Q8WPI2 · KUNIH_RHIMP

Function

function

Midgut thrombin inhibitor that plays a major role in keeping the midgut microenvironment at low hemostatic and inflammatory tonus (By similarity) (PubMed:18286181).
Also inhibits FXIa (F11), kallikrein (KLK1), neutrophil elastase (ELANE) and cathepsin G (CTSG), which play a role in the contact pathway of the coagulation cascade (By similarity) (PubMed:18286181).
Also abrogates platelet aggregation by cathepsin G and plasmin, and attenuates tissue factor (F3) pathway inhibitor cleavage by elastase (By similarity) (PubMed:18286181).
In vivo, inhibits thrombosis and promotes bleeding in mice (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functionserine-type endopeptidase inhibitor activity
Molecular Functiontoxin activity
Biological Processenvenomation resulting in negative regulation of voltage-gated potassium channel activity in another organism

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Boophilin-H2

Organism names

Accessions

  • Primary accession
    Q8WPI2

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, modified residue, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-15
Modified residue16Pyrrolidone carboxylic acid
ChainPRO_500006699316-142Boophilin-H2
Disulfide bond21↔71
Disulfide bond30↔54
Disulfide bond46↔67
Disulfide bond89↔139
Disulfide bond98↔122
Disulfide bond114↔135

Post-translational modification

The N-terminus is blocked.

Keywords

Expression

Tissue specificity

Expressed in the midgut.

Interaction

Subunit

Interacts with host thrombin and trypsin.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-71BPTI/Kunitz inhibitor 1
Domain89-139BPTI/Kunitz inhibitor 2

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    142
  • Mass (Da)
    15,538
  • Last updated
    2002-03-01 v1
  • MD5 Checksum
    6375EC4BC1A2F76C3F66D4B625C7EFB7
MKCIILLAVLGTAFAQRNGFCRLPADEGICKALIPRFYFNTETGKCTMFSYGGCGGNENNFETIEECQKACGAPERVNDFESADFKTGCEPAADSGSCAGQLERWFYNVQSGECETFVYGGCGGNDNNYESEEECELVCKNM

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ304447
EMBL· GenBank· DDBJ
CAC82583.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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