Q8VYB2 · UKL3_ARATH

Function

function

Involved in the pyrimidine salvage pathway. The uracil phosphoribosyltransferase (UPRT) activity, that catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate, is unsure.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.
Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.
Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site280GTP (UniProtKB | ChEBI)
Binding site289GTP (UniProtKB | ChEBI)
Binding site323-326GTP (UniProtKB | ChEBI)
Binding site3335-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site3585-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site378GTP (UniProtKB | ChEBI)
Binding site3845-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site389-3925-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site454-456uracil (UniProtKB | ChEBI)
Binding site4555-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functioncytidine kinase activity
Molecular FunctionGTP binding
Molecular Functionuracil phosphoribosyltransferase activity
Molecular Functionuridine kinase activity
Biological Processcellular response to hypoxia
Biological ProcessCTP salvage
Biological Processphosphorylation
Biological ProcessUMP salvage

Keywords

Enzyme and pathway databases

    • UPA00574UER00636
    • UPA00574UER00637
    • UPA00579UER00640

Names & Taxonomy

Protein names

  • Recommended name
    Uridine kinase-like protein 3

Including 2 domains:

  • Recommended name
    Putative uracil phosphoribosyltransferase
  • EC number
  • Short names
    UPRTase
  • Alternative names
    • UMP pyrophosphorylase

Gene names

    • Name
      UKL3
    • ORF names
      F20N2.21
    • Ordered locus names
      At1g55810

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q8VYB2
  • Secondary accessions
    • A8MQ84
    • Q9LG32

Proteomes

Organism-specific databases

Genome annotation databases

Phenotypes & Variants

Disruption phenotype

No visible phenotype. No decrease in uracil phosphoribosyltransferase activity.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 24 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003945161-466Uridine kinase-like protein 3

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region41-246Uridine kinase
Region256-466Uracil phosphoribosyltransferase

Sequence similarities

In the N-terminal section; belongs to the uridine kinase family.
In the C-terminal section; belongs to the UPRTase family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8VYB2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    466
  • Mass (Da)
    52,443
  • Last updated
    2002-03-01 v1
  • Checksum
    3FA6783CB49727F7
MASKSDVNIIETSSKVHFSGFHQMDGLASNRPEQMAEEEEHGQPFVIGVAGGAASGKTTVCDMIMQQLHDQRAVVVNQDSFYHNVNEVELVRVHDYNFDHPDAFDTEQLLSSMEKLRKGQAVDIPNYDFKSYKNNVFPPRRVNPSDVIILEGILIFHDPRVRDLMNMKIFVDADADVRLARRIKRDTVEKGRDIATVLDQYSKFVKPAFEDFILPTKKYADIIIPRGGDNHVAIDLIVQHIHTKLGQHDLCKIYPNLYVIQSTFQIRGMHTLIRDSKTTKHDFIFYSDRLIRLVVEHGLGHLPFTEKQVVTPTGSVYSGVDFCKKLCGVSVIRSGESMENALRACCKGIKIGKILIHREGDNGQQLIYEKLPSDISERHVLLLDPILGTGNSAVQAIRLLISKGVPESNIIFLNLISAPEGVNVVCKKFPRIKIVTSEIELGLNDEFRVVPGMGEFGDRYFGTDDE

Q8VYB2-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1P8AWM1A0A1P8AWM1_ARATHUKL3488
A0A1P8AWK0A0A1P8AWK0_ARATHUKL3451

Sequence caution

The sequence AAF79310.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_039280366-370in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC002304
EMBL· GenBank· DDBJ
AAF79310.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002684
EMBL· GenBank· DDBJ
AEE33300.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE33301.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE33302.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
ANM61033.1
EMBL· GenBank· DDBJ
Genomic DNA
AY072218
EMBL· GenBank· DDBJ
AAL60039.1
EMBL· GenBank· DDBJ
mRNA
AY122946
EMBL· GenBank· DDBJ
AAM67479.1
EMBL· GenBank· DDBJ
mRNA
AK317232
EMBL· GenBank· DDBJ
BAH19913.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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