHSYIETHV

Q8WXI2-2

  • Name
    2
  • Synonyms
    CNK2B, KSR2B
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q8WXI2-4

Q8WXI2-5

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 15 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2R8Y7K8A0A2R8Y7K8_HUMANCNKSR2680
A0A2R8Y7A1A0A2R8Y7A1_HUMANCNKSR2985
A0A2R8Y700A0A2R8Y700_HUMANCNKSR2955
A0A2R8Y5S6A0A2R8Y5S6_HUMANCNKSR2815
A0A2R8Y5R2A0A2R8Y5R2_HUMANCNKSR2300
A0A2R8Y604A0A2R8Y604_HUMANCNKSR2253
A0A2R8Y622A0A2R8Y622_HUMANCNKSR2819
A0A2R8YGJ7A0A2R8YGJ7_HUMANCNKSR2856
A0A2R8YE65A0A2R8YE65_HUMANCNKSR2220
A0A2R8YE71A0A2R8YE71_HUMANCNKSR2616
A0A2R8YE27A0A2R8YE27_HUMANCNKSR2591
A0A2R8YDB6A0A2R8YDB6_HUMANCNKSR2302
A0A2R8YFM1A0A2R8YFM1_HUMANCNKSR2681
A0A2R8YED7A0A2R8YED7_HUMANCNKSR21009
A0A2U3TZH5A0A2U3TZH5_HUMANCNKSR2868

Sequence caution

The sequence BAA74925.2 differs from that shown. Reason: Frameshift

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_043168271-319in isoform 3
Compositional bias324-346Polar residues
Alternative sequenceVSP_043169435-464in isoform 4
Compositional bias543-559Basic residues
Compositional bias682-696Basic and acidic residues
Compositional bias698-712Pro residues
Compositional bias726-766Polar residues
Compositional bias871-890Acidic residues
Compositional bias891-905Basic and acidic residues
Alternative sequenceVSP_010887899-1034in isoform 2 and isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF418269
EMBL· GenBank· DDBJ
AAL60502.1
EMBL· GenBank· DDBJ
mRNA
AF418270
EMBL· GenBank· DDBJ
AAL60503.1
EMBL· GenBank· DDBJ
mRNA
AB020709
EMBL· GenBank· DDBJ
BAA74925.2
EMBL· GenBank· DDBJ
mRNA Frameshift
AK294728
EMBL· GenBank· DDBJ
BAG57875.1
EMBL· GenBank· DDBJ
mRNA
AL928874
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL807781
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL772392
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471074
EMBL· GenBank· DDBJ
EAW98977.1
EMBL· GenBank· DDBJ
Genomic DNA
BC126121
EMBL· GenBank· DDBJ
AAI26122.1
EMBL· GenBank· DDBJ
mRNA
BC136289
EMBL· GenBank· DDBJ
AAI36290.1
EMBL· GenBank· DDBJ
mRNA
BC143839
EMBL· GenBank· DDBJ
AAI43840.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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