Q8WV07 · LTO1_HUMAN

  • Protein
    Protein LTO1 homolog
  • Gene
    LTO1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403).
May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:23318452).
May play a role in the regulation of proline metabolism and ROS production (PubMed:24930674).

Miscellaneous

Amplified and overexpressed in oral cancer cells.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Biological Processprotein maturation by [4Fe-4S] cluster transfer
Biological Processribosomal large subunit biogenesis
Biological Processtelomere maintenance
Biological Processtranslational initiation

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein LTO1 homolog
  • Alternative names
    • Oral cancer-overexpressed protein 1
    • Tumor-amplified and overexpressed sequence 1

Gene names

    • Name
      LTO1
    • Synonyms
      ORAOV1
      , TAOS1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8WV07
  • Secondary accessions
    • B2R4R2
    • Q8NFK0

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_0622313in dbSNP:rs56107468

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 178 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Initiator methionine1UniProtRemoved
Modified residue2UniProtN-acetylalanine
ChainPRO_00000580752-137UniProtProtein LTO1 homolog
Modified residue4UniProtPhosphoserine
Modified residue (large scale data)4PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed. Highly expressed in placenta, kidney and skeletal muscle.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Forms a complex with YAE1 (PubMed:23318452).
Interacts with PYCR1 and PYCR2 (PubMed:24930674).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q8WV07GSC2 O154993EBI-12249832, EBI-19954058
BINARY Q8WV07YAE1 Q9NRH18EBI-12249832, EBI-712905

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region22-58deca-GX3 motif; required for interaction with YAE1 and the CIA complex

Sequence similarities

Belongs to the LTO1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    137
  • Mass (Da)
    15,354
  • Last updated
    2004-03-01 v2
  • Checksum
    7FD11DF1C08DD37A
MAGSQDIFDAIVMADERFHGEGYREGYEEGSSLGVMEGRQHGTLHGAKIGSEIGCYQGFAFAWKCLLHSCTTEKDSRKMKVLESLIGMIQKFPYDDPTYDKLHEDLDKIRGKFKQFCSLLNVQPDFKISAEGSGLSF

Computationally mapped potential isoform sequences

There are 8 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H3BPK6H3BPK6_HUMANLTO162
B4DFA5B4DFA5_HUMANLTO1221
F5GZY6F5GZY6_HUMANLTO1124
F5GWS9F5GWS9_HUMANLTO178
A6YPU5A6YPU5_HUMANLTO170
F5H6T8F5H6T8_HUMANLTO176
F5H8D9F5H8D9_HUMANLTO136
F5H179F5H179_HUMANLTO143

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF503940
EMBL· GenBank· DDBJ
AAM97902.1
EMBL· GenBank· DDBJ
mRNA
AK311918
EMBL· GenBank· DDBJ
BAG34859.1
EMBL· GenBank· DDBJ
mRNA
CH471076
EMBL· GenBank· DDBJ
EAW74749.1
EMBL· GenBank· DDBJ
Genomic DNA
BC019024
EMBL· GenBank· DDBJ
AAH19024.4
EMBL· GenBank· DDBJ
mRNA
BC065542
EMBL· GenBank· DDBJ
AAH65542.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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