Q8WPU1 · ESAG6_TRYBB

  • Protein
    Transferrin receptor subunit ESAG6
  • Gene
    ESAG6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transferrin receptor subunit involved in receptor-mediated acquisition of iron from the environment by binding host TF/transferrin.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentciliary pocket
Cellular Componentplasma membrane
Cellular Componentside of membrane
Molecular Functiontransferrin receptor activity
Biological Processevasion of host immune response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transferrin receptor subunit ESAG6
  • Alternative names
    • Expression site associated gene 6

Gene names

    • Name
      ESAG6
    • Synonyms
      13J3.10

Organism names

  • Taxonomic identifier
  • Strain
    • 427
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma

Accessions

  • Primary accession
    Q8WPU1

Organism-specific databases

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor
Flagellar pocket
Note: Upon host TF/transferrin binding, the complex formed by ESAG6-ESAG7-TF is endocytosed and delivered to the lysosome where iron is released and host TF is degraded. ESAG6-ESAG7 are then recycled back to the flagellar pocket membrane (PubMed:7957316, PubMed:8522581).
May also be secreted (PubMed:7957316).

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond, lipidation, propeptide.

TypeIDPosition(s)Description
Signal1-17
ChainPRO_500431604918-376Transferrin receptor subunit ESAG6
Glycosylation26N-linked (GlcNAc...) asparagine
Disulfide bond34↔161
Disulfide bond84↔312
Glycosylation110N-linked (GlcNAc...) asparagine
Disulfide bond144↔215
Glycosylation235N-linked (GlcNAc...) asparagine
Glycosylation250N-linked (GlcNAc...) asparagine
Glycosylation360N-linked (GlcNAc...) asparagine
Lipidation376GPI-anchor amidated asparagine
PropeptidePRO_0000458751377-399Removed in mature form

Post-translational modification

N-glycosylated (PubMed:18680745, PubMed:7957316, PubMed:8522581).
Glycosylation is dispensable for heterodimer formation and host transferrin binding (PubMed:18680745).

Keywords

PTM databases

Expression

Induction

Up-regulated by low iron levels.

Developmental stage

Expressed in the bloodstream form (at protein level).

Interaction

Subunit

Heterodimer composed of ESAG6 and ESAG7.

Family & Domains

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    399
  • Mass (Da)
    43,850
  • Last updated
    2002-03-01 v1
  • Checksum
    76B5258209CAD126
MRFWFVLLALLGKEIYAYENERNALNATAANKVCGLSTYLKGIAHRVNSESAVVTEKLSDLKMRSIQLQLSVMRNRVPSGEQDCKDIRTLLKTVLRNEFTFQQELEEMRNASALAAAAAGLAAGRLEEWIFVFAQAAGRSSQFCISVGKTGPAEYNNLQECFDGTIGPETLYKIEDSRVKESAKTSLQLHEVLSSISFGSLGVKNIRGGNGKDGCNLVRTDTDGVLEGGSPTRHNLTWGGGVMNFGSYQNGSMYVEGGEYGDATEYGAVRWTEDPSKVSIFKDVIRLFARFQEAKNAVVKKIKTTVDELTKCIGQKEAELTNDQLYEEFIWETINRLELSKRVSEQSAFGEEEETIVKFNYTAEPVRGPFTVAGANAAAIHLSVSTAALCRSALLLGVL

Polymorphism

There are about 20 variants for ESAG6. ESAG6 is one of the expression site-associated genes (ESAGs) which, together with the variable surface glycoprotein (VSG) gene, are part of polycistronic transcriptional units known as the bloodstream-form expression sites (BESs) (PubMed:12106867).
The number of BES is strain-dependent and only a single BES is expressed at any given time (PubMed:12106867).
This monoallelic expression is responsible for the parasite's evasion of the host immune response by antigenic variation (PubMed:12106867).
This entry is encoded by the BES17 locus and can bind transferrin from human, cow, goat, horse, rat, mouse, pig and rabbit (PubMed:12106867, PubMed:31636418).

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL670322
EMBL· GenBank· DDBJ
CAD21457.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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