Q8VHL1 · SETD7_MOUSE

  • Protein
    Histone-lysine N-methyltransferase SETD7
  • Gene
    Setd7
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (By similarity).
H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity).
Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:12711597).
Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (By similarity).
Has also methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed:35210392).
Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (By similarity).
Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (By similarity).
Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (PubMed:35210392).

Catalytic activity

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site226-228S-adenosyl-L-methionine (UniProtKB | ChEBI)
Site245Histone H3K4 binding
Site256Histone H3K4 binding
Site266Histone H3K4 binding
Binding site296S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site297S-adenosyl-L-methionine (UniProtKB | ChEBI)
Site317Histone H3K4 binding
Site335Histone H3K4 binding
Binding site356S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular Componentnucleolus
Cellular Componentnucleus
Molecular Functionchromatin binding
Molecular Functionhistone H3K4 monomethyltransferase activity
Molecular Functionhistone methyltransferase activity
Molecular Functionp53 binding
Molecular Functionprotein-lysine N-methyltransferase activity
Biological Processchromatin organization
Biological ProcessDNA damage response
Biological Processheterochromatin organization
Biological Processpeptidyl-lysine dimethylation
Biological Processpeptidyl-lysine monomethylation
Biological Processpositive regulation of DNA-templated transcription
Biological Processresponse to ethanol

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone-lysine N-methyltransferase SETD7
  • EC number
  • Alternative names
    • Histone H3-K4 methyltransferase SETD7 (H3-K4-HMTase SETD7)
    • SET domain-containing protein 7
    • SET7/9

Gene names

    • Name
      Setd7
    • Synonyms
      Kiaa1717, Set7, Set9
Community curation (1)

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • NOD
    • 129/Sv X 129SvCp
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8VHL1
  • Secondary accessions
    • Q6ZPJ6
    • Q80UU3
    • Q8C7Y6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis297Abolishes methyltransferase activity.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 16 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001860551-366Histone-lysine N-methyltransferase SETD7

Proteomic databases

PTM databases

Expression

Developmental stage

Expressed during all pre-implementation stages in both male and female embryos.

Gene expression databases

Interaction

Subunit

Interacts with IPF1/PDX-1.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for repeat, domain.

TypeIDPosition(s)Description
Repeat36-58MORN 1
Repeat59-81MORN 2
Repeat106-128MORN 3
Domain214-336SET

Domain

The SET domain is necessary but not sufficient for histone methyltransferase activity.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    366
  • Mass (Da)
    40,506
  • Last updated
    2008-02-05 v2
  • Checksum
    C826EAFCB4B9D345
MDSDDEVVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDSDGRLIFKGQYKDNNRHGVCWIHYPDGGSLVGEVNEDGEMTGEKIAYVYPDQRTALYGKFIDGEMLEGKLATLMATEEGRPHFEVTSGSSVYHFDKSTSSCISSDALLPDPYESERVYVADSLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCVYDLFVHPRFGPIKCIRTLRAVEAEEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK

Sequence caution

The sequence BAC98238.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict77in Ref. 4; AAH50190
Sequence conflict165in Ref. 1; AAL56578

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF448509
EMBL· GenBank· DDBJ
AAL56578.1
EMBL· GenBank· DDBJ
mRNA
AK129428
EMBL· GenBank· DDBJ
BAC98238.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK048924
EMBL· GenBank· DDBJ
BAC33493.1
EMBL· GenBank· DDBJ
mRNA
AK147422
EMBL· GenBank· DDBJ
BAE27903.1
EMBL· GenBank· DDBJ
mRNA
AK147413
EMBL· GenBank· DDBJ
BAE27897.1
EMBL· GenBank· DDBJ
mRNA
AK147667
EMBL· GenBank· DDBJ
BAE28059.1
EMBL· GenBank· DDBJ
mRNA
AK170161
EMBL· GenBank· DDBJ
BAE41607.1
EMBL· GenBank· DDBJ
mRNA
BC050190
EMBL· GenBank· DDBJ
AAH50190.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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