Q8WV16 · DCAF4_HUMAN

  • Protein
    DDB1- and CUL4-associated factor 4
  • Gene
    DCAF4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCul4-RING E3 ubiquitin ligase complex
Cellular Componentnucleoplasm
Biological Processprotein ubiquitination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DDB1- and CUL4-associated factor 4
  • Alternative names
    • WD repeat-containing protein 21A

Gene names

    • Name
      DCAF4
    • Synonyms
      WDR21, WDR21A

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8WV16
  • Secondary accessions
    • B4DUT6
    • G3V522
    • Q86U31
    • Q8IV10
    • Q96K22
    • Q9Y4P5

Proteomes

Organism-specific databases

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_02790822in dbSNP:rs2302588
Natural variantVAR_027909193in dbSNP:rs17856582
Natural variantVAR_027910266in dbSNP:rs7155812
Natural variantVAR_027911334in dbSNP:rs17856583
Natural variantVAR_027912345in dbSNP:rs3815460
Natural variantVAR_027913439in dbSNP:rs17856584

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 570 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000513681-495DDB1- and CUL4-associated factor 4

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with DDB1 and CUL4A.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q8WV16DDB1 Q165317EBI-2559135, EBI-350322
BINARY Q8WV16ST7 Q9NRC13EBI-2559135, EBI-3911844
BINARY Q8WV16-4ATXN1 P542533EBI-20852566, EBI-930964
View interactors in UniProtKB
View CPX-2799 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for compositional bias, region, repeat.

TypeIDPosition(s)Description
Compositional bias1-19Basic residues
Region1-66Disordered
Compositional bias20-48Basic and acidic residues
Repeat368-407WD 1
Repeat410-451WD 2

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (5)
  • Sequence status
    Complete

This entry describes 5 isoforms produced by Alternative splicing.

Q8WV16-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    495
  • Mass (Da)
    55,694
  • Last updated
    2006-10-17 v3
  • Checksum
    F104B7F1FC6B5C33
MNKSRWQSRRRHGRRSHQQNPWFRLRDSEDRSDSRAAQPAHDSGHGDDESPSTSSGTAGTSSVPELPGFYFDPEKKRYFRLLPGHNNCNPLTKESIRQKEMESKRLRLLQEEDRRKKIARMGFNASSMLRKSQLGFLNVTNYCHLAHELRLSCMERKKVQIRSMDPSALASDRFNLILADTNSDRLFTVNDVKVGGSKYGIINLQSLKTPTLKVFMHENLYFTNRKVNSVCWASLNHLDSHILLCLMGLAETPGCATLLPASLFVNSHPGIDRPGMLCSFRIPGAWSCAWSLNIQANNCFSTGLSRRVLLTNVVTGHRQSFGTNSDVLAQQFALMAPLLFNGCRSGEIFAIDLRCGNQGKGWKATRLFHDSAVTSVRILQDEQYLMASDMAGKIKLWDLRTTKCVRQYEGHVNEYAYLPLHVHEEEGILVAVGQDCYTRIWSLHDARLLRTIPSPYPASKADIPSVAFSSRLGGSRGAPGLLMAVGQDLYCYSYS

Q8WV16-2

Q8WV16-3

Q8WV16-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q8WV16-5

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D6RCB5D6RCB5_HUMANDCAF474
G3V3D6G3V3D6_HUMANDCAF4333
Q86SY2Q86SY2_HUMANDCAF4325

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-19Basic residues
Alternative sequenceVSP_0454271-100in isoform 4
Sequence conflict4in Ref. 5; CAB45748
Compositional bias20-48Basic and acidic residues
Sequence conflict35in Ref. 2; BAB55337
Sequence conflict45in Ref. 2; BAB55337
Sequence conflict65in Ref. 2; BAB55337
Alternative sequenceVSP_047171118-178in isoform 3
Alternative sequenceVSP_047172269in isoform 3 and isoform 5
Alternative sequenceVSP_047173329-335in isoform 5
Alternative sequenceVSP_020986432-433in isoform 2
Alternative sequenceVSP_020987434-495in isoform 2

Polymorphism

An intronic G-to-A transition (rs2535913) has been associated with leukocyte telomere length. The minor A allele is associated with shorter telomeres and lower expression in lymphoblastoid cells and in sun-exposed skin (PubMed:25624462).

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX247962
EMBL· GenBank· DDBJ
CAD62301.1
EMBL· GenBank· DDBJ
mRNA
AK027745
EMBL· GenBank· DDBJ
BAB55337.1
EMBL· GenBank· DDBJ
mRNA
AK300786
EMBL· GenBank· DDBJ
BAG62448.1
EMBL· GenBank· DDBJ
mRNA
AC007160
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL442663
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC018979
EMBL· GenBank· DDBJ
AAH18979.1
EMBL· GenBank· DDBJ
mRNA
BC035901
EMBL· GenBank· DDBJ
AAH35901.1
EMBL· GenBank· DDBJ
mRNA
AL080157
EMBL· GenBank· DDBJ
CAB45748.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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