Q8WUZ0 · BCL7C_HUMAN

  • Protein
    B-cell CLL/lymphoma 7 protein family member C
  • Gene
    BCL7C
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

May play an anti-apoptotic role.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular ComponentGBAF complex
Cellular Componentnucleoplasm
Cellular ComponentSWI/SNF complex
Biological Processapoptotic process
Biological Processchromatin remodeling
Biological Processnegative regulation of cell differentiation
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of double-strand break repair
Biological Processpositive regulation of stem cell population maintenance
Biological Processregulation of G0 to G1 transition
Biological Processregulation of G1/S transition of mitotic cell cycle
Biological Processregulation of mitotic metaphase/anaphase transition
Biological Processregulation of nucleotide-excision repair
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    B-cell CLL/lymphoma 7 protein family member C

Gene names

    • Name
      BCL7C

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8WUZ0
  • Secondary accessions
    • O43770
    • Q6PD89

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 243 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
ChainPRO_00002398331-217UniProtB-cell CLL/lymphoma 7 protein family member C
Modified residue (large scale data)80PRIDEPhosphoserine
Modified residue97UniProtPhosphoserine
Modified residue (large scale data)97PRIDEPhosphoserine
Modified residue100UniProtPhosphoserine
Modified residue (large scale data)100PRIDEPhosphoserine
Modified residue103UniProtPhosphoserine
Modified residue (large scale data)103PRIDEPhosphoserine
Modified residue (large scale data)106PRIDEPhosphoserine
Modified residue111UniProtPhosphothreonine
Modified residue (large scale data)111PRIDEPhosphothreonine
Modified residue114UniProtPhosphoserine
Modified residue (large scale data)114PRIDEPhosphoserine
Modified residue118UniProtPhosphothreonine
Modified residue (large scale data)118PRIDEPhosphothreonine
Modified residue122UniProtPhosphoserine
Modified residue (large scale data)122PRIDEPhosphoserine
Modified residue126UniProtPhosphoserine
Modified residue (large scale data)126PRIDEPhosphoserine
Modified residue156UniProtPhosphoserine
Modified residue (large scale data)156PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Ubiquitous.

Gene expression databases

Organism-specific databases

Interaction

Complex viewer

View interactors in UniProtKB
View CPX-1195 in Complex Portal

Protein-protein interaction databases

    • CPX-1195Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex
    • CPX-4084GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant
    • CPX-4203GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA2 variant
    • CPX-4206GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant
    • CPX-4207GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA4 variant

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region49-217Disordered
Compositional bias51-79Basic and acidic residues
Compositional bias92-116Polar residues
Compositional bias117-137Pro residues

Sequence similarities

Belongs to the BCL7 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8WUZ0-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    217
  • Mass (Da)
    23,468
  • Last updated
    2010-05-18 v3
  • Checksum
    379CDFFF250195A5
MAGRTVRAETRSRAKDDIKKVMATIEKVRRWEKRWVTVGDTSLRIFKWVPVVDPQEEERRRAGGGAERSRGRERRGRGASPRGGGPLILLDLNDENSNQSFHSEGSLQKGTEPSPGGTPQPSRPVSPAGPPEGVPEEAQPPRLGQERDPGGITAGSTDEPPMLTKEEPVPELLEAEAPEAYPVFEPVPPVPEAAQGDTEDSEGAPPLKRICPNAPDP

Q8WUZ0-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 177-217: APEAYPVFEPVPPVPEAAQGDTEDSEGAPPLKRICPNAPDP → DSGVRMTRRALHEKGLKTEPLRRLLPRRGLRTNVRPSSMAVPDTRAPGGGSKAPRAPRTIPQGKGR

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
I3L4D5I3L4D5_HUMANBCL7C104
I3L1Q2I3L1Q2_HUMANBCL7C293

Features

Showing features for compositional bias, sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Compositional bias51-79Basic and acidic residues
Compositional bias92-116Polar residues
Sequence conflict108in Ref. 1; CAA11754
Compositional bias117-137Pro residues
Alternative sequenceVSP_019282177-217in isoform 2
Sequence conflict202in Ref. 1; CAA11754

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ223980
EMBL· GenBank· DDBJ
CAA11754.1
EMBL· GenBank· DDBJ
mRNA
AC135048
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC019071
EMBL· GenBank· DDBJ
AAH19071.1
EMBL· GenBank· DDBJ
mRNA
BC058863
EMBL· GenBank· DDBJ
AAH58863.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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