Q8W4P8 · MEB1_ARATH
- ProteinMembrane protein of ER body 1
- GeneMEB1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids611 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May sequester excess cytosolic iron and manganese into endoplasmic reticulum to reduce metal ion toxicity. Not essential for the accumulation of ER body components, including PYK10.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | ER body | |
Molecular Function | iron ion transmembrane transporter activity | |
Molecular Function | manganese ion transmembrane transporter activity |
Names & Taxonomy
Protein names
- Recommended nameMembrane protein of ER body 1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ8W4P8
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Note: Located in ER bodies.
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 209-229 | Helical; Name=1 | |||
Transmembrane | 250-270 | Helical; Name=2 | |||
Transmembrane | 508-528 | Helical; Name=3 | |||
Transmembrane | 540-560 | Helical; Name=4 | |||
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
No visible phenotype and no effect on pathogen sensitivity.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 67 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000430467 | 1-611 | Membrane protein of ER body 1 | ||
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-71 | Disordered | |||
Compositional bias | 7-24 | Polar residues | |||
Compositional bias | 45-70 | Polar residues | |||
Compositional bias | 127-147 | Basic and acidic residues | |||
Region | 127-149 | Disordered | |||
Compositional bias | 283-317 | Basic and acidic residues | |||
Region | 283-375 | Disordered | |||
Compositional bias | 318-334 | Polar residues | |||
Compositional bias | 335-361 | Basic and acidic residues | |||
Compositional bias | 387-402 | Polar residues | |||
Region | 387-406 | Disordered | |||
Region | 470-492 | Disordered | |||
Sequence similarities
Belongs to the CCC1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q8W4P8-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length611
- Mass (Da)68,170
- Last updated2002-03-01 v1
- Checksum7E154E953D9DCFCD
Q8W4P8-2
- Name2
- Differences from canonical
- 313-327: Missing
Q8W4P8-3
- Name3
- NoteMay be due to an intron retention in isoform 2.
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8B7C6 | A0A1P8B7C6_ARATH | MEB1 | 619 | ||
A0A1P8B7E1 | A0A1P8B7E1_ARATH | MEB1 | 621 |
Sequence caution
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_056760 | 1-244 | in isoform 3 | ||
Compositional bias | 7-24 | Polar residues | |||
Compositional bias | 45-70 | Polar residues | |||
Compositional bias | 127-147 | Basic and acidic residues | |||
Compositional bias | 283-317 | Basic and acidic residues | |||
Alternative sequence | VSP_056761 | 313-327 | in isoform 3 and isoform 2 | ||
Compositional bias | 318-334 | Polar residues | |||
Compositional bias | 335-361 | Basic and acidic residues | |||
Compositional bias | 387-402 | Polar residues | |||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL078579 EMBL· GenBank· DDBJ | CAB43974.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AL161571 EMBL· GenBank· DDBJ | CAB81435.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002687 EMBL· GenBank· DDBJ | AEE85401.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE85402.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY062118 EMBL· GenBank· DDBJ | AAL32990.1 EMBL· GenBank· DDBJ | mRNA | ||
BT010175 EMBL· GenBank· DDBJ | AAQ22644.1 EMBL· GenBank· DDBJ | mRNA | ||
AK319130 EMBL· GenBank· DDBJ | BAH57245.1 EMBL· GenBank· DDBJ | mRNA |