Q8W104 · FBL17_ARATH

Function

function

Essential protein for male fertility. Component of the SCF(ASK-cullin-F-box) E3 ubiquitin ligase complex SCF(FBL17), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Enables the switch in cell cycle control leading to male germ cell lineage formation from microspores after meiosis. Targets CDKA-1 inhibitors the degradation specifically in male germ cells (e.g. KRP6 and KRP7) and thus enables CDKA-1 activation and germ cell S-phase progression. Promotes twin sperm cell production and double fertilization.

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmale germ cell nucleus
Cellular Componentnucleus
Cellular ComponentSCF ubiquitin ligase complex
Cellular Componentsite of double-strand break
Biological ProcessDNA damage response
Biological Processembryo development ending in seed dormancy
Biological Processgenerative cell mitosis
Biological Processpollen development
Biological Processprotein ubiquitination
Biological Processregulation of cell division
Biological ProcessSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Biological Processseed development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    F-box/LRR-repeat protein 17
  • Alternative names
    • F-box-like protein 17

Gene names

    • Name
      FBL17
    • ORF names
      T5N23.10
    • Ordered locus names
      At3g54650

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q8W104
  • Secondary accessions
    • Q9M1T4

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Nucleus
Note: Confined to the male germ cell nucleus of early to mid bicellular pollen.

Keywords

Phenotypes & Variants

Disruption phenotype

Stabilization of KRP6 and inhibition of germ cell cycle progression leading to male sterility.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 29 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002722571-593F-box/LRR-repeat protein 17

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in developing pollen.

Developmental stage

Expressed transiently in the male germ line after asymmetric division. Present in maturing pollen with highest levels in bicellular pollen.

Gene expression databases

Interaction

Subunit

Part of a SCF (ASK-cullin-F-box) protein ligase complex. Interacts with SKP1A/ASK1, KRP4, KRP6 and KRP7.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q8W104KRP6 Q0WNX93EBI-2026732, EBI-1253171
BINARY Q8W104KRP7 Q94CL94EBI-2026732, EBI-1773344

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, repeat.

TypeIDPosition(s)Description
Domain120-177F-box
Repeat178-206LRR 1
Repeat207-232LRR 2
Repeat237-262LRR 3
Repeat276-304LRR 4
Repeat335-361LRR 5
Repeat362-387LRR 6
Repeat414-439LRR 7
Repeat477-502LRR 8
Repeat503-525LRR 9

Domain

The F-box is necessary for the interaction with ASK proteins.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    593
  • Mass (Da)
    64,769
  • Last updated
    2002-03-01 v1
  • Checksum
    B7C9668303455BB3
MQPQPHISPNTATAAISAALESQRSRKNRGSYNCGRCGQPKKGHVCLLTAPPDIPTTPIASEPVSCISAAASSSRSTVLSLTAAPSSRQTFTHLRRALSFDDVDARNSLDESDLDAASMDLDLQLDTDIVQPGRFHAVGLWEVLKRLPPSSLLMAARVCKGWRETSRKMWKAAEELRIRVPERAQIGYIGSLLQKCPRLIRLSLKIESDFDATTLACIAFSCPNLEVLEITTSGAAVNRISGDELSRFVANKRGLTSLKMEGCSNLGGFSLSSSSLSTLWLSDLHSLSKMIFNCPNLTEISLEFSRQEDDSTDLVTMVDGLGRTCTRLQNIHIASLKLSHTVVLSLTAVNFRYLRMLSLVLGINITDASVAAISSGYKNLELLDLSGSSITDTGLGMICDVLPDTLSKLLVALCPNITSSGIQFATAQLPLLELMDCGMTVSDPNSDNPTFVENPSPHKTPGYNQKMFIKHKRLKKLSLWGCSSLDALFLNCPELMDLNLNLCSNLHPESLVLQCPKLQLVYASGCQGLLTGAIRKQVSENFSAGENHMPRKRLADASKRIQALPSLYQETREDGIYAGKRRKLEKEMCTIIH

Sequence caution

The sequence CAB77585.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL138650
EMBL· GenBank· DDBJ
CAB77585.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002686
EMBL· GenBank· DDBJ
AEE79261.1
EMBL· GenBank· DDBJ
Genomic DNA
AF462827
EMBL· GenBank· DDBJ
AAL58916.1
EMBL· GenBank· DDBJ
mRNA
AY142006
EMBL· GenBank· DDBJ
AAM98270.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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