Q8VYP9 · ICML1_ARATH
- ProteinProbable isoprenylcysteine alpha-carbonyl methylesterase ICMEL1
- GeneICMEL1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids476 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Catalyzes the demethylation of isoprenylcysteine methylesters (By similarity).
May be involved in the regulation of ABA signaling (By similarity).
May be involved in the regulation of ABA signaling (By similarity).
Catalytic activity
- [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + methanol + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 214-216 | substrate | |||
Binding site | 285-287 | substrate | |||
Active site | 286 | ||||
Active site | 388 | ||||
Active site | 420 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | Golgi membrane | |
Molecular Function | prenylcysteine methylesterase activity |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameProbable isoprenylcysteine alpha-carbonyl methylesterase ICMEL1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ8VYP9
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 153-173 | Helical | |||
Transmembrane | 208-228 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000411669 | 1-476 | Probable isoprenylcysteine alpha-carbonyl methylesterase ICMEL1 | ||
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in roots, rosette and cauline leaves, stems, flowers and siliques.
Induction
Down-regulated by heat treatment.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 92-116 | Disordered | |||
Sequence similarities
Belongs to the AB hydrolase superfamily. Isoprenylcysteine methylesterase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q8VYP9-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length476
- Mass (Da)52,719
- Last updated2002-03-01 v1
- Checksum410B5D403A4AD32B
Q8VYP9-2
- Name2
- Differences from canonical
- 327-476: Missing
Sequence caution
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_041624 | 327-476 | in isoform 2 | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC079829 EMBL· GenBank· DDBJ | AAG50668.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AC084221 EMBL· GenBank· DDBJ | AAG50528.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002684 EMBL· GenBank· DDBJ | AEE30651.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY070374 EMBL· GenBank· DDBJ | AAL49871.1 EMBL· GenBank· DDBJ | mRNA | ||
AY091332 EMBL· GenBank· DDBJ | AAM14271.1 EMBL· GenBank· DDBJ | mRNA | ||
AK318861 EMBL· GenBank· DDBJ | BAH56976.1 EMBL· GenBank· DDBJ | mRNA |