Q8W8U1 · Q8W8U1_HUMAN
- ProteinNADH-ubiquinone oxidoreductase chain 5
- GeneND5
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids603 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Biological Process | ATP synthesis coupled electron transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 5
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8W8U1
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 84-105 | Helical | ||||
Sequence: YFSMMFIPVALFVTWSIMEFSL | ||||||
Transmembrane | 117-134 | Helical | ||||
Sequence: FFKYLLIFLITMLILVTA | ||||||
Transmembrane | 140-160 | Helical | ||||
Sequence: LFIGWEGVGIMSFLLISWWYA | ||||||
Transmembrane | 172-191 | Helical | ||||
Sequence: ILYNRIGDIGFILALAWFIL | ||||||
Transmembrane | 211-233 | Helical | ||||
Sequence: TPLLGLLLAAAGKSAQLGLHPWL | ||||||
Transmembrane | 245-266 | Helical | ||||
Sequence: ALLHSSTMVVAGIFLLIRFHPL | ||||||
Transmembrane | 272-294 | Helical | ||||
Sequence: LIQTLTLCLGAITTLFAAVCALT | ||||||
Transmembrane | 301-319 | Helical | ||||
Sequence: IVAFSTSSQLGLMMVTIGI | ||||||
Transmembrane | 325-347 | Helical | ||||
Sequence: AFLHICTHAFFKAMLFMCSGSII | ||||||
Transmembrane | 368-386 | Helical | ||||
Sequence: LTSTSLTIGSLALAGMPFL | ||||||
Transmembrane | 406-433 | Helical | ||||
Sequence: AWALSITLIATSLTSAYSTRMILLTLTG | ||||||
Transmembrane | 454-472 | Helical | ||||
Sequence: IKRLAAGSLFAGFLITNNI | ||||||
Transmembrane | 484-507 | Helical | ||||
Sequence: LYLKLTALAVTFLGLLTALDLNYL | ||||||
Transmembrane | 584-602 | Helical | ||||
Sequence: IKLYFLSFFFPLILTLLLI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MTMHTTMTTLTLTSLIPPILT | ||||||
Chain | PRO_5015099459 | 22-603 | NADH-ubiquinone oxidoreductase chain 5 | |||
Sequence: TLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSIMHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT |
Proteomic databases
Interaction
Subunit
Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 68-118 | NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal | ||||
Sequence: WATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFF | ||||||
Domain | 134-419 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: ANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLT | ||||||
Domain | 422-602 | NADH dehydrogenase subunit 5 C-terminal | ||||
Sequence: YSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSIMHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLI |
Sequence similarities
Belongs to the complex I subunit 5 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length603
- Mass (Da)67,057
- Last updated2002-03-01 v1
- Checksum35BF401AABC9010D
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF381982 EMBL· GenBank· DDBJ | AAL54407.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF381983 EMBL· GenBank· DDBJ | AAL54420.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY714010 EMBL· GenBank· DDBJ | AAU02576.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY882383 EMBL· GenBank· DDBJ | AAW58213.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ112836 EMBL· GenBank· DDBJ | AAZ01746.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF657252 EMBL· GenBank· DDBJ | ABR93254.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU092765 EMBL· GenBank· DDBJ | ABU65373.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ348224 EMBL· GenBank· DDBJ | ACJ60488.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383256 EMBL· GenBank· DDBJ | ACM70464.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU122986 EMBL· GenBank· DDBJ | ACY55228.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM625682 EMBL· GenBank· DDBJ | ADK77230.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM852891 EMBL· GenBank· DDBJ | ADL31659.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU733757 EMBL· GenBank· DDBJ | ADP22865.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN858956 EMBL· GenBank· DDBJ | AET08398.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ664533 EMBL· GenBank· DDBJ | AFC97983.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702677 EMBL· GenBank· DDBJ | AFF72769.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX120739 EMBL· GenBank· DDBJ | AFN05588.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX152854 EMBL· GenBank· DDBJ | AFO21285.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC622074 EMBL· GenBank· DDBJ | AGJ95444.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC993948 EMBL· GenBank· DDBJ | AGO22319.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC911314 EMBL· GenBank· DDBJ | AGO90832.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451722 EMBL· GenBank· DDBJ | AGZ76029.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF849970 EMBL· GenBank· DDBJ | AHE79508.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ185459 EMBL· GenBank· DDBJ | AID08386.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ856754 EMBL· GenBank· DDBJ | AIN38305.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR135841 EMBL· GenBank· DDBJ | AKT94135.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT819242 EMBL· GenBank· DDBJ | ALM03703.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX457213 EMBL· GenBank· DDBJ | APD62808.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX675305 EMBL· GenBank· DDBJ | APZ83671.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY408221 EMBL· GenBank· DDBJ | AQU16293.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY595612 EMBL· GenBank· DDBJ | ARD72590.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY411455 EMBL· GenBank· DDBJ | ARM19101.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF362799 EMBL· GenBank· DDBJ | ASF85091.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF362927 EMBL· GenBank· DDBJ | ASF86755.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF056494 EMBL· GenBank· DDBJ | ASS03359.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY680798 EMBL· GenBank· DDBJ | ASZ80473.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF621089 EMBL· GenBank· DDBJ | ATP05160.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY797181 EMBL· GenBank· DDBJ | AUG82499.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG272781 EMBL· GenBank· DDBJ | AVL87583.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449386 EMBL· GenBank· DDBJ | AYW09737.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008550 EMBL· GenBank· DDBJ | BAE11145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009461 EMBL· GenBank· DDBJ | BAG39263.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK321335 EMBL· GenBank· DDBJ | QAV57409.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK059689 EMBL· GenBank· DDBJ | QCB19175.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK491358 EMBL· GenBank· DDBJ | QEG55102.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN503424 EMBL· GenBank· DDBJ | QEW88697.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT079095 EMBL· GenBank· DDBJ | QIV22201.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN849781 EMBL· GenBank· DDBJ | QKT25697.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW886126 EMBL· GenBank· DDBJ | QUL59211.1 EMBL· GenBank· DDBJ | Genomic DNA |