Q8W4P8 · MEB1_ARATH

Function

function

May sequester excess cytosolic iron and manganese into endoplasmic reticulum to reduce metal ion toxicity. Not essential for the accumulation of ER body components, including PYK10.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentER body
Molecular Functioniron ion transmembrane transporter activity
Molecular Functionmanganese ion transmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Membrane protein of ER body 1

Gene names

    • Name
      MEB1
    • ORF names
      T27E11.100
    • Ordered locus names
      At4g27860

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q8W4P8
  • Secondary accessions
    • C0Z3G6
    • F4JJT0
    • Q9STP0

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Note: Located in ER bodies.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane209-229Helical; Name=1
Transmembrane250-270Helical; Name=2
Transmembrane508-528Helical; Name=3
Transmembrane540-560Helical; Name=4

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype and no effect on pathogen sensitivity.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 67 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004304671-611Membrane protein of ER body 1

Proteomic databases

PTM databases

Expression

Induction

Induced by NAI1.

Gene expression databases

Interaction

Subunit

Interacts directly or indirectly with NAI2.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-71Disordered
Compositional bias7-24Polar residues
Compositional bias45-70Polar residues
Compositional bias127-147Basic and acidic residues
Region127-149Disordered
Compositional bias283-317Basic and acidic residues
Region283-375Disordered
Compositional bias318-334Polar residues
Compositional bias335-361Basic and acidic residues
Compositional bias387-402Polar residues
Region387-406Disordered
Region470-492Disordered

Sequence similarities

Belongs to the CCC1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q8W4P8-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    611
  • Mass (Da)
    68,170
  • Last updated
    2002-03-01 v1
  • Checksum
    7E154E953D9DCFCD
MDPTMNPTPTPSSAGNSVCTDELTNLPPEDSPLDSEKDDSVDFSQEQGSESNEAIDTENGSRSVDKNQYSETEVVVRAKDLQTEPDSLDDDVEIVIKNQHKYYIYCPCCGEDITKTVKLVKISDPKHTKDHDKAVDSDTENGSKSKDKNTKVPSWFSDFIQPLFSSEDRGKKGVVDSELLGTYEDLGIIGEEPSIDVSNEKDRPSFPKWYLDVFAWLFLCIIIALSVLSTSPPPFIQPHLQLPSMPTLRMPSASVLLLLPTSAVLLLFIISMRSRFTPRYHKEKGEVVPKSTDSKSHDDQAANTDQDFDKKTDNKRNRLTPIYPSSLEKPSKQTVNKETQNHDKEAADPDQDVDKETENQKSHLTPIYPSPLEQPSKQIINKETQTEPMLPPNAQSEIPNSVEPRKGGNKVEILKSIVYGGLTESITSLCTVTSAAASGASTLNVLALGVANLSSGLLLTVHSLQELINEKPRKQTNTDDSPEEGEGEEDRYEEVLGRREYSRIHRVIAISSFVIFGLIPPLVYGFSFRKKMEKRQEYKVLAVYAVSLLCIVLLSIAKAYVSKKRDYVKTLFRYTTTATTASGFSQFVGYLVSQWLEKSGFYDDSPETQRV

Q8W4P8-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q8W4P8-3

  • Name
    3
  • Note
    May be due to an intron retention in isoform 2.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1P8B7C6A0A1P8B7C6_ARATHMEB1619
A0A1P8B7E1A0A1P8B7E1_ARATHMEB1621

Sequence caution

The sequence CAB43974.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence CAB81435.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for alternative sequence, compositional bias.

Type
IDPosition(s)Description
Alternative sequenceVSP_0567601-244in isoform 3
Compositional bias7-24Polar residues
Compositional bias45-70Polar residues
Compositional bias127-147Basic and acidic residues
Compositional bias283-317Basic and acidic residues
Alternative sequenceVSP_056761313-327in isoform 3 and isoform 2
Compositional bias318-334Polar residues
Compositional bias335-361Basic and acidic residues
Compositional bias387-402Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL078579
EMBL· GenBank· DDBJ
CAB43974.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AL161571
EMBL· GenBank· DDBJ
CAB81435.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002687
EMBL· GenBank· DDBJ
AEE85401.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
AEE85402.1
EMBL· GenBank· DDBJ
Genomic DNA
AY062118
EMBL· GenBank· DDBJ
AAL32990.1
EMBL· GenBank· DDBJ
mRNA
BT010175
EMBL· GenBank· DDBJ
AAQ22644.1
EMBL· GenBank· DDBJ
mRNA
AK319130
EMBL· GenBank· DDBJ
BAH57245.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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