Q8WPU1 · ESAG6_TRYBB
- ProteinTransferrin receptor subunit ESAG6
- GeneESAG6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids399 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transferrin receptor subunit involved in receptor-mediated acquisition of iron from the environment by binding host TF/transferrin.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | ciliary pocket | |
Cellular Component | plasma membrane | |
Cellular Component | side of membrane | |
Molecular Function | transferrin receptor activity | |
Biological Process | evasion of host immune response |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameTransferrin receptor subunit ESAG6
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma
Accessions
- Primary accessionQ8WPU1
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Lipid-anchor, GPI-anchor
Note: Upon host TF/transferrin binding, the complex formed by ESAG6-ESAG7-TF is endocytosed and delivered to the lysosome where iron is released and host TF is degraded. ESAG6-ESAG7 are then recycled back to the flagellar pocket membrane (PubMed:7957316, PubMed:8522581).
May also be secreted (PubMed:7957316).
May also be secreted (PubMed:7957316).
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond, lipidation, propeptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-17 | |||||
Sequence: MRFWFVLLALLGKEIYA | ||||||
Chain | PRO_5004316049 | 18-376 | Transferrin receptor subunit ESAG6 | |||
Sequence: YENERNALNATAANKVCGLSTYLKGIAHRVNSESAVVTEKLSDLKMRSIQLQLSVMRNRVPSGEQDCKDIRTLLKTVLRNEFTFQQELEEMRNASALAAAAAGLAAGRLEEWIFVFAQAAGRSSQFCISVGKTGPAEYNNLQECFDGTIGPETLYKIEDSRVKESAKTSLQLHEVLSSISFGSLGVKNIRGGNGKDGCNLVRTDTDGVLEGGSPTRHNLTWGGGVMNFGSYQNGSMYVEGGEYGDATEYGAVRWTEDPSKVSIFKDVIRLFARFQEAKNAVVKKIKTTVDELTKCIGQKEAELTNDQLYEEFIWETINRLELSKRVSEQSAFGEEEETIVKFNYTAEPVRGPFTVAGAN | ||||||
Glycosylation | 26 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 34↔161 | |||||
Sequence: CGLSTYLKGIAHRVNSESAVVTEKLSDLKMRSIQLQLSVMRNRVPSGEQDCKDIRTLLKTVLRNEFTFQQELEEMRNASALAAAAAGLAAGRLEEWIFVFAQAAGRSSQFCISVGKTGPAEYNNLQEC | ||||||
Disulfide bond | 84↔312 | |||||
Sequence: CKDIRTLLKTVLRNEFTFQQELEEMRNASALAAAAAGLAAGRLEEWIFVFAQAAGRSSQFCISVGKTGPAEYNNLQECFDGTIGPETLYKIEDSRVKESAKTSLQLHEVLSSISFGSLGVKNIRGGNGKDGCNLVRTDTDGVLEGGSPTRHNLTWGGGVMNFGSYQNGSMYVEGGEYGDATEYGAVRWTEDPSKVSIFKDVIRLFARFQEAKNAVVKKIKTTVDELTKC | ||||||
Glycosylation | 110 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 144↔215 | |||||
Sequence: CISVGKTGPAEYNNLQECFDGTIGPETLYKIEDSRVKESAKTSLQLHEVLSSISFGSLGVKNIRGGNGKDGC | ||||||
Glycosylation | 235 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 250 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 360 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Lipidation | 376 | GPI-anchor amidated asparagine | ||||
Sequence: N | ||||||
Propeptide | PRO_0000458751 | 377-399 | Removed in mature form | |||
Sequence: AAAIHLSVSTAALCRSALLLGVL |
Post-translational modification
N-glycosylated (PubMed:18680745, PubMed:7957316, PubMed:8522581).
Glycosylation is dispensable for heterodimer formation and host transferrin binding (PubMed:18680745).
Glycosylation is dispensable for heterodimer formation and host transferrin binding (PubMed:18680745).
Keywords
- PTM
PTM databases
Expression
Induction
Up-regulated by low iron levels.
Developmental stage
Expressed in the bloodstream form (at protein level).
Interaction
Subunit
Heterodimer composed of ESAG6 and ESAG7.
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length399
- Mass (Da)43,850
- Last updated2002-03-01 v1
- Checksum76B5258209CAD126
Polymorphism
There are about 20 variants for ESAG6. ESAG6 is one of the expression site-associated genes (ESAGs) which, together with the variable surface glycoprotein (VSG) gene, are part of polycistronic transcriptional units known as the bloodstream-form expression sites (BESs) (PubMed:12106867).
The number of BES is strain-dependent and only a single BES is expressed at any given time (PubMed:12106867).
This monoallelic expression is responsible for the parasite's evasion of the host immune response by antigenic variation (PubMed:12106867).
This entry is encoded by the BES17 locus and can bind transferrin from human, cow, goat, horse, rat, mouse, pig and rabbit (PubMed:12106867, PubMed:31636418).
The number of BES is strain-dependent and only a single BES is expressed at any given time (PubMed:12106867).
This monoallelic expression is responsible for the parasite's evasion of the host immune response by antigenic variation (PubMed:12106867).
This entry is encoded by the BES17 locus and can bind transferrin from human, cow, goat, horse, rat, mouse, pig and rabbit (PubMed:12106867, PubMed:31636418).
Keywords
- Technical term