Q8W8U1 · Q8W8U1_HUMAN

  • Protein
    NADH-ubiquinone oxidoreductase chain 5
  • Gene
    ND5
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological ProcessATP synthesis coupled electron transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 5
  • EC number

Gene names

    • Name
      ND5
    • Synonyms
      NADH5

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CA2_B2al
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8W8U1

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane84-105Helical
Transmembrane117-134Helical
Transmembrane140-160Helical
Transmembrane172-191Helical
Transmembrane211-233Helical
Transmembrane245-266Helical
Transmembrane272-294Helical
Transmembrane301-319Helical
Transmembrane325-347Helical
Transmembrane368-386Helical
Transmembrane406-433Helical
Transmembrane454-472Helical
Transmembrane484-507Helical
Transmembrane584-602Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_501509945922-603NADH-ubiquinone oxidoreductase chain 5

Proteomic databases

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain68-118NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Domain134-419NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Domain422-602NADH dehydrogenase subunit 5 C-terminal

Sequence similarities

Belongs to the complex I subunit 5 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    603
  • Mass (Da)
    67,057
  • Last updated
    2002-03-01 v1
  • Checksum
    35BF401AABC9010D
MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSIMHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF381982
EMBL· GenBank· DDBJ
AAL54407.1
EMBL· GenBank· DDBJ
Genomic DNA
AF381983
EMBL· GenBank· DDBJ
AAL54420.1
EMBL· GenBank· DDBJ
Genomic DNA
AY714010
EMBL· GenBank· DDBJ
AAU02576.1
EMBL· GenBank· DDBJ
Genomic DNA
AY882383
EMBL· GenBank· DDBJ
AAW58213.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ112836
EMBL· GenBank· DDBJ
AAZ01746.1
EMBL· GenBank· DDBJ
Genomic DNA
EF657252
EMBL· GenBank· DDBJ
ABR93254.1
EMBL· GenBank· DDBJ
Genomic DNA
EU092765
EMBL· GenBank· DDBJ
ABU65373.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ348224
EMBL· GenBank· DDBJ
ACJ60488.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383256
EMBL· GenBank· DDBJ
ACM70464.1
EMBL· GenBank· DDBJ
Genomic DNA
GU122986
EMBL· GenBank· DDBJ
ACY55228.1
EMBL· GenBank· DDBJ
Genomic DNA
HM625682
EMBL· GenBank· DDBJ
ADK77230.1
EMBL· GenBank· DDBJ
Genomic DNA
HM852891
EMBL· GenBank· DDBJ
ADL31659.1
EMBL· GenBank· DDBJ
Genomic DNA
GU733757
EMBL· GenBank· DDBJ
ADP22865.1
EMBL· GenBank· DDBJ
Genomic DNA
JN858956
EMBL· GenBank· DDBJ
AET08398.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ664533
EMBL· GenBank· DDBJ
AFC97983.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702677
EMBL· GenBank· DDBJ
AFF72769.1
EMBL· GenBank· DDBJ
Genomic DNA
JX120739
EMBL· GenBank· DDBJ
AFN05588.1
EMBL· GenBank· DDBJ
Genomic DNA
JX152854
EMBL· GenBank· DDBJ
AFO21285.1
EMBL· GenBank· DDBJ
Genomic DNA
KC622074
EMBL· GenBank· DDBJ
AGJ95444.1
EMBL· GenBank· DDBJ
Genomic DNA
KC993948
EMBL· GenBank· DDBJ
AGO22319.1
EMBL· GenBank· DDBJ
Genomic DNA
KC911314
EMBL· GenBank· DDBJ
AGO90832.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451722
EMBL· GenBank· DDBJ
AGZ76029.1
EMBL· GenBank· DDBJ
Genomic DNA
KF849970
EMBL· GenBank· DDBJ
AHE79508.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ185459
EMBL· GenBank· DDBJ
AID08386.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ856754
EMBL· GenBank· DDBJ
AIN38305.1
EMBL· GenBank· DDBJ
Genomic DNA
KR135841
EMBL· GenBank· DDBJ
AKT94135.1
EMBL· GenBank· DDBJ
Genomic DNA
KT819242
EMBL· GenBank· DDBJ
ALM03703.1
EMBL· GenBank· DDBJ
Genomic DNA
KX457213
EMBL· GenBank· DDBJ
APD62808.1
EMBL· GenBank· DDBJ
Genomic DNA
KX675305
EMBL· GenBank· DDBJ
APZ83671.1
EMBL· GenBank· DDBJ
Genomic DNA
KY408221
EMBL· GenBank· DDBJ
AQU16293.1
EMBL· GenBank· DDBJ
Genomic DNA
KY595612
EMBL· GenBank· DDBJ
ARD72590.1
EMBL· GenBank· DDBJ
Genomic DNA
KY411455
EMBL· GenBank· DDBJ
ARM19101.1
EMBL· GenBank· DDBJ
Genomic DNA
MF362799
EMBL· GenBank· DDBJ
ASF85091.1
EMBL· GenBank· DDBJ
Genomic DNA
MF362927
EMBL· GenBank· DDBJ
ASF86755.1
EMBL· GenBank· DDBJ
Genomic DNA
MF056494
EMBL· GenBank· DDBJ
ASS03359.1
EMBL· GenBank· DDBJ
Genomic DNA
KY680798
EMBL· GenBank· DDBJ
ASZ80473.1
EMBL· GenBank· DDBJ
Genomic DNA
MF621089
EMBL· GenBank· DDBJ
ATP05160.1
EMBL· GenBank· DDBJ
Genomic DNA
KY797181
EMBL· GenBank· DDBJ
AUG82499.1
EMBL· GenBank· DDBJ
Genomic DNA
MG272781
EMBL· GenBank· DDBJ
AVL87583.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449386
EMBL· GenBank· DDBJ
AYW09737.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008550
EMBL· GenBank· DDBJ
BAE11145.1
EMBL· GenBank· DDBJ
Genomic DNA
AP009461
EMBL· GenBank· DDBJ
BAG39263.1
EMBL· GenBank· DDBJ
Genomic DNA
MK321335
EMBL· GenBank· DDBJ
QAV57409.1
EMBL· GenBank· DDBJ
Genomic DNA
MK059689
EMBL· GenBank· DDBJ
QCB19175.1
EMBL· GenBank· DDBJ
Genomic DNA
MK491358
EMBL· GenBank· DDBJ
QEG55102.1
EMBL· GenBank· DDBJ
Genomic DNA
MN503424
EMBL· GenBank· DDBJ
QEW88697.1
EMBL· GenBank· DDBJ
Genomic DNA
MT079095
EMBL· GenBank· DDBJ
QIV22201.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849781
EMBL· GenBank· DDBJ
QKT25697.1
EMBL· GenBank· DDBJ
Genomic DNA
MW886126
EMBL· GenBank· DDBJ
QUL59211.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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