Cell viability and surface expression of transferrin receptor (CD71) and glycophorin A (GPA) were analyzed before and after re-culture by flow cytometry. These studies show differential sensitivities of these surface proteins on K562 cells to proteases and suggest molecular mechanisms of transmembrane protein transport and cycling.
a complex structural rearrangement involving the loss of GYPB and gain of two GYPB-A hybrid genes reduces the risk of severe malaria by 40% and has recently increased in frequency in parts of Kenya
While weak interactions between glycophorin and band 3 undoubtedly exist glycophorin A and band 3 must have separate interactions in the membrane that control their lateral mobility.
The authors demonstrate that the initial vacuolar membrane around internalized Babesia divergens is formed from protein and lipid components of the red blood cells plasma membrane including band 3 glycophorin A and spectrin.
Data suggest that glycophorin A (Gpa) increases expression and activity of Cl-/HCO3- exchanger Ae1 that G719D mutation renders Ae1 mutant constructs GPA-unresponsive and suggests a role for Ae1 amino acids 22-28 in GPA responsiveness.
Heterozygous missense mutation E758K in the human AE1/SLC4A1/band 3 gene in two unrelated patients with well-compensated hereditary spherostomatocytic anemia induces glycophorin A-independent endogenous cation transport.
Not Associated with CARDIOVASCULAR: cerebral malaria., Observational study of gene-disease association. (HuGE Navigator); GYPA & GYPB genotypes carrying MNSs antigens were analyzed in Thai patients with cerebral malaria & mild malaria; no statistical difference was found; it is concluded that MNSs antigens do not reveal the difference in susceptibility to cerebral malaria
band 3 in the red cell can take up two different structures: one with high anion transport activity when glycophorin A is present and one with lower anion transport activity when glycophorin A is absent
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.