Q8WTT0 · CLC4C_HUMAN

  • Protein
    C-type lectin domain family 4 member C
  • Gene
    CLEC4C
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448).
Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448).
Binds to serum IgG (PubMed:25995448).
Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283).
May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719).
May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283).

Features

Showing features for binding site.

121320406080100120140160180200
TypeIDPosition(s)Description
Binding site139a carbohydrate (UniProtKB | ChEBI)
Binding site172Ca2+ (UniProtKB | ChEBI)
Binding site174Ca2+ (UniProtKB | ChEBI)
Binding site178a carbohydrate (UniProtKB | ChEBI)
Binding site178Ca2+ (UniProtKB | ChEBI)
Binding site184-186a carbohydrate (UniProtKB | ChEBI)
Binding site194a carbohydrate (UniProtKB | ChEBI)
Binding site194Ca2+ (UniProtKB | ChEBI)
Binding site194-195a carbohydrate (UniProtKB | ChEBI)
Binding site195Ca2+ (UniProtKB | ChEBI)
Binding site202a carbohydrate (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular Componentficolin-1-rich granule membrane
Cellular Componentplasma membrane
Cellular Componentsecretory granule membrane
Cellular Componenttertiary granule membrane
Molecular Functioncarbohydrate binding
Molecular Functionmetal ion binding
Biological Processadaptive immune response
Biological Processantifungal innate immune response

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    C-type lectin domain family 4 member C
  • Alternative names
    • Blood dendritic cell antigen 2 (BDCA-2)
    • C-type lectin superfamily member 7
    • Dendritic lectin
  • CD Antigen Name
    • CD303

Gene names

    • Name
      CLEC4C
    • Synonyms
      BDCA2, CLECSF11, CLECSF7, DLEC, HECL
    • ORF names
      UNQ9361/PRO34150

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8WTT0
  • Secondary accessions
    • D3DUU3
    • Q3T1C3
    • Q6UXS8
    • Q8WXX8

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-21Cytoplasmic
Transmembrane22-44Helical; Signal-anchor for type II membrane protein
Topological domain45-213Extracellular

Keywords

Disease & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis139Significantly impairs carbohydrate binding for the trisaccharide Gal(beta1-3/4)GlcNAc(beta1-2)Man.
Mutagenesis184Abolishes carbohydrate binding for the trisaccharide Gal(beta1-3/4)GlcNAc(beta1-2)Man.
Mutagenesis186Significantly impairs carbohydrate binding for the trisaccharide Gal(beta1-3/4)GlcNAc(beta1-2)Man.
Mutagenesis200Significantly impairs carbohydrate binding for the trisaccharide Gal(beta1-3/4)GlcNAc(beta1-2)Man.
Mutagenesis202Significantly impairs carbohydrate binding for the trisaccharide Gal(beta1-3/4)GlcNAc(beta1-2)Man.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 299 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00000466151-213C-type lectin domain family 4 member C
Disulfide bond70↔82
Disulfide bond83↔94
Glycosylation110N-linked (GlcNAc...) asparagine
Disulfide bond111↔206
Glycosylation137N-linked (GlcNAc...) asparagine
Glycosylation164N-linked (GlcNAc...) asparagine
Disulfide bond180↔198

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Homodimer.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q8WTT0CLDN22 Q8N7P33EBI-12913226, EBI-17766761
BINARY Q8WTT0KTN1 Q86UP2-33EBI-12913226, EBI-12007212
BINARY Q8WTT0MAL P211454EBI-12913226, EBI-3932027

Protein-protein interaction databases

Chemistry

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain90-207C-type lectin

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8WTT0-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    213
  • Mass (Da)
    25,038
  • Last updated
    2002-03-01 v1
  • Checksum
    5DC82C95BE2378C1
MVPEEEPQDREKGLWWFQLKVWSMAVVSILLLSVCFTVSSVVPHNFMYSKTVKRLSKLREYQQYHPSLTCVMEGKDIEDWSCCPTPWTSFQSSCYFISTGMQSWTKSQKNCSVMGADLVVINTREEQDFIIQNLKRNSSYFLGLSDPGGRRHWQWVDQTPYNENVTFWHSGEPNNLDERCAIINFRSSEEWGWNDIHCHVPQKSICKMKKIYI

Q8WTT0-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0YGB2H0YGB2_HUMANCLEC4C138
H0YFH6H0YFH6_HUMANCLEC4C88

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_01284511-41in isoform 2
Sequence conflict66in Ref. 3; AAQ88590

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF325459
EMBL· GenBank· DDBJ
AAL37358.1
EMBL· GenBank· DDBJ
mRNA
AF325460
EMBL· GenBank· DDBJ
AAL37359.1
EMBL· GenBank· DDBJ
mRNA
AF293615
EMBL· GenBank· DDBJ
AAL37036.1
EMBL· GenBank· DDBJ
mRNA
AY358223
EMBL· GenBank· DDBJ
AAQ88590.1
EMBL· GenBank· DDBJ
mRNA
CH471116
EMBL· GenBank· DDBJ
EAW88655.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471116
EMBL· GenBank· DDBJ
EAW88656.1
EMBL· GenBank· DDBJ
Genomic DNA
BC074967
EMBL· GenBank· DDBJ
AAH74967.1
EMBL· GenBank· DDBJ
mRNA
BC074968
EMBL· GenBank· DDBJ
AAH74968.1
EMBL· GenBank· DDBJ
mRNA
BC102015
EMBL· GenBank· DDBJ
AAI02016.1
EMBL· GenBank· DDBJ
mRNA
BC102016
EMBL· GenBank· DDBJ
AAI02017.1
EMBL· GenBank· DDBJ
mRNA
BC102017
EMBL· GenBank· DDBJ
AAI02018.1
EMBL· GenBank· DDBJ
mRNA
BC114338
EMBL· GenBank· DDBJ
AAI14339.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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