Q8WNU8 · NEK11_MACFA
- ProteinSerine/threonine-protein kinase Nek11
- GeneNEK11
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids637 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )
Activity regulation
Autorepressed by intramolecular binding of the C-terminus which dissociates following phosphorylation by NEK2. Activated in response to DNA damage. Inhibited by zinc.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleolus | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | intracellular signal transduction | |
Biological Process | mitotic intra-S DNA damage checkpoint signaling | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase Nek11
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionQ8WNU8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S-arrested cells.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000086439 | 1-637 | Serine/threonine-protein kinase Nek11 | |||
Sequence: MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDYKIQEYKEAGKIFPDNQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNTIMESMLNKNPSLRPSAIEILKIPYIDEQLQHLMCRHSEMTLEDKNLDCQKEAARLINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADERARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLIGMEEKEEQPEGRPSCSPQDEDEERWQDREEEFDEPTLENLSEPQPIPSMDLRKLESIVEDATSDLGYHEIPEDPLVAEEYYADAFDSYCEESDEEEEEIVLAGPEKEIKNEGSQPTYRTNQQDSDIEALARCLENVLGCTSLDTKTIPSMAADVSPGPTIFNSVMARTKMKRMRESAMQKLGTEVFEEVYNYLKRARHQNASEAEIRERLEKVVPRASDCFEVDQLLYFEEQLLITMGK | ||||||
Modified residue | 273 | Phosphoserine; by CHEK1 | ||||
Sequence: S |
Post-translational modification
Phosphorylated by NEK2. Phosphorylation at Ser-273 is important for its activation.
Keywords
- PTM
Interaction
Structure
Family & Domains
Features
Showing features for domain, coiled coil, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 29-287 | Protein kinase | ||||
Sequence: YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDYKIQEYKEAGKIFPDNQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNTIMESMLNKNPSLRPSAIEILKIPYI | ||||||
Coiled coil | 302-385 | |||||
Sequence: TLEDKNLDCQKEAARLINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADERARKLKKIVEEKYEENSKRMQELRSRNFQQ | ||||||
Compositional bias | 399-420 | Basic and acidic residues | ||||
Sequence: GMEEKEEQPEGRPSCSPQDEDE | ||||||
Region | 399-446 | Disordered | ||||
Sequence: GMEEKEEQPEGRPSCSPQDEDEERWQDREEEFDEPTLENLSEPQPIPS | ||||||
Compositional bias | 421-435 | Acidic residues | ||||
Sequence: ERWQDREEEFDEPTL |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length637
- Mass (Da)73,337
- Last updated2002-03-01 v1
- ChecksumFA3A5C3CEE5AD16F
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 399-420 | Basic and acidic residues | ||||
Sequence: GMEEKEEQPEGRPSCSPQDEDE | ||||||
Compositional bias | 421-435 | Acidic residues | ||||
Sequence: ERWQDREEEFDEPTL |
Keywords
- Technical term