Q8VYF7 · WHY2_ARATH

Function

function

Single-stranded DNA-binding protein that associates with mitochondrial DNA and may play a role in the regulation of the gene expression machinery. Seems also to be required to prevent break-induced DNA rearrangements in the mitochondrial genome. Can bind to melt double-stranded DNA in vivo.

Miscellaneous

Plants over-expressing WHY2 are small with dark-green distorted leaves, exhibit early senescence and produces shorter siliques with half the amount of seeds found in wild-type plants.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentDNA repair complex
Cellular Componentmitochondrion
Molecular FunctionDNA binding
Molecular FunctionmRNA binding
Molecular Functionsingle-stranded DNA binding
Biological Processdefense response
Biological ProcessDNA repair
Biological Processregulation of DNA-templated transcription

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Single-stranded DNA-binding protein WHY2, mitochondrial
  • Alternative names
    • Protein WHIRLY 2 (AtWHY2)

Gene names

    • Name
      WHY2
    • ORF names
      F3I17.9
    • Ordered locus names
      At1g71260

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q8VYF7
  • Secondary accessions
    • Q9FVV2

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype under normal growth conditions.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 18 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for transit peptide, chain.

TypeIDPosition(s)Description
Transit peptide1-29Mitochondrion
ChainPRO_000042044830-238Single-stranded DNA-binding protein WHY2, mitochondrial

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homotetramer.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q8VYF7GWD1 Q9SAC63EBI-15219982, EBI-2355356

Complex viewer

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region62-67Required for ssDNA binding

Sequence similarities

Belongs to the Whirly family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    238
  • Mass (Da)
    26,295
  • Last updated
    2002-03-01 v1
  • Checksum
    F5586CABDABF4E02
MMKQARSLLSRSLCDQSKSLFEASTLRGFASWSNSSTPGRGFPGKDAAKPSGRLFAPYSIFKGKAALSVEPVLPSFTEIDSGNLRIDRRGSLMMTFMPAIGERKYDWEKKQKFALSPTEVGSLISMGSKDSSEFFHDPSMKSSNAGQVRKSLSVKPHADGSGYFISLSVNNSILKTNDYFVVPVTKAEFAVMKTAFSFALPHIMGWNRLTGHVNTEALPSRNVSHLKTEPQLELEWDK

Sequence caution

The sequence AAG51881.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC016162
EMBL· GenBank· DDBJ
AAG51881.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
CP002684
EMBL· GenBank· DDBJ
AEE35181.1
EMBL· GenBank· DDBJ
Genomic DNA
AY072110
EMBL· GenBank· DDBJ
AAL59932.1
EMBL· GenBank· DDBJ
mRNA
AY122961
EMBL· GenBank· DDBJ
AAM67494.1
EMBL· GenBank· DDBJ
mRNA
AB493532
EMBL· GenBank· DDBJ
BAH30370.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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